The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Secretion of Virulence Proteins from Campylobacter jejuni Is Dependent on a Functional Flagellar Export Apparatus
Open accessAbstract
Campylobacter jejuni , a gram-negative motile bacterium, secretes a set of proteins termed the Campylobacter invasion antigens (Cia proteins). The purpose of this study was to determine whether the flagellar apparatus serves as the export apparatus for the Cia proteins. Mutations were generated in five genes encoding three structural components of the flagella, the flagellar basal body ( flgB and flgC ), hook ( flgE2 ), and filament ( flaA and flaB ) genes, as well as in genes whose products are essential for flagellar protein export ( flhB and fliI ). While mutations that affected filament assembly were found to be nonmotile (Mot − ) and did not secrete Cia proteins (S − ), a flaA ( flaB + ) filament mutant was found to be nonmotile but Cia protein secretion competent (Mot − , S + ). Complementation of a flaA flaB double mutant with a shuttle plasmid harboring either the flaA or flaB gene restored Cia protein secretion, suggesting that Cia export requires at least one of the two filament proteins. Infection of INT 407 human intestinal cells with the C. jejuni mutants revealed that maximal invasion of the epithelial cells required motile bacteria that are secretion competent. Collectively, these data suggest that the C. jejuni Cia proteins are secreted from the flagellar export apparatus.
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The Virulence Plasmid of Yersinia, an Antihost Genome
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Regulation of flagellar assembly
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Self-citation
Cited by
Campylobacter flagella: not just for motility
Guerry, P. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.09.006 · Cited by 339
Propulsive nanomachines: the convergent evolution of archaella, flagella and cilia
Beeby, M., Ferreira, J. L., Tripp, P., Albers, S.-V., & Mitchell, D. R. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa006 · Cited by 110
Nedeljković, M., Kreutzberger, M. A. B., Postel, S., Bonsor, D., Xing, Y., Jacob, N., Schuler, W. J., Egelman, E. H., & Sundberg, E. J. (2023) · PLOS Pathogens · doi:10.1371/journal.ppat.1010979 · Cited by 13
Metadata
- Authors
- Konkel, M. E., Klena, J. D., Rivera-Amill, V., Monteville, M. R., Biswas, D., Raphael, B., & Mickelson, J.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2004-06
- Volume
- 186
- Issue
- 11
- Pages
- 3296-3303
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1991998717
- Cited by
- 366
- References
- 39
- FWCI
- 26.64
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Konkel, M. E., Klena, J. D., Rivera-Amill, V., Monteville, M. R., Biswas, D., Raphael, B., & Mickelson, J. (2004). Secretion of Virulence Proteins from Campylobacter jejuni Is Dependent on a Functional Flagellar Export Apparatus. Journal of Bacteriology. https://doi.org/10.1128/jb.186.11.3296-3303.2004
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