The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector
Open accessAbstract
With the widespread appearance of antibiotic-resistant bacteria, there is an increasing demand for novel strategies to control infectious diseases. Furthermore, it has become apparent that the bacterial life style also contributes significantly to this problem. Bacteria living in the biofilm mode of growth tolerate conventional antimicrobial treatments. The discovery that many bacteria use quorum-sensing (QS) systems to coordinate virulence and biofilm development has pointed out a new, promising target for antimicrobial drugs. We constructed a collection of screening systems, QS inhibitor (QSI) selectors, which enabled us to identify a number of novel QSIs among natural and synthetic compound libraries. The two most active were garlic extract and 4-nitro-pyridine- N -oxide (4-NPO). GeneChip-based transcriptome analysis revealed that garlic extract and 4-NPO had specificity for QS-controlled virulence genes in Pseudomonas aeruginosa . These two QSIs also significantly reduced P. aeruginosa biofilm tolerance to tobramycin treatment as well as virulence in a Caenorhabditis elegans pathogenesis model.
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Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Contribution of Quorum Sensing to the Virulence of Pseudomonas aeruginosa in Burn Wound Infections
Rumbaugh, K. P., Griswold, J. A., Iglewski, B. H., & Hamood, A. N. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.5854-5862.1999 · Cited by 408
Cited by
The role of bacterial biofilms in chronic infections
Bjarnsholt, T. (2013) · APMIS · doi:10.1111/apm.12099 · Cited by 1,080
Self-citationQuorum Sensing in the Context of Food Microbiology
Skandamis, P. N., & Nychas, G.-J. E. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.00468-12 · Cited by 215
Inhibition of quorum-sensing signals by essential oils
Szabó, M. Á., Varga, G. Z., Hohmann, J., Schelz, Z., Szegedi, E., Amaral, L., & Molnár, J. (2010) · Phytotherapy Research · doi:10.1002/ptr.3010 · Cited by 155
Jafari-Sabet, M., & Baratian, A. (2017) · Journal of Archives in Military Medicine · doi:10.5812/jamm.45046 · Cited by 3
Metadata
- Authors
- Rasmussen, T. B., Bjarnsholt, T., Skindersoe, M. E., Hentzer, M., Kristoffersen, P., Köte, M., Nielsen, J., Eberl, L., & Givskov, M.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2005-03
- Volume
- 187
- Issue
- 5
- Pages
- 1799-1814
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2165707370
- Cited by
- 622
- References
- 2
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- green
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