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The Recombinant Phage Lysin LysK Has a Broad Spectrum of Lytic Activity against Clinically Relevant Staphylococci, Including Methicillin-Resistant Staphylococcus aureus
Open accessAbstract
This study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis . Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus . LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci.
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Citations
Cited by
Bacteriophage Endolysins as Novel Antimicrobials
Schmelcher, M., Donovan, D. M., & Loessner, M. J. (2012) · Future Microbiology · doi:10.2217/fmb.12.97 · Cited by 785
Antibiotic alternatives: the substitution of antibiotics in animal husbandry?
Cheng, G., Hao, H., Xie, S., Wang, X., Dai, M., Huang, L., & Yuan, Z. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00217 · Cited by 622
Bacteriophage lysins as effective antibacterials
Fischetti, V. A. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.09.012 · Cited by 477
Bacteriophage endolysins: A novel anti-infective to control Gram-positive pathogens
Fischetti, V. A. (2010) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.04.002 · Cited by 438
Nelson, D. C., Schmelcher, M., Rodriguez-Rubio, L., Klumpp, J., Pritchard, D. G., Dong, S., & Donovan, D. M. (2012) · Advances in Virus Research · doi:10.1016/b978-0-12-394438-2.00007-4 · Cited by 372
Metadata
- Authors
- O'Flaherty, S., Coffey, A., Meaney, W., Fitzgerald, G. F., & Ross, R. P.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2005-10-15
- Volume
- 187
- Issue
- 20
- Pages
- 7161-7164
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2047019892
- Cited by
- 234
- References
- 0
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Recombinant Phage Lysin LysK Has a Broad Spectrum of Lytic Activity against Clinically Relevant Staphylococci, Including Methicillin-Resistant Staphylococcus aureus. https://app.cochat.ai/papers/10.1128/jb.187.20.7161-7164.2005
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- O'Flaherty, S., Coffey, A., Meaney, W., Fitzgerald, G. F., & Ross, R. P. (2005). The Recombinant Phage Lysin LysK Has a Broad Spectrum of Lytic Activity against Clinically Relevant Staphylococci, Including Methicillin-Resistant Staphylococcus aureus. Journal of Bacteriology. https://doi.org/10.1128/jb.187.20.7161-7164.2005
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
