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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

A Genomic Perspective on Protein Families

Tatusov, Roman L., Koonin, Eugene V., Lipman, David J.·1997·Science
DOI 10.1126/science.278.5338.631
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Abstract

In order to extract the maximum amount of information from the rapidly accumulating genome sequences, all conserved genes need to be classified according to their homologous relationships. Comparison of proteins encoded in seven complete genomes from five major phylogenetic lineages and elucidation of consistent patterns of sequence similarities allowed the delineation of 720 clusters of orthologous groups (COGs). Each COG consists of individual orthologous proteins or orthologous sets of paralogs from at least three lineages. Orthologs typically have the same function, allowing transfer of functional information from one member to an entire COG. This relation automatically yields a number of functional predictions for poorly characterized genomes. The COGs comprise a framework for functional and evolutionary genome analysis.

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Metadata

Authors
Tatusov, R. L., Koonin, E. V., & Lipman, D. J.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1997-10-24
Volume
278
Issue
5338
Pages
631-637
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.278.5338.631
OpenAlex
W1990453950
Cited by
3,590
References
5
FWCI
27.90
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Genomic Perspective on Protein Families. https://app.cochat.ai/papers/10.1126/science.278.5338.631
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Tatusov, R. L., Koonin, E. V., & Lipman, D. J. (1997). A Genomic Perspective on Protein Families. Science. https://doi.org/10.1126/science.278.5338.631

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