Cited by 153Pneumonia and Respiratory InfectionsBacterial Infections and VaccinesMicrobial infections and disease research

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization

Open access

McCool, Tera L., Weiser, Jeffrey N.·2004·Infection and Immunity

DOI 10.1128/iai.72.10.5807-5813.2004PMC PMC517579

Open this paper in CoChat — free account

Abstract

Colonization is the first step in the interaction between Streptococcus pneumoniae and its human host. To better understand the mechanisms contributing to natural carriage, a mouse model of pneumococcal colonization was developed with a clinical isolate of S. pneumoniae previously characterized in experimental colonization of humans. Similar to carriage events in humans, colonization of mice was self-limited and there was no evidence of lower respiratory tract or invasive disease. Carriage induced a serum antibody response to whole pneumococci that was associated temporally with clearance of colonization in three inbred strains of mice. Individual mice, however, did not demonstrate a correlation between the density of colonization and amounts of serum or of mucosal antibodies, including antibodies of different isotypes and antigenic specificities. The role of antibody in the clearance of carriage was then examined in mice with genetic defects in humoral immunity. xid mice, which have deficient responses to polysaccharide antigens, cleared colonization at the same rate as the parent strain. Finally, we showed that μMT mice, which lack mature B cells and fail to produce antibody, were unaffected in the density or duration of colonization. These results demonstrate that antibody is not required for clearance of pneumococcal colonization in mice.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/iai.72.10.5807-5813.2004

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Streptococcus pneumoniae colonisation: the key to pneumococcal disease
Bogaert, D., de Groot, R., & Hermans, P. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)00938-7 · Cited by 1,929 · cited 2×
“All pneumococcal infection, however, begins with colonization of the mucosal surface of the nasopharynx, a state far more common than host-pathogen interactions leading to disease (2, 5, 32).”
Background
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
Blunt, T., Finnie, N., Taccioli, G. E., Smith, G. C. M., Demengeot, J., Gottlieb, T. M., Mizuta, R., Varghese, A. J., Alt, F. W., Jeggo, P. A., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90360-7 · Cited by 865
Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice
Rawlings, D. J., Saffran, D. C., Tsukada, S., Largaespada, D. A., Grimaldi, J. C., Cohen, L., Mohr, R. N., Bazán, J. F., Howard, M., Copeland, N. G., et al. (1993) · Science · doi:10.1126/science.8332901 · Cited by 859
Epidemiologic Studies of Streptococcus pneumoniae in Infants: Acquisition, Carriage, and Infection during the First 24 Months of Life
Gray, B. M., Converse, G. M., & Dillon, H. C. (1980) · The Journal of Infectious Diseases · doi:10.1093/infdis/142.6.923 · Cited by 797
Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes
Thomas, J. D., Sideras, P., Smith, C. I. E., Vořechovský, I., Chapman, V. M., & Paul, W. E. (1993) · Science · doi:10.1126/science.8332900 · Cited by 613
PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES
MacLeod, C. M., Hodges, R. G., Heidelberger, M., & Bernhard, W. G. (1945) · The Journal of Experimental Medicine · doi:10.1084/jem.82.6.445 · Cited by 518
Immunogenicity and Impact on Nasopharyngeal Carriage of a Nonavalent Pneumococcal Conjugate Vaccine
Mbelle, N. M., Huebner, R. E., Wasas, A. D., KIMURA, A. E., Chang, I., & Klugman, K. P. (1999) · The Journal of Infectious Diseases · doi:10.1086/315009 · Cited by 515
Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization
Weiser, J. N., AUSTRIAN, R. C., Sreenivasan, P. K., & Masure, H. R. (1994) · Infection and Immunity · doi:10.1128/iai.62.6.2582-2589.1994 · Cited by 423
Self-citation
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE
Amsbaugh, D. F., Hansen, C. T., Prescott, B., Stashak, P. W., Barthold, D. R., & Baker, P. J. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.136.4.931 · Cited by 345

Show all 37 references

Sorted by citations

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
Kadioglu, A., Weiser, J. N., Paton, J. C., & Andrew, P. W. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1871 · Cited by 1,184
Self-citation
The fundamental link between pneumococcal carriage and disease
Simell, B., Auranen, K. J., Käyhty, H. M., Goldblatt, D., Dagan, R., O’Brien, K. L., & for the Pneumococcal Carriage Group (PneumoCarr) (2012) · Expert Review of Vaccines · doi:10.1586/erv.12.53 · Cited by 633
Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization
Lu, Y., Gross, J. A., Bogaert, D., Finn, A. H. R., Bagrade, L., Zhang, Q., Kolls, J. K., Srivastava, A., Lundgren, A., Forte, S., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000159 · Cited by 500
Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice
Zhang, Z., Clarke, T. B., & Weiser, J. N. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36731 · Cited by 466
Self-citation
The microbiota protects against respiratory infection via GM-CSF signaling
Brown, R. L., Sequeira, R. P., & Clarke, T. B. (2017) · Nature Communications · doi:10.1038/s41467-017-01803-x · Cited by 378
CD4 + T cells mediate antibody-independent acquired immunity to pneumococcal colonization
Malley, R., Trzcinski, K., Srivastava, A., Thompson, C. M., Anderson, P. W., & Lipsitch, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501254102 · Cited by 346
Capsule Enhances Pneumococcal Colonization by Limiting Mucus-Mediated Clearance
Nelson, A. L., Roche, A. M., Gould, J. M., Chim, K., Ratner, A. J., & Weiser, J. N. (2006) · Infection and Immunity · doi:10.1128/iai.01475-06 · Cited by 359
Self-citation
Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice
Nakamura, S., Davis, K. M., & Weiser, J. N. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57762 · Cited by 280
Self-citation
Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae
King, S. J., Hippe, K. R., & Weiser, J. N. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04984.x · Cited by 233
Self-citation
The Role of Innate Immune Responses in the Outcome of Interspecies Competition for Colonization of Mucosal Surfaces
Lysenko, E. S., Ratner, A. J., Nelson, A. L., & Weiser, J. N. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010001 · Cited by 218
Self-citation
Host and Bacterial Factors Contributing to the Clearance of Colonization by Streptococcus pneumoniae in a Murine Model
van Rossum, A. M. C., Lysenko, E. S., & Weiser, J. N. (2005) · Infection and Immunity · doi:10.1128/iai.73.11.7718-7726.2005 · Cited by 206
Self-citation
Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice
Davis, K. M., Nakamura, S., & Weiser, J. N. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57761 · Cited by 190
Self-citation
The blp Bacteriocins of Streptococcus pneumoniae Mediate Intraspecies Competition both In Vitro and In Vivo
Dawid, S. R., Roche, A. M., & Weiser, J. N. (2006) · Infection and Immunity · doi:10.1128/iai.01775-05 · Cited by 188
Self-citation
Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin
Bachman, M. A., Miller, V. L., & Weiser, J. N. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000622 · Cited by 186
Self-citation
The pneumococcus: why a commensal misbehaves
Weiser, J. N. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0557-x · Cited by 184
Self-citation
Antibody-Independent, Interleukin-17A-Mediated, Cross-Serotype Immunity to Pneumococci in Mice Immunized Intranasally with the Cell Wall Polysaccharide
Malley, R., Srivastava, A. K., Lipsitch, M., Thompson, C. M., Watkins, A. C., Tzianabos, A. O., & Anderson, P. W. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2187-2195.2006 · Cited by 177
Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions.
Krone, C. L., van de Groep, K., Trzciński, K., Sanders, E. A. M., & Bogaert, D. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70165-6 · Cited by 134
Use of a Rapid Test of Pneumococcal Colonization Density to Diagnose Pneumococcal Pneumonia
Albrich, W. C., Madhi, S. A., Adrian, P. V., van Niekerk, N., Mareletsi, T., Cutland, C., Wong, M., KHOOSAL, M., Karstaedt, A., Zhao, P., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir859 · Cited by 134
Are Anticapsular Antibodies the Primary Mechanism of Protection against Invasive Pneumococcal Disease?
Lipsitch, M., Whitney, C. G., Zell, E. R., Kaijalainen, T., Dagan, R., & Malley, R. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020015 · Cited by 133
The Prevalence and Risk Factors for Pneumococcal Colonization of the Nasopharynx among Children in Kilifi District, Kenya
Abdullahi, O. A., Karani, A., Tigoi, C., Mugo, D., Kungu, S., Wanjiru, E., Jomo, J., Musyimi, R., Lipsitch, M., & Scott, J. A. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030787 · Cited by 118
Immunization withStaphylococcus aureusiron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model
Joshi, A., Pancari, G., Cope, L. D., Bowman, E. P., Cua, D., Proctor, R. A., & McNeely, T. B. (2012) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.18946 · Cited by 111
Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice
Ferreira, D. M., Darrieux, M., Andrade-Silva, D., Leite, L. C. C., Ferreira, J. M. C., Ho, P. L., Miyaji, E. N., & Oliveira, M. L. S. (2009) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00395-08 · Cited by 112
Th17 cell based vaccines in mucosal immunity
Kumar, P., Chen, K., & Kolls, J. K. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.03.011 · Cited by 105
Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen A
Oliveira, M. L. S., Arêas, A. P. M., de Campos, I. B., Monedero, V., Pérez‐Martínez, G., Miyaji, E. N., Leite, L. C. C., Aires, K. A., & Ho, P. L. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2005.10.020 · Cited by 107
Pneumococcal Surface Protein A Inhibits Complement Deposition on the Pneumococcal Surface by Competing with the Binding of C-Reactive Protein to Cell-Surface Phosphocholine
Mukerji, R., Mirza, S., Roche, A. M., Widener, R. W., Croney, C. M., Rhee, D., Weiser, J. N., Szalai, A. J., & Briles, D. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201967 · Cited by 106
Self-citation
Mechanisms of Naturally Acquired Immunity to Streptococcus pneumoniae
Ramos‐Sevillano, E., Ercoli, G., & Brown, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00358 · Cited by 109
Virulence in Mice of Pneumococcal Clonal Types with Known Invasive Disease Potential in Humans
Sandgren, A., Albiger, B., Orihuela, C. J., TUOMANEN, E. I., Normark, S. J., & Henriques‐Normark, B. (2005) · The Journal of Infectious Diseases · doi:10.1086/432513 · Cited by 103
Live Attenuated Streptococcus pneumoniae Strains Induce Serotype-Independent Mucosal and Systemic Protection in Mice
Roche, A. M., King, S. J., & Weiser, J. N. (2007) · Infection and Immunity · doi:10.1128/iai.01972-06 · Cited by 103
Self-citation
Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development
Malley, R. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0579-4 · Cited by 103
Booster Vaccinations: Can Immunologic Memory Outpace Disease Pathogenesis?
Pichichero, M. E. (2009) · PEDIATRICS · doi:10.1542/peds.2008-3645 · Cited by 101
Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage
Mitsi, E., Roche, A. M., Reiné, J., Zangari, T., Owugha, J., Pennington, S. H., Gritzfeld, J. F., Wright, A., Collins, A. M., van Selm, S., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.71 · Cited by 94
Self-citation
The immunological mechanisms that control pneumococcal carriage
Jochems, S. P., Weiser, J. N., Malley, R., & Ferreira, D. M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006665 · Cited by 98
Self-citation
Streptococcus pneumoniae Can Utilize Multiple Sources of Hyaluronic Acid for Growth
Marion, C., Stewart, J. M., Tazi, M., Burnaugh, A. M., Linke, C. M., Woodiga, S. A., & King, S. J. (2012) · Infection and Immunity · doi:10.1128/iai.05756-11 · Cited by 98
Low CD4 T Cell Immunity to Pneumolysin Is Associated with Nasopharyngeal Carriage of Pneumococci in Children
Zhang, Q., Bagrade, L., Bernatoniene, J., Clarke, E., Paton, J. C., Mitchell, T. J., Nunez, D. A., & Finn, A. H. R. (2007) · The Journal of Infectious Diseases · doi:10.1086/512617 · Cited by 95
Serotype-independent pneumococcal vaccines
Miyaji, E. N., Oliveira, M. L. S., Carvalho, E., & Ho, P. L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1234-8 · Cited by 96
Protection against Nasopharyngeal Colonization byStreptococcus pneumoniaeIs Mediated by Antigen-Specific CD4+T Cells
Trzciński, K., Thompson, C. M., Srivastava, A. K., Basset, A., Malley, R., & Lipsitch, M. (2008) · Infection and Immunity · doi:10.1128/iai.00141-08 · Cited by 90
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease
Richards, L., Ferreira, D. M., Miyaji, E. N., Andrew, P. W., & Kadioglu, A. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.12.004 · Cited by 91
Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity
Malley, R., & Anderson, P. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121383109 · Cited by 86
MARCO Is Required for TLR2- and Nod2-Mediated Responses to Streptococcus pneumoniae and Clearance of Pneumococcal Colonization in the Murine Nasopharynx
Dorrington, M. G., Roche, A. M., Chauvin, S., Tu, Z., Mossman, K. L., Weiser, J. N., & Bowdish, D. M. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202113 · Cited by 89
Self-citation
Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron-sequestering component of innate immunity
Nelson, A. L. A., Barasch, J. M., Bunte, R. M., & Weiser, J. N. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00566.x · Cited by 83
Self-citation
c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection
Ogunniyi, A. D., Paton, J. C., Kirby, A. C., McCullers, J. A., Cook, J., Hyodo, M., Hayakawa, Y., & Karaolis, D. K. R. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.06.099 · Cited by 80
Impaired Innate and Adaptive Immunity to Streptococcus pneumoniae and Its Effect on Colonization in an Infant Mouse Model
Bogaert, D., Weinberger, D. M., Thompson, C. M., Lipsitch, M., & Malley, R. (2009) · Infection and Immunity · doi:10.1128/iai.00871-08 · Cited by 77
Cross-protective mucosal immunity mediated by memory Th17 cells against Streptococcus pneumoniae lung infection
Wang, Y., Jiang, B., Guo, Y., Li, W., Tian, Y., Sonnenberg, G. F., Weiser, J. N., Ni, X., & Shen, H. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.41 · Cited by 71
Self-citation
Neutrophil-Toxin Interactions Promote Antigen Delivery and Mucosal Clearance of Streptococcus pneumoniae
Matthias, K., Roche, A. M., Standish, A. J., Shchepetov, M., & Weiser, J. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6246 · Cited by 72
Self-citation
Identification of an ATPase, MsmK, Which Energizes Multiple Carbohydrate ABC Transporters in Streptococcus pneumoniae
Marion, C., Aten, A. E., Woodiga, S. A., & King, S. J. (2011) · Infection and Immunity · doi:10.1128/iai.05290-11 · Cited by 72
Characterisation of Regulatory T Cells in Nasal Associated Lymphoid Tissue in Children: Relationships with Pneumococcal Colonization
Zhang, Q., Leong, S. C., McNamara, P. S., Mubarak, A., Malley, R., & Finn, A. H. R. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002175 · Cited by 70
Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model
Trzciński, K., Thompson, C. M., Malley, R., & Lipsitch, M. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.7043-7046.2005 · Cited by 71
Nasopharyngeal Colonization and Invasive Disease Are Enhanced by the Cell Wall Hydrolases LytB and LytC of Streptococcus pneumoniae
Ramos‐Sevillano, E., Moscoso, M., Garcı́a, P., Garcı́a, E., & Yuste, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023626 · Cited by 68
Sialic Acid Transport Contributes to Pneumococcal Colonization
Marion, C., Burnaugh, A. M., Woodiga, S. A., & King, S. J. (2010) · Infection and Immunity · doi:10.1128/iai.00832-10 · Cited by 72
Reduced Memory CD4+ T-Cell Generation in the Circulation of Young Children May Contribute to the Otitis-Prone Condition
Sharma, S., Casey, J. R., & Pichichero, M. E. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir340 · Cited by 67
Pathogen Diversity and Hidden Regimes of Apparent Competition
Cobey, S. E., & Lipsitch, M. (2012) · The American Naturalist · doi:10.1086/668598 · Cited by 64
Human Monocytes Promote Th1 and Th17 Responses to Streptococcus pneumoniae
Olliver, M., Hiew, J., Mellroth, P., Henriques‐Normark, B., & Bergman, P. (2011) · Infection and Immunity · doi:10.1128/iai.05286-11 · Cited by 64
Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage
Pennington, S. H., Pojar, S., Mitsi, E., Gritzfeld, J. F., Nikolaou, E., Solórzano, C., Owugha, J., Masood, Q., Gordon, M. A., Wright, A. D., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2467oc · Cited by 59
Rationale and prospects for novel pneumococcal vaccines
Moffitt, K. L., & Malley, R. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1087625 · Cited by 59
Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization
Jochems, S. P., de Ruiter, K., Solórzano, C., Voskamp, A. L., Mitsi, E., Nikolaou, E., Carniel, B. F., Pojar, S., German, E. L., Reiné, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128865 · Cited by 57
Serum antibody responses to pneumococcal colonization in the first 2 years of life: results from an SE Asian longitudinal cohort study
Turner, P., Turner, C. L., Green, N., Ashton, L., Lwe, E., Jankhot, A., Day, N., White, N. J., Nosten, F. H., & Goldblatt, D. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12286 · Cited by 56
Immunization of hamsters againstClostridium difficileinfection using the Cwp84 protease as an antigen
Péchiné, S., Denève-Larrazet, C., Monnier, A. L., Hoÿs, S., Janoir, C., & Collignon, A. (2011) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2011.00832.x · Cited by 56
Effect of Age and Vaccination With a Pneumococcal Conjugate Vaccine on the Density of Pneumococcal Nasopharyngeal Carriage
Roca, A., Bottomley, C., Hill, P. C., Bojang, A., Egere, U., Antonio, M., Darboe, O., Greenwood, B. M., & Adegbola, R. A. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis554 · Cited by 52
Sensing of Interleukin-1 Cytokines during Streptococcus pneumoniae Colonization Contributes to Macrophage Recruitment and Bacterial Clearance
Lemon, J. K., Miller, M. R., & Weiser, J. N. (2015) · Infection and Immunity · doi:10.1128/iai.00224-15 · Cited by 51
Self-citation
Epidemiological Evidence for Serotype‐Independent Acquired Immunity to Pneumococcal Carriage
Granat, S., Ollgren, J. P., Herva, E., Mia, Z., Auranen, K. J., & Mäkelä, P. H. (2009) · The Journal of Infectious Diseases · doi:10.1086/599364 · Cited by 52
Identification of a Pneumococcal Glycosidase That Modifies O-Linked Glycans
Marion, C., Limoli, D. H., Bobulsky, G. S., Abraham, J. L., Burnaugh, A. M., & King, S. J. (2009) · Infection and Immunity · doi:10.1128/iai.01215-08 · Cited by 51
Neonatal Fc Receptor–Targeted Therapies in Neurology
Nelke, C., Spatola, M., Schroeter, C. B., Wiendl, H., & Lünemann, J. D. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01175-7 · Cited by 48
Streptococcus pneumoniae nasopharyngeal colonization induces type I interferons and interferon-induced gene expression
Joyce, E. A., Popper, S. J., & Falkow, S. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-404 · Cited by 51
Experimental human pneumococcal carriage models for vaccine research
Ferreira, D. M., Jambo, K., & Gordon, S. B. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.06.003 · Cited by 49
Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine
Moffitt, K. L., Yadav, P., Weinberger, D. M., Anderson, P. W., & Malley, R. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.034 · Cited by 47
Protection against nasal colonization with Streptococcus pneumoniae by parenteral immunization with a DNA vaccine encoding PspA (Pneumococcal surface protein A)
Ferreira, D. M., Oliveira, M. L. S., Moreno, A. T., Ho, P. L., Briles, D. E., & Miyaji, E. N. (2010) · Microbial Pathogenesis · doi:10.1016/j.micpath.2010.02.009 · Cited by 46
BgaA acts as an adhesin to mediate attachment of some pneumococcal strains to human epithelial cells
Limoli, D. H., Sladek, J. A., Fuller, L. A., Singh, A. K., & King, S. J. (2011) · Microbiology · doi:10.1099/mic.0.045609-0 · Cited by 46
Early Bacterial Colonization Induces Toll-Like Receptor-Dependent Transforming Growth Factor β Signaling in the Epithelium
Beißwenger, C., Lysenko, E. S., & Weiser, J. N. (2009) · Infection and Immunity · doi:10.1128/iai.01224-08 · Cited by 45
Self-citation
Cigarette smoke-promoted acquisition of bacterial pathogens in the upper respiratory tract leads to enhanced inflammation in mice
Voss, M., Wonnenberg, B., Honecker, A., Kamyschnikow, A., Herr, C., Bischoff, M., Tschernig, T., Bals, R., & Beißwenger, C. (2015) · Respiratory Research · doi:10.1186/s12931-015-0204-8 · Cited by 44
Intranasal Immunization with the Cholera Toxin B Subunit-Pneumococcal Surface Antigen A Fusion Protein Induces Protection against Colonization with Streptococcus pneumoniae and Has Negligible Impact on the Nasopharyngeal and Oral Microbiota of Mice
Pimenta, F. C., Miyaji, E. N., Arêas, A. P. M., Oliveira, M. L. S., de Andrade, A. L. S. S., Ho, P. L., Hollingshead, S. K., & Leite, L. C. C. (2006) · Infection and Immunity · doi:10.1128/iai.00134-06 · Cited by 44
The Natural Cytotoxicity Receptor 1 Contribution to Early Clearance of Streptococcus pneumoniae and to Natural Killer-Macrophage Cross Talk
Elhaik-Goldman, S., Kafka, D., Yossef, R., Hadad, U., Elkabets, M., Vallon-Eberhard, A., Hulihel, L., Jung, S., Ghadially, H., Braiman, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023472 · Cited by 43
Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses
Babb, R., Chen, A., Hirst, T. R., Kara, E. E., McColl, S. R., Ogunniyi, A. D., Paton, J. C., & Alsharifi, M. (2016) · Clinical Science · doi:10.1042/cs20150699 · Cited by 45
Potential role for mucosally active vaccines against pneumococcal pneumonia
Jambo, K., Sepako, E., Heyderman, R. S., & Gordon, S. B. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2009.12.001 · Cited by 41
Regulation of Production of Mucosal Antibody to Pneumococcal Protein Antigens by T-Cell-Derived Gamma Interferon and Interleukin-10 in Children
Zhang, Q., Bernatoniene, J., Bagrade, L., Paton, J. C., Mitchell, T. J., Hammerschmidt, S., Nunez, D. A., & Finn, A. H. R. (2006) · Infection and Immunity · doi:10.1128/iai.00165-06 · Cited by 41
Immunization with Recombinant Streptococcus pneumoniae Neuraminidase NanA Protects Chinchillas against Nasopharyngeal Colonization
Tong, H. H., Li, D., Chen, S., Long, J. P., & DeMaria, T. F. (2005) · Infection and Immunity · doi:10.1128/iai.73.11.7775-7778.2005 · Cited by 40
Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking
Siegel, S. J., Tamashiro, E., & Weiser, J. N. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005004 · Cited by 38
Self-citation
Macrophage Migration Inhibitory Factor Promotes Clearance of Pneumococcal Colonization
Das, R., LaRose, M. I., Hergott, C. B., Leng, L., Bucala, R., & Weiser, J. N. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400133 · Cited by 36
Self-citation
Intranasal vaccination of neonatal mice with polysaccharide conjugate vaccine for protection against pneumococcal otitis media
Sabirov, A., & Metzger, D. W. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.04.033 · Cited by 36
Mucosal Immunization with Polyamine Transport Protein D (PotD) Protects Mice Against Nasopharyngeal Colonization with Streptococcus pneumoniae
Shah, P., Briles, D. E., King, J. D., Hale, Y., & Swiatlo, E. (2009) · Experimental Biology and Medicine · doi:10.3181/0809-rm-269 · Cited by 35
Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection
Hergott, C. A., Roche, A. M., Naidu, N. A., Mesaros, C., Blair, I. A., & Weiser, J. N. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81888 · Cited by 36
Self-citation
Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice
Shen, P., Morissette, M. C., Vanderstocken, G., Gao, Y., Hassan, M. S., Roos, A. B., Thayaparan, D., Merlano, M., Dorrington, M. G., Nikota, J. K., et al. (2016) · Infection and Immunity · doi:10.1128/iai.01504-15 · Cited by 31
Hijacking host components for bacterial biofilm formation: An advanced mechanism
Mirzaei, R., & Ranjbar, R. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108471 · Cited by 30
Pneumococcal carriage and acute otitis media induce serum antibodies to pneumococcal surface proteins CbpA and PhtD in children
Simell, B., Ahokas, P., Lahdenkari, M., POOLMAN, J. T., Henckaerts, I., Kilpi, T. M., & Käyhty, H. M. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.05.071 · Cited by 30
Mouse models for the study of mucosal vaccination against otitis media
Sabirov, A., & Metzger, D. W. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.01.029 · Cited by 30
Type I Interferon Signaling Is a Common Factor Driving Streptococcus pneumoniae and Influenza A Virus Shedding and Transmission
Zangari, T., Ortigoza, M. B., Lokken-Toyli, K. L., & Weiser, J. N. (2021) · mBio · doi:10.1128/mbio.03589-20 · Cited by 28
Self-citation
Serum Antipneumococcal Antibodies and Pneumococcal Colonization in Adults with Chronic Obstructive Pulmonary Disease
Malley, R., Lipsitch, M., Bogaert, D., Thompson, C. M., Hermans, P. W. M., Watkins, A. C., Sethi, S., & Murphy, T. F. (2007) · The Journal of Infectious Diseases · doi:10.1086/520937 · Cited by 29
Pneumococcal colonisation is an asymptomatic event in healthy adults using an experimental human colonisation model
Trimble, A., Connor, V., Robinson, R., McLenaghan, D., Hancock, C. A., Wang, D., Gordon, S. B., Ferreira, D. M., Wright, A. D., & Collins, A. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229558 · Cited by 27
Combination therapy with ampicillin and azithromycin in an experimental pneumococcal pneumonia is bactericidal and effective in down regulating inflammation in mice
Majhi, A., Kundu, K., Adhikary, R., Banerjee, M., Mahanti, S., Basu, A., & Bishayi, B. (2014) · Journal of Inflammation · doi:10.1186/1476-9255-11-5 · Cited by 26
Antibodies to Pneumococcal Surface Protein A Families 1 and 2 in Serum and Saliva of Children and the Risk of Pneumococcal Acute Otitis Media
Simell, B., Melin, M. M., Lahdenkari, M., Briles, D. E., Hollingshead, S. K., Kilpi, T. M., & Käyhty, H. M. (2007) · The Journal of Infectious Diseases · doi:10.1086/522607 · Cited by 26
Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Puchta, A., Verschoor, C. P., Thurn, T., & Bowdish, D. M. E. (2014) · Journal of Visualized Experiments · doi:10.3791/50490 · Cited by 29
Coinfection with Streptococcus pneumoniae Modulates the B Cell Response to Influenza Virus
Wolf, A. I., Strauman, M. C., Mozdzanowska, K., Whittle, J. R. R., Williams, K. L., Sharpe, A. H., Weiser, J. N., Caton, A. J., Hensley, S. E., & Erikson, J. (2014) · Journal of Virology · doi:10.1128/jvi.01833-14 · Cited by 25
Self-citation
MicroRNA-155 Is Required for Clearance of Streptococcus pneumoniae from the Nasopharynx
Verschoor, C. P., Dorrington, M. G., Novakowski, K. E., Kaiser, J., Radford, K., Nair, P. K., Anipindi, V. C., Kaushic, C., Surette, M. G., & Bowdish, D. M. E. (2014) · Infection and Immunity · doi:10.1128/iai.02251-14 · Cited by 26
Tolerance of a Phage Element by Streptococcus pneumoniae Leads to a Fitness Defect during Colonization
DeBardeleben, H. K., Lysenko, E. S., Dalia, A. B., & Weiser, J. N. (2014) · Journal of Bacteriology · doi:10.1128/jb.01556-14 · Cited by 24
Self-citation
Future Perspective on Host–Pathogen Interactions During Bacterial Biofilm Formation within the Nasopharynx
Blanchette, K. A., & Orihuela, C. J. (2012) · Future Microbiology · doi:10.2217/fmb.11.160 · Cited by 24
Effects of Capsular Polysaccharide amount on Pneumococcal-Host interactions
Zhu, J., Abruzzo, A. R., Wu, C. H., Bee, G. C. W., Pironti, A., Putzel, G., Aggarwal, S. D., Eichner, H., & Weiser, J. N. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011509 · Cited by 24
Self-citation
Concomitant administration of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae serotype 19A colonization in a murine model
Whaley, M. J., Sampson, J. S., Johnson, S. E., Rajam, G., Stinson-Parks, A., Holder, P. F., Mauro, E., Romero‐Steiner, S., Carlone, G. M., & Ades, E. W. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.02.086 · Cited by 24
CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens
Sharma, S., Roumanes, D., Almudevar, A., Mosmann, T. R., & Pichichero, M. E. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.03.060 · Cited by 24
Identification of the Targets of Cross-Reactive Antibodies Induced byStreptococcus pneumoniaeColonization
Roche, A. M., & Weiser, J. N. (2010) · Infection and Immunity · doi:10.1128/iai.01058-09 · Cited by 24
Self-citation
Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine
Babb, R., Chen, A., Ogunniyi, A. D., Hirst, T. R., Kara, E. E., McColl, S. R., Alsharifi, M., & Paton, J. C. (2016) · Clinical Science · doi:10.1042/cs20160475 · Cited by 25
The Impact of the Heptavalent Pneumococcal Conjugate Vaccine on Risk Factors for Streptococcus pneumoniae Carriage in Children
Hsieh, Y., Chiu, C., Chang, K.-Y., Huang, Y., Chen, C., Kuo, C.-Y., Chen, P.-Y., Hwang, K., & Lin, T. (2012) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31825cb9f9 · Cited by 23

Authors: McCool, T. L., & Weiser, J. N.
Affiliations: University of Pennsylvania (US)
Corresponding author: Weiser, Jeffrey N.
ORCID: Weiser, Jeffrey N.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2004-10
Volume: 72
Issue: 10
Pages: 5807-5813
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.72.10.5807-5813.2004
PMC: PMC517579
OpenAlex: W2153114735
Cited by: 153
References: 37
Citations by year: 2026: 5 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 13 · 2013: 6 · 2012: 14
FWCI: 6.23
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01ai30040-13-0-5)
National Institute of Allergy and Infectious Diseases (R01AI038446, AI 38446, R21AI044231, F32AI051115, AI30040, AI51115, R01AI044231, AI44231, N01 AI030040)
Topics: Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords: Streptococcus pneumoniae, pneumococcal carriage, antibody-mediated clearance, humoral immunity, xid mice, B cell deficiency, polysaccharide antigens, mucosal antibodies, inbred mouse strains
MeSH terms: Animals, Antibodies, Bacterial, Antibody Formation, Antibody Specificity, Antigens, Bacterial, B-Lymphocytes, Bacterial Proteins, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Humans, Immune Sera, Immunoglobulin Isotypes, Mice, Inbred Strains, Pneumococcal Infections, Species Specificity, Streptococcus pneumoniae, Immunity, Mucosal, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks