Inhibition of quorum-sensing signals by essential oils
Open accessAbstract
The role of quorum sensing (QS) is well known in microbial pathogenicity and antibiotic resistance. QS is responsible for motility, swarming, and biofilm production based on the signal molecules, e.g., acylated homoserine lactones (AHLs) produced by micro-organisms above certain population density. The inhibition of QS may reduce pathogenicity, antibiotic resistance and biofilm formation in systemic and local infections. The homoserine lactones and other transmitters contribute to antibiotic resistance and pathogenicity of several bacteria; consequently the inhibition of QS signals reduces the problem of resistance and virulence. Due to the increasing number of persistent non-treatable infections, there is an urgent need to develop new strategies to combat infections that destabilize bacterial communities in the host. The effect of essential oils on bacterial growth and QS were evaluated using the sensor strain Chromobacterium violaceum CV026 and N-acyl homoserine lactone (AHL) producing Escherichia coli ATTC 31298 and the grapevine colonizing Ezf 10-17 strains. Of the tested oils, rose, geranium, lavender and rosemary oils were the most potent QS inhibitors. Eucalyptus and citrus oils moderately reduced pigment production by CV026, whereas the chamomile, orange and juniper oils were ineffective.
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Different essential oils from ornamental plants have been observed to be effective against biofilms formed by Salmonella, Listeria, Pseudomonas, Staphylococcus and Lactobacillus spp.
“Different EOs from ornamental plants have been observed to be effective against biofilms formed by Salmonella, Listeria, Pseudomonas, Staphylococcus and Lactobacillus spp.”
From Effect of essential oils on pathogenic bacteria (2013) · cites this paper as [130]
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Cites
QUORUM SENSING: Cell-to-Cell Communication in Bacteria
Waters, C. M., & Bassler, B. L. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131001 · Cited by 3,989 · see citing works
McClean, K. H., Winson, M. K., Fish, L., Taylor, A., Chhabra, S. R., Cámara, M., Daykin, M., Lamb, J. H., Swift, S., Bycroft, B. W., et al. (1997) · Microbiology · doi:10.1099/00221287-143-12-3703 · Cited by 1,745 · see citing works
Inter-kingdom signalling: Communication between bacteria and their hosts
Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761 · see citing works
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
Hentzer, M., & Givskov, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20074 · Cited by 705 · see citing works
Quorum sensing, communication and cross-kingdom signalling in the bacterial world
Williams, P. M. (2007) · Microbiology · doi:10.1099/mic.0.2007/012856-0 · Cited by 659 · see citing works
Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector
Rasmussen, T. B., Bjarnsholt, T., Skindersoe, M. E., et al. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.5.1799-1814.2005 · Cited by 624 · see citing works
Q UORUM S ENSING IN P LANT -P ATHOGENIC B ACTERIA
von Bodman, S. B., Bauer, W. D., & Coplin, D. L. (2003) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.41.052002.095652 · Cited by 588 · see citing works
Messing with Bacterial Quorum Sensing
González, J. E., & Keshavan, N. D. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00002-06 · Cited by 429 · see citing works
Antimicrobial and antiplasmid activities of essential oils
Schelz, Z., Molnar, J. A., & Hohmann, J. (2006) · Fitoterapia · doi:10.1016/j.fitote.2006.03.013 · Cited by 421 · see citing works
Self-citationA simple screening protocol for the identification of quorum signal antagonists
McLean, R. J. C., Pierson, L. S., & Fuqua, C. (2004) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2004.04.016 · Cited by 344 · see citing works
Quiñones, B., Dulla, G. F. J., & Lindow, S. E. (2005) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-18-0682 · Cited by 301 · see citing works
AHL-driven quorum-sensing circuits: their frequency and function among the Proteobacteria
Case, R. J., Labbate, M., & Kjelleberg, S. J. (2008) · The ISME Journal · doi:10.1038/ismej.2008.13 · Cited by 299 · see citing works
Molina, L., CONSTANTINESCU, F., Michel, L., et al. (2003) · FEMS Microbiology Ecology · doi:10.1016/s0168-6496(03)00125-9 · Cited by 285 · see citing works
New horizons for (p)ppGpp in bacterial and plant physiology
Braeken, K., Moris, M., Daniels, R., Vanderleyden, J., & Michiels, J. J. (2005) · Trends in Microbiology · doi:10.1016/j.tim.2005.11.006 · Cited by 230 · see citing works
Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N -Acyl Cyclopentylamides
Ishida, T., Ikeda, T., Takiguchi, N., et al. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02233-06 · Cited by 193 · see citing works
Cell-Cell Communication in Bacteria: United We Stand
von Bodman, S. B., Willey, J. M., & Diggle, S. P. (2008) · Journal of Bacteriology · doi:10.1128/jb.00486-08 · Cited by 180 · see citing works
Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signalling
Shiner, E. K., Terentyev, D. A., Bryan, A., Sennoune, S. R., Martı́nez–Zaguilán, R., Li, G., Györke, S., Williams, S. C., & Rumbaugh, K. P. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00734.x · Cited by 159 · see citing works
Li, L., Hooi, D. S. W., Chhabra, S. R., Pritchard, D., & Shaw, P. E. (2004) · Oncogene · doi:10.1038/sj.onc.1207612 · Cited by 137 · see citing works
Pappas, K. M., & Winans, S. C. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03488.x · Cited by 111 · see citing works
Li, P., & Farrand, S. K. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.1.179-188.2000 · Cited by 109 · see citing works
Molina, L., Rezzonico, F., Défago, G., et al. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.9.3206-3213.2005 · Cited by 72 · see citing works
Scott, R. A., Weil, J., Le, P. T., et al. (2006) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-19-0227 · Cited by 58 · see citing works
Societal interactions in ovarian cancer metastasis: a quorum-sensing hypothesis
Hickson, J. A., Yamada, S. D., Berger, J., Alverdy, J. C., O’Keefe, J., Bassler, B. L., & Rinker-Schaeffer, C. W. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9177-z · Cited by 54 · see citing works
Regulation of Long-Chain N -Acyl-Homoserine Lactones in Agrobacterium vitis
Hao, G., & Bürr, T. J. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.6.2173-2183.2006 · Cited by 42 · see citing works
Lithgow, J. K., Danino, V., Jones, J. D. G., et al. (2002) · Springer eBooks · doi:10.1007/978-94-010-0566-1_1 · Cited by 29 · see citing works
Cui, X., & Harling, R. (2005) · European Journal of Plant Pathology · doi:10.1007/s10658-004-4891-0 · Cited by 26 · see citing works
Lithgow, J. K., Danino, V., Jones, J. D. G., et al. (2001) · Plant and Soil · doi:10.1023/a:1010333716277 · Cited by 26 · see citing works
Quorum Sensing in Bacteria-Plant Interactions
Braeken, K., Daniels, R., Ndayizeye, M., et al. (2008) · Soil biology · doi:10.1007/978-3-540-75575-3_11 · Cited by 24 · see citing works
Li, Y., Gronquist, M. R., Hao, G., et al. (2005) · Physiological and Molecular Plant Pathology · doi:10.1016/j.pmpp.2006.04.002 · Cited by 14 · see citing works
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Effect of essential oils on pathogenic bacteria
Nazzaro, F., Fratianni, F., De Martino, L., Coppola, R., & De Feo, V. (2013) · Pharmaceuticals · doi:10.3390/ph6121451 · Cited by 2,186 · see citing works
“The EOs of lavender, roses, geraniums, cloves and rosemary are also able to inhibit QS, whereas orange and juniper EOs appear to have no anti-QS properties [126–131].”
BackgroundSwamy, M. K., Akhtar, M. S., & Sinniah, U. R. (2016) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2016/3012462 · Cited by 949 · see citing works
Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems
Sharifi-Rad, J., Sureda, A., Tenore, G., Daglia, M., Sharifi-Rad, M., Valussi, M., Tundis, R., Sharifi-Rad, M., Loizzo, M., Ademiluyi, A., et al. (2017) · Molecules · doi:10.3390/molecules22010070 · Cited by 889 · see citing works
Essential Oils, A New Horizon in Combating Bacterial Antibiotic Resistance
Yap, P. S. X., Yiap, B. C., Ping, H. C., & Lim, S. H. E. (2014) · The Open Microbiology Journal · doi:10.2174/1874285801408010006 · Cited by 426 · see citing works
Quorum Sensing in the Context of Food Microbiology
Skandamis, P. N., & Nychas, G.-J. E. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.00468-12 · Cited by 215 · see citing works
- Authors
- Szabó, M. Á., Varga, G. Z., Hohmann, J., Schelz, Z., Szegedi, E., Amaral, L., & Molnár, J.
- Affiliations
- University of Szeged (HU)
- Corvinus University of Budapest (HU)
- University of Lisbon (PT)
- Corresponding author
- Molnár, József
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2009-10-13
- Volume
- 24
- Issue
- 5
- Pages
- 782-786
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2115712578
- Cited by
- 155
- References
- 29
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 3 · 2023: 4 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 15 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 8
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- quorum sensing inhibition, essential oils, N-acyl homoserine lactones, Chromobacterium violaceum CV026, Escherichia coli, biofilm formation, bacterial virulence, antibiotic resistance, rose oil, geranium oil, lavender essential oil, rosemary essential oil, eucalyptus oil, citrus essential oils, chamomile essential oil, juniper oil, orange oil
- MeSH terms
- Anti-Bacterial Agents, Chromobacterium, Escherichia coli, Oils, Volatile, Plant Oils, Magnoliopsida, Rosmarinus, Quorum Sensing, Acyl-Butyrolactones
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