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The Link between Phylogeny and Virulence in Escherichia coli Extraintestinal Infection
Open accessAbstract
Previous studies suggesting a link between Escherichia coli phylogenetic groups and extraintestinal virulence have been hampered by the difficulty in establishing the intrinsic virulence of a bacterial strain. Indeed, unidentified virulence factors do exist, and the susceptibility of the host to infection is highly variable. To overcome these difficulties, we have developed a mouse model of extraintestinal virulence to test the virulence of the strains under normalized conditions. We then assessed the phylogenetic relationships compared to the E. coli reference (ECOR) collection, the presence of several known virulence determinants, and the lethality to mice of 82 human adult E. coli strains isolated from normal feces and during the course of extraintestinal infections. Commensal strains belong mainly to phylogenetic groups A and B1, are devoid of virulence determinants, and do not kill the mice. Strains exhibiting the same characteristics as the commensal strains can be isolated under pathogenic conditions, thus indicating the role of host-dependent factors, such as susceptibility linked to underlying disease, in the development of infection. Some strains of phylogenetic groups A, B1, and D are able to kill the mice, their virulence being most often correlated with the presence of virulence determinants. Lastly, strains of the B2 phylogenetic group represent a divergent lineage of highly virulent strains which kill the mice at high frequency and possess the highest level of virulence determinants. The observed link between virulence and phylogeny could correspond to the necessity of virulence determinants in a genetic background that is adequate for the emergence of a virulent clone, an expression of the interdependency of pathogenicity and metabolic activities in pathogenic bacteria.
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“strains responsible for extra-intestinal infection were far more likely to be members of phylogroups B2 than A [143, 144]”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [143]
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Citations
Cites
Escherichia coli and Salmonella :cellular and molecular biology
Neidhardt, F. C. (1996) · ASM Press eBooks · Cited by 8,197
Theory and Applications of Correspondence Analysis.
Jolliffe, I. T., & Greenacre, M. J. (1986) · Biometrics · doi:10.2307/2531266 · Cited by 3,026
Smith, J. M., Smith, N. H., O'Rourke, M., & Spratt, B. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4384 · Cited by 1,802
The indigenous gastrointestinal microflora
Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153 · cited 1×
“In humans, strains of the species Escherichia coli can be commensal (since they are part of the normal intestinal microbial flora) and/or the cause of various infectious diseases (intestinal and extraintestinal infections) (2, 10).”
BackgroundPathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution
Hacker, J. H., Blum–Oehler, G., Mühldorfer, I., & Tschäpe, H. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.3101672.x · Cited by 1,130
Standard reference strains of Escherichia coli from natural populations
Ochman, H., & Selander, R. K. (1984) · Journal of Bacteriology · doi:10.1128/jb.157.2.690-693.1984 · Cited by 811
Herzer, P., Inouye, S., Inouye, M., & Whittam, T. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.11.6175-6181.1990 · Cited by 564
Tenenhaus, M., & Young, F. W. (1985) · Psychometrika · doi:10.1007/bf02294151 · Cited by 419
Genetic Diversity and Structure in Escherichia coli Populations
Selander, R. K., & Levin, B. R. (1980) · Science · doi:10.1126/science.6999623 · Cited by 413
Whittam, T. S., Wolfe, M. L., Wachsmuth, I. K., Ørskov, F., Ørskov, I., & Wilson, R. A. (1993) · Infection and Immunity · doi:10.1128/iai.61.5.1619-1629.1993 · Cited by 370
Virulence and transmissibility of pathogens: what is the relationship?
Lipsitch, M., & Moxon, E. R. (1997) · Trends in Microbiology · doi:10.1016/s0966-842x(97)81772-6 · Cited by 344
Bouguénec, C. L., Archambaud, M., & Labigne-Roussel, A. (1992) · Journal of Clinical Microbiology · doi:10.1128/jcm.30.5.1189-1193.1992 · Cited by 339
Pupo, G. M., Karaolis, D. K. R., Lan, R., & Reeves, P. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.7.2685-2692.1997 · Cited by 302
Bingen, É., Picard, B., Brahimi, N., Mathy, S., Desjardins, P., Élion, J., & Denamur, É. (1998) · The Journal of Infectious Diseases · doi:10.1086/514217 · Cited by 255
Self-citationHuang, S. H., Wass, C. A., Fu, Q., Prasadarao, N. V., Stins, M. F., & Kim, K. (1995) · Infection and Immunity · doi:10.1128/iai.63.11.4470-4475.1995 · Cited by 222
Escherichia coli molecular phylogeny using the incongruence length difference test
Lecointre, G., Rachdi, L., Darlu, P., & Denamur, É. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025895 · Cited by 209
Boyd, E. F., & Hartl, D. L. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.5.1159-1165.1998 · Cited by 206
Selander, R. K., Korhonen, T. K., Väisänen-Rhen, V., WILLIAMS, P. H., Pattison, P. E., & Caugant, D. A. (1986) · Infection and Immunity · doi:10.1128/iai.52.1.213-222.1986 · Cited by 131
Desjardins, P., Picard, B., Kaltenboeck, B., Élion, J., & Denamurl, E. (1995) · Journal of Molecular Evolution · doi:10.1007/bf00160315 · Cited by 118
Self-citationBingen, É., Denamur, É., Lambert-zechovsky, N., Aujard, Y., Brahimi, N., Geslin, P., & Élion, J. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/165.3.569 · Cited by 107
Self-citationGenetic aspects of Escherichia coli virulence
Mühldorfer, I., & Hacker, J. H. (1994) · Microbial Pathogenesis · doi:10.1006/mpat.1994.1018 · Cited by 99
Johnson, J. R., Ørskov, I., Orskov, F., Goullet, P., Picard, B., Moseley, S. L., Roberts, P. L., & Stamm, W. E. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/169.1.119 · Cited by 92
Self-citationJohnson, J. R., Goullet, P., Picard, B., Moseley, S. L., Roberts, P. L., & Stamm, W. E. (1991) · Infection and Immunity · doi:10.1128/iai.59.7.2311-2315.1991 · Cited by 91
Self-citationRecombination and Population Structure in Escherichia coli
Milkman, R. (1997) · Genetics · doi:10.1093/genetics/146.3.745 · Cited by 88
Arthur, M., Arbeit, R. D., Kim, C., Beltran, P. J., Crowe, H. M., Steinbach, S., Campanelli, C., Wilson, R. A., Selander, R. K., & Goldstein, R. (1990) · Infection and Immunity · doi:10.1128/iai.58.2.471-479.1990 · Cited by 83
Clonal relationships among bloodstream isolates of Escherichia coli
Maslow, J. N., Whittam, T. S., Gilks, C. F., Wilson, R. A., Mulligan, M. E., Adams, K. S., & Arbeit, R. D. (1995) · Infection and Immunity · doi:10.1128/iai.63.7.2409-2417.1995 · Cited by 72
Bingen, É., Denamur, É., Lambert-zechovsky, N., Bourdois, A., Mariani‐Kurkdjian, P., Cézard, J., Navarro, J., & Élion, J. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.7.1348-1350.1991 · Cited by 63
Recombination and clonality in natural populations of Escherichia coli
Guttman, D. S. (1997) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(96)10057-4 · Cited by 63
Clonal relationships among Escherichia coli serogroup O78 isolates from human and animal infections
Cherifi, A., Contrepois, M., Picard, B., Goullet, P., Ørskov, I., & Ørskov, F. (1994) · Journal of Clinical Microbiology · doi:10.1128/jcm.32.5.1197-1202.1994 · Cited by 54
Self-citationMaslow, J. N., Mulligan, M. E., Adams, K. S., Justis, J. C., & Arbeit, R. D. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/17.1.89 · Cited by 51
Regulatory genes in the thermoregulation of Escherichia coli pili gene transcription.Preprint
Göransson, M., Forsman, K., & Uhlin, B. E. (1989) · Genes & Development · doi:10.1101/gad.3.1.123 · Cited by 50
Goullet, P., & Picard, B. (1986) · Microbiology · doi:10.1099/00221287-132-7-1843 · Cited by 47
Self-citationGoullet, P., & Picard, B. (1986) · Microbiology · doi:10.1099/00221287-132-7-1853 · Cited by 40
Self-citationClonal relationships among Escherichia coli serogroup 06 isolates from human and animal infections
Cherifi, A., Contrepois, M., Picard, B., Goullet, P., Ørskov, I., Ørskov, F., & de Rycke, J. (1991) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1991.tb04666.x · Cited by 34
Self-citationPicard, B., Picard-Pasquier, N., Krishnamoorthy, R., & Goullet, P. (1991) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1991.tb04862.x · Cited by 33
Self-citationPicard, B., & Goullet, P. (1988) · Epidemiology and Infection · doi:10.1017/s0950268800065559 · Cited by 28
Self-citationPicard, B., Journet-Mancy, C., Picard-Pasquier, N., & Goullet, P. (1993) · Journal of General Microbiology · doi:10.1099/00221287-139-12-3079 · Cited by 27
Self-citationTullus, K., Brauner, A., Fryklund, B. A., Munkhammar, T., Rabsch, W., Reissbrodt, R., & BURMAN, L. G. (1992) · Journal of Medical Microbiology · doi:10.1099/00222615-36-3-203 · Cited by 24
Identification of Escherichia coli K1 antigen
Cross, A. S., Ørskov, I., Ørskov, F., SADOFF, J. C., & Gemski, P. (1984) · Journal of Clinical Microbiology · doi:10.1128/jcm.20.2.302-304.1984 · Cited by 21
Picard, B., Goullet, P., & Krishnamoorthy, R. (1987) · Biochemical Journal · doi:10.1042/bj2410877 · Cited by 17
Self-citationAnalysis of the variability of S-fimbriae expression in anEscherichia colipathogen
Ott, M., & Hacker, J. (1991) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1991.tb04534.x · Cited by 12
Rashbass, J. (1997) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(97)80008-0 · Cited by 5
Research works printed but not linked: 1
- Lebart L. Morineau A. Warwick K. M. Multivariate descriptive analysis: correspondence analysis and related technique for large matrices. 1984 Wiley-Interscience New York N.Y
Cited by
Sorted by citations
Rapid and Simple Determination of the Escherichia coli Phylogenetic Group
Clermont, O., Bonacorsi, S., & Bingen, É. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.10.4555-4558.2000 · Cited by 2,647
Clermont, O., Christenson, J. K., Denamur, E., & Gordon, D. M. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12019 · Cited by 1,698
Johnson, J. R., & Stell, A. L. (2000) · The Journal of Infectious Diseases · doi:10.1086/315217 · Cited by 1,269
Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells
Nougayrède, J.-P., Homburg, S., Taieb, F., Boury, M., Brzuszkiewicz, E., Gottschalk, G., Buchrieser, C., Hacker, J., Dobrindt, U., & Oswald, E. (2006) · Science · doi:10.1126/science.1127059 · Cited by 1,188
Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
Touchon, M., Hoede, C., Tenaillon, O., Barbe, V., Baeriswyl, S., Bidet, P., Bingen, É., Bonacorsi, S., Bouchier, C., Bouvet, O. M. M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000344 · Cited by 1,248
Metadata
- Authors
- Picard, B., Garcia, J. S., Gouriou, S., Duriez, P., Brahimi, N., Bingen, E., Elion, J., & Denamur, E.
- Affiliations
- Centre Hospitalier Régional Universitaire de Brest (FR)
- <!--label omitted: 2-->Laboratoire de Microbiologie, Hôpital Cochin, Assistance Publique—Hôpitaux de Paris,2
- Inserm (FR)
- <!--label omitted: 4-->Laboratoire de Recherche en Bactériologie Pédiatrique (JE 2255), Université Denis Diderot-Paris 7,4 Hôpital Robert Debré, Paris, France
- <!--label omitted: 3-->INSERM U 4583 and
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1999-02
- Volume
- 67
- Issue
- 2
- Pages
- 546-553
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC96353
- OpenAlex
- W2125201618
- Cited by
- 794
- References
- 42
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 32 · 2023: 27 · 2022: 43 · 2021: 39 · 2020: 46 · 2019: 33 · 2018: 29 · 2017: 34 · 2016: 39 · 2015: 46 · 2014: 52 · 2013: 38 · 2012: 36
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Immunology and Microbiology › Microbiology › Enterobacteriaceae and Cronobacter Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Escherichia coli, phylogenetic groups, extraintestinal infections, bacterial virulence, virulence factors, commensal strains, host susceptibility, pathogenicity, virulent clones
- MeSH terms
- Adult, Animals, Disease Models, Animal, Escherichia coli, Escherichia coli Infections, Female, Humans, Phylogeny, Virulence, Mice
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