The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Recognition of Host Immune Activation by Pseudomonas aeruginosa
Abstract
It is generally reasoned that lethal infections caused by opportunistic pathogens develop permissively by invading a host that is both physiologically stressed and immunologically compromised. However, an alternative hypothesis might be that opportunistic pathogens actively sense alterations in host immune function and respond by enhancing their virulence phenotype. We demonstrate that interferon-γ binds to an outer membrane protein in Pseudomonas aeruginosa , OprF, resulting in the expression of a quorum-sensing dependent virulence determinant, the PA-I lectin. These observations provide details of the mechanisms by which prokaryotic organisms are directly signaled by immune activation in their eukaryotic host.
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
Stover, C. K., Pham, X. Q., Erwin, A. L., Mizoguchi, S. D., Warrener, P., Hickey, M. J., Brinkman, F. S. L., Hufnagle, W. O., Kowalik, D. J., Lagrou, M., et al. (2000) · Nature · doi:10.1038/35023079 · Cited by 4,573
Self-citationComprehensive transposon mutant library of Pseudomonas aeruginosa
Jacobs, M. A., Alwood, A., Thaipisuttikul, I., Spencer, D., Haugen, E., Ernst, S., Will, O., Kaul, R., Raymond, C., Levy, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2036282100 · Cited by 1,126
Self-citationQuinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
Pesci, E. C., Milbank, J. B. J., Pearson, J. P., McKnight, S., Kende, A. S., Greenberg, E. P., & Iglewski, B. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11229 · Cited by 1,113
Wagner, V. E., Bushnell, D., Passador, L., Brooks, A. I., & Iglewski, B. H. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.7.2080-2095.2003 · Cited by 920
Environmental signals controlling expression of virulence determinants in bacteria
Mekalanos, J. J. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.1.1-7.1992 · Cited by 788
Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa
Whiteley, M., Lee, K. M., & Greenberg, E. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13904 · Cited by 650
Diggle, S. P., Winzer, K., Chhabra, S. R., Worrall, K. E., Cámara, M., & Williams, P. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03672.x · Cited by 622
Genes Lost and Genes Found: Evolution of Bacterial Pathogenesis and Symbiosis
Ochman, H., & Moran, N. A. (2001) · Science · doi:10.1126/science.1058543 · Cited by 566
Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice
Lau, G. W., Ran, H., Kong, F., Hassett, D. J., & Mavrodi, D. (2004) · Infection and Immunity · doi:10.1128/iai.72.7.4275-4278.2004 · Cited by 368
Diggle, S. P., Winzer, K., Lazdunski, A., Williams, P., & Cámara, M. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.10.2576-2586.2002 · Cited by 280
Cited by
Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712
Control of pathogens and pathobionts by the gut microbiota
Kamada, N., Chen, G. Y., Inohara, N., & Núñez, G. (2013) · Nature Immunology · doi:10.1038/ni.2608 · Cited by 1,625
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
The first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182
Garrett, W. S., Gallini, C. A., Yatsunenko, T., Michaud, M., DuBois, A., Delaney, M. L., Punit, S., Karlsson, M., Bry, L., Glickman, J. N., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.08.004 · Cited by 788
Metadata
- Authors
- Wu, L., Estrada, O., Zaborina, O., Bains, M., Shen, L., Kohler, J. E., Patel, N., Musch, M. W., Chang, E. B., Fu, Y.-X., Jacobs, M. A., Nishimura, M. I., Hancock, R. E. W., Turner, J. R., & Alverdy, J. C.
- Venue
- Science
- Published
- 2005-07-29
- Volume
- 309
- Issue
- 5735
- Pages
- 774-777
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2116527263
- Cited by
- 331
- References
- 18
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wu, L., Estrada, O., Zaborina, O., Bains, M., Shen, L., Kohler, J. E., Patel, N., Musch, M. W., Chang, E. B., Fu, Y.-X., Jacobs, M. A., Nishimura, M. I., Hancock, R. E. W., Turner, J. R., & Alverdy, J. C. (2005). Recognition of Host Immune Activation by Pseudomonas aeruginosa. Science. https://doi.org/10.1126/science.1112422
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
