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Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization
Open accessAbstract
Colonization is the first step in the interaction between Streptococcus pneumoniae and its human host. To better understand the mechanisms contributing to natural carriage, a mouse model of pneumococcal colonization was developed with a clinical isolate of S. pneumoniae previously characterized in experimental colonization of humans. Similar to carriage events in humans, colonization of mice was self-limited and there was no evidence of lower respiratory tract or invasive disease. Carriage induced a serum antibody response to whole pneumococci that was associated temporally with clearance of colonization in three inbred strains of mice. Individual mice, however, did not demonstrate a correlation between the density of colonization and amounts of serum or of mucosal antibodies, including antibodies of different isotypes and antigenic specificities. The role of antibody in the clearance of carriage was then examined in mice with genetic defects in humoral immunity. xid mice, which have deficient responses to polysaccharide antigens, cleared colonization at the same rate as the parent strain. Finally, we showed that μMT mice, which lack mature B cells and fail to produce antibody, were unaffected in the density or duration of colonization. These results demonstrate that antibody is not required for clearance of pneumococcal colonization in mice.
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“Strain P1121, a type 23F isolate obtained from a study of experimental human colonization, was selected for its ability to efficiently colonize the murine nasopharynx (15,16,18).”
From Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice (2011) · cites this paper as [16]
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Metadata
- Authors
- McCool, T. L., & Weiser, J. N.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Weiser, Jeffrey N.
- ORCID
- Weiser, Jeffrey N.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2004-10
- Volume
- 72
- Issue
- 10
- Pages
- 5807-5813
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC517579
- OpenAlex
- W2153114735
- Cited by
- 153
- References
- 37
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 13 · 2013: 6 · 2012: 14
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01ai30040-13-0-5)
- National Institute of Allergy and Infectious Diseases (R01AI038446, AI 38446, R21AI044231, F32AI051115, AI30040, AI51115, R01AI044231, AI44231, N01 AI030040)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Streptococcus pneumoniae, pneumococcal carriage, antibody-mediated clearance, humoral immunity, xid mice, B cell deficiency, polysaccharide antigens, mucosal antibodies, inbred mouse strains
- MeSH terms
- Animals, Antibodies, Bacterial, Antibody Formation, Antibody Specificity, Antigens, Bacterial, B-Lymphocytes, Bacterial Proteins, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Humans, Immune Sera, Immunoglobulin Isotypes, Mice, Inbred Strains, Pneumococcal Infections, Species Specificity, Streptococcus pneumoniae, Immunity, Mucosal, Mice
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