The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance
Open accessAbstract
The effects of simultaneous expression of several efflux pumps on antibiotic resistance were investigated in Escherichia coli and Pseudomonas aeruginosa . Several combinations of efflux pumps have been studied: (i) simultaneous expression of a single-component efflux pump, which exports antibiotics into the periplasm, in combination with a multicomponent efflux pump that accomplishes efflux directly into the external medium; (ii) simultaneous expression of two single-component pumps; and (iii) simultaneous expression of two multicomponent pumps. It was found that when efflux pumps of different structural types were combined in the same cell (the first case), the observed antibiotic resistance was much higher than that conferred by each of the pumps expressed singly. Simultaneous expression of pairs of single-component or multicomponent efflux pumps (the second and third cases) did not produce strong increases in antibiotic resistance.
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Citations
Cites
Tetracyclines: Antibiotic action, uptake, and resistance mechanisms
Schnappinger, D., & Hillen, W. (1996) · Archives of Microbiology · doi:10.1007/s002030050339 · Cited by 484
Antibiotic Resistance Caused by Gram‐Negative Multidrug Efflux Pumps
Nikaido, H. (1998) · Clinical Infectious Diseases · doi:10.1086/514920 · Cited by 348
Cited by
Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?
Livermore, D. M. (2002) · Clinical Infectious Diseases · doi:10.1086/338782 · Cited by 1,453
Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It
Zgurskaya, H. I., López, C. A., & Gnanakaran, S. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00097 · Cited by 580
Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria
Nikaido, H. (2001) · Seminars in Cell & Developmental Biology · doi:10.1006/scdb.2000.0247 · Cited by 317
The Gram-negative permeability barrier: tipping the balance of the in and the out
Maher, C., & Hassan, K. A. (2023) · mBio · doi:10.1128/mbio.01205-23 · Cited by 194
EmrE, a model for studying evolution and mechanism of ion-coupled transporters
Schuldiner, S. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.12.018 · Cited by 164
Metadata
- Authors
- Lee, A., Mao, W., Warren, M. S., Mistry, A., Hoshino, K., Okumura, R., Ishida, H., & Lomovskaya, O.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2000-06
- Volume
- 182
- Issue
- 11
- Pages
- 3142-3150
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2022802506
- Cited by
- 263
- References
- 2
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Lee, A., Mao, W., Warren, M. S., Mistry, A., Hoshino, K., Okumura, R., Ishida, H., & Lomovskaya, O. (2000). Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance. Journal of Bacteriology. https://doi.org/10.1128/jb.182.11.3142-3150.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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