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Cited by 233

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Identification of a Broadly Active Phage Lytic Enzyme with Lethal Activity against Antibiotic-Resistant Enterococcus faecalis and Enterococcus faecium

Open access
Yoong, Pauline, Schuch, Raymond, Nelson, Daniel, Fischetti, Vincent A.·2004·Journal of Bacteriology
DOI 10.1128/jb.186.14.4808-4812.2004
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Abstract

Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and shown to effectively kill both E. faecalis and E. faecium (including vancomycin-resistant strains), as well as other human pathogens. We propose its development and use as an alternative therapeutic tool.

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Metadata

Authors
Yoong, P., Schuch, R., Nelson, D., & Fischetti, V. A.
Venue
Journal of Bacteriology
Publisher
American Society for Microbiology
Published
2004-07-15
Volume
186
Issue
14
Pages
4808-4812
ISSN
  • 0021-9193 (ISSN-L)
  • 1098-5530
DOI
10.1128/jb.186.14.4808-4812.2004
OpenAlex
W2118206090
Cited by
233
References
0
FWCI
5.66
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Identification of a Broadly Active Phage Lytic Enzyme with Lethal Activity against Antibiotic-Resistant Enterococcus faecalis and Enterococcus faecium. https://app.cochat.ai/papers/10.1128/jb.186.14.4808-4812.2004
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Yoong, P., Schuch, R., Nelson, D., & Fischetti, V. A. (2004). Identification of a Broadly Active Phage Lytic Enzyme with Lethal Activity against Antibiotic-Resistant Enterococcus faecalis and Enterococcus faecium. Journal of Bacteriology. https://doi.org/10.1128/jb.186.14.4808-4812.2004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.