The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Effect of RyhB Small RNA on Global Iron Use in Escherichia coli
Open accessAbstract
RyhB is a noncoding RNA regulated by the Fur repressor. It has previously been shown to cause the rapid degradation of a number of mRNAs that encode proteins that utilize iron. Here we examine the effect of ectopic RyhB production on global gene expression by microarray analysis. Many of the previously identified targets were found, as well as other mRNAs encoding iron-binding proteins, bringing the total number of regulated operons to at least 18, encoding 56 genes. The two major operons involved in Fe-S cluster assembly showed different behavior; the isc operon appears to be a direct target of RyhB action, while the suf operon does not. This is consistent with previous findings suggesting that the suf genes but not the isc genes are important for Fe-S cluster synthesis under iron-limiting conditions, presumably for essential iron-binding proteins. In addition, we observed repression of Fur-regulated genes upon RyhB expression, interpreted as due to intracellular iron sparing resulting from reduced synthesis of iron-binding proteins. Our results demonstrate the broad effects of a single noncoding RNA on iron homeostasis.
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Cites
Andrews, S. C., Robinson, A. K., & Rodríguez-Quiñones, F. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00055-x · Cited by 2,702 · cited 1×
“This metal is an integral part of heme and is used as a cofactor in Fe-S proteins involved in major biological processes such as electron transport, the trichloroacetic acid (TCA) cycle, photosynthesis, N2 fixation, gene regulation, and DNA biosynthesis (2).”
BackgroundSiderophore-Mediated Iron Transport: Crystal Structure of FhuA with Bound Lipopolysaccharide
Ferguson, A. D., Hofmann, E., Coulton, J. W., Diederichs, K., & Welte, W. (1998) · Science · doi:10.1126/science.282.5397.2215 · Cited by 787
Iron and metal regulation in bacteria
Hantke, K. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00184-3 · Cited by 755
Regulation of ferric iron transport in Escherichia coli K12: Isolation of a constitutive mutant
Hantke, K. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00269672 · Cited by 563
Characterization of the ferrous iron uptake system of Escherichia coli
Kammler, M., Schön, C., & Hantke, K. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.19.6212-6219.1993 · Cited by 460
Structural basis of gating by the outer membrane transporter FecA
Ferguson, A. D., Chakraborty, R., Smith, B. S., Esser, L., van der Helm, D., & Deisenhofer, J. (2002) · Science · doi:10.1126/science.1067313 · Cited by 373
Recognition of DNA by Fur: a Reinterpretation of the Fur Box Consensus Sequence
Baichoo, N., & Helmann, J. D. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.21.5826-5832.2002 · Cited by 282 · cited 1×
“The Fur-binding consensus contains three or four imperfect adjacent hexamers 5 -GATAAT-3 (10, 27), although an alternative consensus sequence (5 -TGATAATNA TTATCA-3 ) has been proposed recently (4).”
BackgroundArchitecture of a Fur Binding Site: a Comparative Analysis
Lavrrar, J. L., & McIntosh, M. A. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.7.2194-2202.2003 · Cited by 95
Cited by
Metal homeostasis and resistance in bacteria
Chandrangsu, P., Rensing, C., & Helmann, J. D. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.15 · Cited by 812
Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria
Troxell, B., & Hassan, H. M. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00059 · Cited by 500
Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions
Westermann, A. J., Förstner, K. U., Amman, F., Barquist, L., Chao, Y., Schulte, L. N., Müller, L., Reinhardt, R., Stadler, P. F., & Vogel, J. (2016) · Nature · doi:10.1038/nature16547 · Cited by 499
Functional specialization within the Fur family of metalloregulators
Lee, J.-W., & Helmann, J. D. (2007) · BioMetals · doi:10.1007/s10534-006-9070-7 · Cited by 432
Chiang, S. M., & Schellhorn, H. E. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.02.007 · Cited by 381
Metadata
- Authors
- Massé, E., Vanderpool, C. K., & Gottesman, S.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2005-10-15
- Volume
- 187
- Issue
- 20
- Pages
- 6962-6971
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2119338907
- Cited by
- 546
- References
- 8
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Massé, E., Vanderpool, C. K., & Gottesman, S. (2005). Effect of RyhB Small RNA on Global Iron Use in Escherichia coli. Journal of Bacteriology. https://doi.org/10.1128/jb.187.20.6962-6971.2005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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