The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
ideR , an Essential Gene in Mycobacterium tuberculosis : Role of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress Response
Open accessAbstract
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence that ideR is an essential gene in Mycobacterium tuberculosis. ideR cannot normally be disrupted in this mycobacterium in the absence of a second functional copy of the gene. However, a rare ideR mutant was obtained in which the lethal effects of ideR inactivation were alleviated by a second-site suppressor mutation and which exhibited restricted iron assimilation capacity. Studies of this strain and a derivative in which IdeR expression was restored allowed us to identify phenotypic effects resulting from ideR inactivation. Using DNA microarrays, the iron-dependent transcriptional profiles of the wild-type, ideR mutant, and ideR -complemented mutant strains were analyzed, and the genes regulated by iron and IdeR were identified. These genes encode a variety of proteins, including putative transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, a membrane protein involved in virulence, transcriptional regulators, and enzymes involved in lipid metabolism.
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Cites
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[25] Genetic systems for mycobacteria
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Cited by
Genes required for mycobacterial growth defined by high density mutagenesis
Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages
Schnappinger, D., Ehrt, S., Voskuil, M. I., Liu, Y., Mangan, J. A., Monahan, I. M., Dolganov, G., Efron, B., Butcher, P. D., Nathan, C., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030846 · Cited by 1,420
Self-citationMycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
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Park, H., Guinn, K. M., Harrell, M. I., Liao, R., Voskuil, M. I., Tompa, M., Schoolnik, G. K., & Sherman, D. R. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03474.x · Cited by 712
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Metadata
- Authors
- Rodriguez, G. M., Voskuil, M. I., Gold, B., Schoolnik, G. K., & Smith, I.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2002-07
- Volume
- 70
- Issue
- 7
- Pages
- 3371-3381
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2140286346
- Cited by
- 490
- References
- 43
- FWCI
- 14.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Rodriguez, G. M., Voskuil, M. I., Gold, B., Schoolnik, G. K., & Smith, I. (2002). ideR , an Essential Gene in Mycobacterium tuberculosis : Role of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress Response. Infection and Immunity. https://doi.org/10.1128/iai.70.7.3371-3381.2002
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