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Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice
Open accessAbstract
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.
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Cited by
The role of pyocyanin in Pseudomonas aeruginosa infection
Lau, G. W., Hassett, D. J., Ran, H., & Kong, F. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.10.002 · Cited by 688
Self-citationRecognition of Host Immune Activation by Pseudomonas aeruginosa
Wu, L., Estrada, O., Zaborina, O., Bains, M., Shen, L., Kohler, J. E., Patel, N., Musch, M. W., Chang, E. B., Fu, Y.-X., et al. (2005) · Science · doi:10.1126/science.1112422 · Cited by 331
Allen, L., Dockrell, D. H., Pattery, T., Lee, D. G., Cornelis, P., Hellewell, P. G., & Whyte, M. K. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3643 · Cited by 257
Phenazine-1-carboxylic acid promotes bacterial biofilm development via ferrous iron acquisition
Wang, Y., Wilks, J. C., Danhorn, T., Ramos, I., Croal, L., & Newman, D. K. (2011) · Journal of Bacteriology · doi:10.1128/jb.00396-11 · Cited by 239
Yoon, S. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24684 · Cited by 212
Metadata
- Authors
- Lau, G. W., Ran, H., Kong, F., Hassett, D. J., & Mavrodi, D.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2004-07
- Volume
- 72
- Issue
- 7
- Pages
- 4275-4278
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2133985721
- Cited by
- 368
- References
- 0
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Lau, G. W., Ran, H., Kong, F., Hassett, D. J., & Mavrodi, D. (2004). Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice. Infection and Immunity. https://doi.org/10.1128/iai.72.7.4275-4278.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
