The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Correlations between Shine-Dalgarno Sequences and Gene Features Such as Predicted Expression Levels and Operon Structures
Open accessAbstract
This work assesses relationships for 30 complete prokaryotic genomes between the presence of the Shine-Dalgarno (SD) sequence and other gene features, including expression levels, type of start codon, and distance between successive genes. A significant positive correlation of the presence of an SD sequence and the predicted expression level of a gene based on codon usage biases was ascertained, such that predicted highly expressed genes are more likely to possess a strong SD sequence than average genes. Genes with AUG start codons are more likely than genes with other start codons, GUG or UUG, to possess an SD sequence. Genes in close proximity to upstream genes on the same coding strand in most genomes are significantly higher in SD presence. In light of these results, we discuss the role of the SD sequence in translation initiation and its relationship with predicted gene expression levels and with operon structure in both bacterial and archaeal genomes.
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Krishnamurthy, S. R., & Wang, D. (2018) · Virology · doi:10.1016/j.virol.2018.01.006 · Cited by 106
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Bartholomäus, A., Fedyunin, I., Feist, P., Sin, C., Zhang, G., Valleriani, A., & Ignatova, Z. (2016) · Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2015.0069 · Cited by 81
Metadata
- Authors
- Ma, J., Campbell, A., & Karlin, S.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2002-10-15
- Volume
- 184
- Issue
- 20
- Pages
- 5733-5745
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1969422740
- Cited by
- 314
- References
- 54
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Ma, J., Campbell, A., & Karlin, S. (2002). Correlations between Shine-Dalgarno Sequences and Gene Features Such as Predicted Expression Levels and Operon Structures. Journal of Bacteriology. https://doi.org/10.1128/jb.184.20.5733-5745.2002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
