The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
The Developmentally Regulated alb1 Gene of Aspergillus fumigatus: Its Role in Modulation of Conidial Morphology and Virulence
Open accessAbstract
Aspergillus fumigatus, an important opportunistic pathogen which commonly affects neutropenic patients, produces conidia with a bluish-green color. We identified a gene,alb1, which is required for conidial pigmentation. The alb1 gene encodes a putative polyketide synthase, and disruption of alb1 resulted in an albino conidial phenotype. Expression of alb1 is developmentally regulated, and the 7-kb transcript is detected only during the conidiation stage. The alb1 mutation was found to block 1,3,6,8-tetrahydroxynaphthalene production, indicating that alb1 is involved in dihydroxynaphthalene-melanin biosynthesis. Scanning electron microscopy studies showed that the alb1 disruptant exhibited a smooth conidial surface, whereas complementation of the alb1 deletion restored the echinulate wild-type surface. Disruption of alb1 resulted in a significant increase in C3 binding on conidial surfaces, and the conidia of the alb1 disruptant were ingested by human neutrophils at a higher rate than were those of the wild type. The alb1-complemented strain producing bluish-green conidia exhibited inefficient C3 binding and neutrophil-mediated phagocytosis quantitatively similar to those of the wild type. Importantly, the alb1 disruptant had a statistically significant loss of virulence compared to the wild-type and alb1-complemented strains in a murine model. These results suggest that disruption of alb1 causes pleiotropic effects on conidial morphology and fungal virulence.
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Metadata
- Authors
- Tsai, H.-F., Chang, Y. C., Washburn, R. G., Wheeler, M. H., & Kwon-Chung, K. J.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1998-06-15
- Volume
- 180
- Issue
- 12
- Pages
- 3031-3038
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2135280679
- Cited by
- 334
- References
- 67
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Tsai, H.-F., Chang, Y. C., Washburn, R. G., Wheeler, M. H., & Kwon-Chung, K. J. (1998). The Developmentally Regulated alb1 Gene of Aspergillus fumigatus: Its Role in Modulation of Conidial Morphology and Virulence. Journal of Bacteriology. https://doi.org/10.1128/jb.180.12.3031-3038.1998
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