The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Specificity of the Protective Antibody Response to Apical Membrane Antigen 1
Open accessAbstract
Apical membrane antigen 1 (AMA1) is considered one of the leading candidates for inclusion in a vaccine against blood stages of Plasmodium falciparum . Although the ama1 gene is relatively conserved compared to those for some other potential vaccine components, numerous point mutations have resulted in amino acid substitutions at many sites in the polypeptide. The polymorphisms in AMA1 have been attributed to the diversifying selection pressure of the protective immune responses. It was therefore of interest to investigate the impact of sequence diversity in P. falciparum AMA1 on the ability of anti-AMA1 antibodies to inhibit the invasion of erythrocytes in vitro by P. falciparum merozoites. For these studies, we used antibodies to recombinant P. falciparum 3D7 AMA1 ectodomain, which was prepared for testing in early clinical trials. Antibodies were raised in rabbits to the antigen formulated in Montanide ISA720, and human antibodies to AMA1 were isolated by affinity purification from the plasma of adults living in regions of Papua New Guinea where malaria is endemic. Both rabbit and human anti-AMA1 antibodies were found to be strongly inhibitory to the invasion of erythrocytes by merozoites from both the homologous and two heterologous lines of P. falciparum . The inhibitory antibodies targeted both conserved and strain-specific epitopes within the ectodomain of AMA1; however, it appears that the majority of these antibodies reacted with strain-specific epitopes in domain I, the N-terminal disulfide-bonded domain, which is the most polymorphic region of AMA1.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,385
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Human Malaria Parasites in Continuous Culture
Trager, W., & Jensen, J. B. (1976) · Science · doi:10.1126/science.781840 · Cited by 7,844
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
Laemmli, U. K. (1970) · Nature · Cited by 5,673
Synchronization of Plasmodium falciparum Erythrocytic Stages in Culture
Lambros, C., & Vanderberg, J. P. (1979) · The Journal of Parasitology · doi:10.2307/3280287 · Cited by 3,677
Gamma-Globulin and Acquired Immunity to Human Malaria
COHEN, S., McGREGOR, I. A., & CARRINGTON, S. (1961) · Nature · doi:10.1038/192733a0 · Cited by 1,393
Parasitologic and Clinical Human Response to Immunoglobulin Administration in Falciparum Malaria
Sabchareon, A., Burnouf, T., Ouattara, D., Attanath, P., Bouharoun-Tayoun, H., Chantavanich, P., Foucault, C., Chongsuphajaisiddhi, T., & Druilhe, P. (1991) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1991.45.297 · Cited by 499
Oeuvray, C., Bouharoun-Tayoun, H., Gras-Masse, H., Bottius, E., Kaidoh, T., Aikawa, M., Filgueira, M., Tartar, A., & Druilhe, P. (1994) · Blood · doi:10.1182/blood.v84.5.1594.1594 · Cited by 268
Narum, D. L., & Thomas, A. W. (1994) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(94)90096-5 · Cited by 268
Cited by
Doolan, D. L., Dobaño, C., & Baird, J. K. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00025-08 · Cited by 1,301
Fowkes, F. J. I., Richards, J. S., Simpson, J. A., & Beeson, J. G. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000218 · Cited by 345
Maier, A. G., Duraisingh, M. T., Reeder, J. C., Patel, S. S., Kazura, J. W., Zimmerman, P. A., & Cowman, A. F. (2003) · Nature Medicine · doi:10.1038/nm807 · Cited by 345
Silvie, O., Franetich, J.-F., Charrin, S., Mueller, M. S., Siau, A., Bodescot, M., Rubinstein, E., Hannoun, L., Charoenvit, Y., Kocken, C. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311331200 · Cited by 340
Self-citationBoyle, M. J., Reiling, L., Feng, G., Langer, C., Osier, F. H., Aspeling-Jones, H., Cheng, Y. S., Stubbs, J., Tetteh, K. K. A., Conway, D. J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.012 · Cited by 306
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Metadata
- Authors
- Hodder, A. N., Crewther, P. E., & Anders, R. F.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2001-05
- Volume
- 69
- Issue
- 5
- Pages
- 3286-3294
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2069460651
- Cited by
- 324
- References
- 24
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- green
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