The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium
Open accessAbstract
Salmonella typhimurium synthesizes cobalamin (vitamin B12) de novo under anaerobic conditions. Of the 30 cobalamin synthetic genes, 25 are clustered in one operon, cob, and are arranged in three groups, each group encoding enzymes for a biochemically distinct portion of the biosynthetic pathway. We have determined the DNA sequence for the promoter region and the proximal 17.1 kb of the cob operon. This sequence includes 20 translationally coupled genes that encode the enzymes involved in parts I and III of the cobalamin biosynthetic pathway. A comparison of these genes with the cobalamin synthetic genes from Pseudomonas denitrificans allows assignment of likely functions to 12 of the 20 sequenced Salmonella genes. Three additional Salmonella genes encode proteins likely to be involved in the transport of cobalt, a component of vitamin B12. However, not all Salmonella and Pseudomonas cobalamin synthetic genes have apparent homologs in the other species. These differences suggest that the cobalamin biosynthetic pathways differ between the two organisms. The evolution of these genes and their chromosomal positions is discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Modern metabolism as a palimpsest of the RNA world
Benner, S. A., Ellington, A. D., & Tauer, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7054 · Cited by 478
Vitamin B12: Experiments Concerning the Origin of Its Molecular Structure
Eschenmoser, A. (1988) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198800051 · Cited by 374
Cited by
Comparative Genomics of the Vitamin B12 Metabolism and Regulation in Prokaryotes
Rodionov, D. A., Vitreschak, A. G., Mironov, A. A., & Gelfand, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305837200 · Cited by 472
Biosynthesis of the modified tetrapyrroles—the pigments of life
Bryant, D. A., Hunter, C. N., & Warren, M. J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.006194 · Cited by 303
Santoro, A. E., Dupont, C. L., Richter, R. A., Craig, M. T., Carini, P., McIlvin, M. R., Yang, Y., Orsi, W. D., Moran, D. M., & Saito, M. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416223112 · Cited by 268
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea
Zheng, K., Ngo, P. D., Owens, V. L., Yang, X.-P., & Mansoorabadi, S. O. (2016) · Science · doi:10.1126/science.aag2947 · Cited by 153
Zhang, Y., & Gladyshev, V. N. (2009) · Chemical Reviews · doi:10.1021/cr800557s · Cited by 143
Metadata
- Authors
- Roth, J. R., Lawrence, J. G., Rubenfield, M., Kieffer-Higgins, S., & Church, G. M.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1993-06
- Volume
- 175
- Issue
- 11
- Pages
- 3303-3316
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2128750592
- Cited by
- 281
- References
- 4
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. https://app.cochat.ai/papers/10.1128/jb.175.11.3303-3316.1993
- The paper
- Roth, J. R., Lawrence, J. G., Rubenfield, M., Kieffer-Higgins, S., & Church, G. M. (1993). Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. Journal of Bacteriology. https://doi.org/10.1128/jb.175.11.3303-3316.1993
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
