The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Deletion of the Alternative Sigma Factor ς B in Staphylococcus aureus Reveals Its Function as a Global Regulator of Virulence Genes
Open accessAbstract
A deletion of the sigB operon was constructed in three genetically distinct Staphylococcus aureus strains, and the phenotypes of the resulting mutants were analyzed. Compared to the corresponding wild-type strains, the Δ sigB mutants showed reduced pigmentation, accelerated sedimentation, and increased sensitivity to hydrogen peroxide during the stationary growth phase. A cytoplasmic protein missing in the Δ sigB mutants was identified as alkaline shock protein 23, and an extracellular protein excreted at higher levels in one of the Δ sigB mutants was identified as staphylococcal thermonuclease. Interestingly, most sigB deletion phenotypes were only seen in S. aureus COL and Newman and not in 8325, which was found to contain an 11-bp deletion in the regulator gene rsbU . Taken together, our results show that ς B is a global regulator which modulates the expression of several virulence factors in S. aureus and that laboratory strain 8325 is a ς B -defective mutant.
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“σB is a product of sigB operon and is the main regulator of S. aureus response to environmental stress.”
From A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism (2022) · cites this paper as [112]
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Cited by
Biofilm formation as microbial development
O'Toole, G., Kaplan, H. B., & Kolter, R. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.49 · Cited by 3,571
Surviving the Acid Test: Responses of Gram-Positive Bacteria to Low pH
Cotter, P. D., & Hill, C. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.3.429-453.2003 · Cited by 1,379
Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia
Labandeira-Rey, M., Couzon, F., Boisset, S., Brown, E. L., Bes, M., Benito, Y., Barbu, E. M., Vazquez, V., Höök, M., Etienne, J., et al. (2007) · Science · doi:10.1126/science.1137165 · Cited by 709
Horsburgh, M. J., Aish, J. L., White, I. J., Shaw, L., Lithgow, J. K., & Foster, S. J. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.19.5457-5467.2002 · Cited by 699
Regulation of Staphylococcus aureus Virulence
Jenul, C., & Horswill, A. R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0031-2018 · Cited by 549
Metadata
- Authors
- Kullik, I., Giachino, P., & Fuchs, T.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1998-09-15
- Volume
- 180
- Issue
- 18
- Pages
- 4814-4820
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1982777646
- Cited by
- 324
- References
- 29
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Kullik, I., Giachino, P., & Fuchs, T. (1998). Deletion of the Alternative Sigma Factor ς B in Staphylococcus aureus Reveals Its Function as a Global Regulator of Virulence Genes. Journal of Bacteriology. https://doi.org/10.1128/jb.180.18.4814-4820.1998
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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