The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium
Open accessAbstract
Salmonella typhimurium synthesizes cobalamin (vitamin B12) de novo under anaerobic conditions. Of the 30 cobalamin synthetic genes, 25 are clustered in one operon, cob, and are arranged in three groups, each group encoding enzymes for a biochemically distinct portion of the biosynthetic pathway. We have determined the DNA sequence for the promoter region and the proximal 17.1 kb of the cob operon. This sequence includes 20 translationally coupled genes that encode the enzymes involved in parts I and III of the cobalamin biosynthetic pathway. A comparison of these genes with the cobalamin synthetic genes from Pseudomonas denitrificans allows assignment of likely functions to 12 of the 20 sequenced Salmonella genes. Three additional Salmonella genes encode proteins likely to be involved in the transport of cobalt, a component of vitamin B12. However, not all Salmonella and Pseudomonas cobalamin synthetic genes have apparent homologs in the other species. These differences suggest that the cobalamin biosynthetic pathways differ between the two organisms. The evolution of these genes and their chromosomal positions is discussed.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
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Modern metabolism as a palimpsest of the RNA world
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Vitamin B12: Experiments Concerning the Origin of Its Molecular Structure
Eschenmoser, A. (1988) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198800051 · Cited by 374
Cited by
Comparative Genomics of the Vitamin B12 Metabolism and Regulation in Prokaryotes
Rodionov, D. A., Vitreschak, A. G., Mironov, A. A., & Gelfand, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305837200 · Cited by 472
Biosynthesis of the modified tetrapyrroles—the pigments of life
Bryant, D. A., Hunter, C. N., & Warren, M. J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.006194 · Cited by 303
Santoro, A. E., Dupont, C. L., Richter, R. A., Craig, M. T., Carini, P., McIlvin, M. R., Yang, Y., Orsi, W. D., Moran, D. M., & Saito, M. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416223112 · Cited by 268
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea
Zheng, K., Ngo, P. D., Owens, V. L., Yang, X.-P., & Mansoorabadi, S. O. (2016) · Science · doi:10.1126/science.aag2947 · Cited by 153
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The anaerobic biosynthesis of vitamin B12
Moore, S. J., & Warren, M. J. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120066 · Cited by 91
Evolution of enzymes and pathways for the biosynthesis of cofactors
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Self-citationArchaeoglobus fulgidus CbiX S is a Cobalt Chelatase Where Co(II) is Ligated by His10 and His74
Morris, J. A., Ayodele-Davis, O. O. E., Lavigne, M. E., Martorelli Di Genova, B., & Liptak, M. D. (2026) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.6c00056 · Cited by 3
Metadata
- Authors
- Roth, J. R., Lawrence, J. G., Rubenfield, M., Kieffer-Higgins, S., & Church, G. M.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1993-06
- Volume
- 175
- Issue
- 11
- Pages
- 3303-3316
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2128750592
- Cited by
- 281
- References
- 4
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
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