Cited by 211Microbial Metabolic Engineering and BioproductionAlgal biology and biofuel productionPlant biochemistry and biosynthesis

Application of synthetic biology in cyanobacteria and algae

Open access
Wang, Bo, Wang, Jiangxin, Zhang, Weiwen, Meldrum, Deirdre R.·2012·Frontiers in Microbiology

Abstract

Cyanobacteria and algae are becoming increasingly attractive cell factories for producing renewable biofuels and chemicals due to their ability to capture solar energy and CO(2) and their relatively simple genetic background for genetic manipulation. Increasing research efforts from the synthetic biology approach have been made in recent years to modify cyanobacteria and algae for various biotechnological applications. In this article, we critically review recent progresses in developing genetic tools for characterizing or manipulating cyanobacteria and algae, the applications of genetically modified strains for synthesizing renewable products such as biofuels and chemicals. In addition, the emergent challenges in the development and application of synthetic biology for cyanobacteria and algae are also discussed.

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Crossref · 10.3389/fmicb.2012.00344

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  • Native promoters, often sourced from cyanobacterial genes related to photosynthesis, carbon metabolism, or stress responses, are frequently used due to their compatibility with the host's transcriptional machinery.

    “Native promoters, often sourced from cyanobacterial genes related to photosynthesis, carbon metabolism, or stress responses, are frequently used due to their compatibility with the host’s transcriptional machinery [98].”

    From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [98]

    The “Development of BioBricks” section says native cyanobacterial promoters used are usually from photosynthesis-related genes, including those involved in CO₂ fixation, and gives a nickel-inducible promoter as another example. It notes that foreign E. coli promoters may behave differently in cyanobacteria, but does not say native promoters are frequently used because of compatibility with host transcriptional machinery or identify stress-response genes as a usual source. (LLM, conf=0.84)

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Research works printed but not linked: 2

  1. Benner S. (2003). Act natural. Nature 421 118 12520282
  2. Energy Information Administration. (2010). Annual Energy Review 2009, U.S.

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Authors
Wang, B., Wang, J., Zhang, W., & Meldrum, D. R.
Affiliations
Arizona State University (US)
Corresponding author
Wang, Bo
Venue
Frontiers in Microbiology
Published
2012
Volume
3
Pages
344-344
ISSN
1664-302X (ISSN-L)
OpenAlex
W2061453352
Cited by
211
References
213
Citations by year
2026: 6 · 2025: 6 · 2024: 12 · 2023: 9 · 2022: 10 · 2021: 19 · 2020: 16 · 2019: 19 · 2018: 17 · 2017: 17 · 2016: 15 · 2015: 24 · 2014: 25 · 2013: 15 · 2012: 1
FWCI
8.36
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Key Research and Development Program of China (2011CBA00803)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Keywords
synthetic biology, cyanobacteria, algae, genetic instruments, genetically modified microorganisms, biofuels, renewable chemicals, cell factories, CO2 fixation, solar energy conversion

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