Time to blood culture positivity as a marker for catheter-related candidemia
Open accessAbstract
Candida spp. are important causes of nosocomial bloodstream infections. Around 80% of patients with candidemia have an indwelling central venous catheter (CVC). Determining whether the CVC is the source of candidemia has implications for patient management. We assessed whether the time to detection of Candida species in peripheral blood (time to positivity [TTP]) can serve as a marker for catheter-related candidemia. Prospective surveillance of Candida bloodstream infection was conducted in two medical centers. TTP was recorded by the BacT/Alert automated system. Sixty-four candidemia episodes were included. Fifty patients (78%) had an indwelling CVC. Thirteen patients (20.3%) had definite catheter-related candidemia. TTP was shorter for definite catheter-related candidemia (17.3 ± 2 h) than that for candidemia from other sources (38.2 ± 3 h; P < 0.001). A TTP cutoff of 30 h was 100% sensitive and 51.4% specific for catheter-related candidemia (area under the receiver-operator characteristic curve of 0.76). We conclude that TTP in peripheral blood is a sensitive but nonspecific marker for catheter-related candidemia and that a TTP of more than 30 h can help exclude an intravascular catheter as the possible source of candidemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Detection of candidemia by blood culture often takes more than 24 hours, and for species such as Candida glabrata the time to positive culture can be even longer.
“Furthermore, detection of candidemia by blood culture often takes more than 24 hours.For certain species, such as C glabrata, the time to positive culture can be even longer.[56][57][58][59][60]”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [57]
Candida glabrata can take longer to grow in blood culture than other Candida species.
“Because growth can take even longer for C glabrata,10 more early infections may have been classified as late infections.”
From Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections (2010) · cites this paper as [10]
The average time for a positive blood culture across sites of infection has been reported to be 33.9 ± 3 hours.
“However, the average time for a positive culture across sites of infection has been reported to be 33.9 ± 3 hours, within our 2-day window.10”
From Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections (2010) · cites this paper as [10]
Because Candida glabrata can take longer to grow in culture, more early C glabrata infections may have been classified as late infections.
“Because growth can take even longer for C glabrata,10 more early infections may have been classified as late infections.”
From Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections (2010) · cites this paper as [10]
Peripheral blood time to positivity greater than 30 h is associated with a significantly lower likelihood of CVC infection; for the slow growing C. glabrata, a breakpoint of 48 h may be used.
“Peripheral blood time to positivity alone may also be of value, as a value greater than 30 h is associated with a significantly lower likelihood of CVC infection [100]. For the slow growing C. glabrata, a breakpoint of 48 h may be used [101].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P., & Edmond, M. B. (2004) · Clinical Infectious Diseases · doi:10.1086/421946 · Cited by 4,496 · see citing works
A Semiquantitative Culture Method for Identifying Intravenous-Catheter-Related Infection
Maki, D. G., Weise, C. E., & Sarafin, H. W. (1977) · New England Journal of Medicine · doi:10.1056/nejm197706092962301 · Cited by 2,052 · see citing works
Guidelines for the management of intravascular catheter-related infections
Mermel, L. A., Farr, B. M., Sherertz, R. J., Raad, I. I., O'Grady, N., Harris, J. S., & Craven, D. E. (2001) · Clinical Infectious Diseases · doi:10.1086/320001 · Cited by 1,449 · see citing works
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440 · see citing works
Attributable Mortality of Nosocomial Candidemia, Revisited
Gudlaugsson, O., Gillespie, S., Lee, K., Berg, J. V., Hu, J., Messer, S., Herwaldt, L., Pfaller, M., & Diekema, D. (2003) · Clinical Infectious Diseases · doi:10.1086/378745 · Cited by 1,140 · see citing works
Nosocomial Infections in Combined Medical-Surgical Intensive Care Units in the United States
Richards, M. J., Edwards, J. R., Culver, D. H., Gaynes, R. P., & System, N. N. I. S. (2000) · Infection Control and Hospital Epidemiology · doi:10.1086/501795 · Cited by 1,028 · see citing works
Zaoutis, T. E., Argon, J., Chu, J., Berlin, J. A., Walsh, T. J., & Feudtner, C. (2005) · Clinical Infectious Diseases · doi:10.1086/496922 · Cited by 784 · see citing works
Blumberg, H. M., Jarvis, W. R., Soucie, J. M., Edwards, J. E., Patterson, J. E., Pfaller, M. A., Rangel‐Frausto, M. S., Rinaldi, M. G., Saiman, L., Wiblin, R. T., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/321811 · Cited by 661 · see citing works
Epidemiology of Nosocomial Fungal Infections, with Emphasis on Candida Species
Jarvis, W. R. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.6.1526 · Cited by 636 · see citing works
Blot, F., Nitenberg, G., Chachatty, E., Raynard, B., Germann, N., Antoun, S., Laplanche, A., Brun‐Buisson, C., & Tancrède, C. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11134-0 · Cited by 434 · see citing works
Specific Gravity of Blood and Plasma at 4 and 37 °C
TRUDNOWSKI, R. J., & Rico, R. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.5.615 · Cited by 211 · see citing works
Quantitative blood cultures in the evaluation of septicemia in children with Broviac catheters
Raucher, H. S., Hyatt, A. C., Barzilai, A., Harris, M. B., Weiner, M. A., LeLeiko, N. S., & Hodes, D. S. (1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)80584-3 · Cited by 153 · see citing works
Khatib, R., RIEDERER, K. M., Saeed, S., Johnson, L. B., Fakih, M. G., Sharma, M., Tabriz, M. S., & Khosrovaneh, A. (2005) · Clinical Infectious Diseases · doi:10.1086/432472 · Cited by 151 · see citing works
Use of Quantitative Bacteriologic Techniques to Diagnose Catheter-Related Sepsis
Wing, E. J. (1979) · Archives of Internal Medicine · doi:10.1001/archinte.1979.03630410086026 · Cited by 130 · see citing works
Marra, A. R., Edmond, M. B., Forbes, B. A., Wenzel, R. P., & Bearman, G. M. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.4.1342-1346.2006 · Cited by 130 · see citing works
Billé, J., Edson, R. S., & Roberts, G. D. (1984) · Journal of Clinical Microbiology · doi:10.1128/jcm.19.2.126-128.1984 · Cited by 94 · see citing works
Horvath, L. L., Hospenthal, D. R., Murray, C. K., & Dooley, D. P. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.10.4714-4717.2003 · Cited by 71 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ESCMID∗ guideline for the diagnosis and treatment of biofilm infections 2014
Høiby, N., Bjarnsholt, T., Moser, C. E., Bassi, G. L., Coenye, T., Donelli, G., Hall‐Stoodley, L., Holá, V., Imbert, C., Kirketerp‐Møller, K., et al. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2014.10.024 · Cited by 801 · see citing works
Bassetti, M., Azoulay, É., Kullberg, B. J., Ruhnke, M., Shoham, S., Vázquez, J. A., Giacobbe, D. R., & Calandra, T. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1751 · Cited by 339 · see citing works
Lebeaux, D., Fernández‐Hidalgo, N., Chauhan, A., Lee, S. J., Ghigo, J., Almirante, B., & Beloin, C. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70266-4 · Cited by 193 · see citing works
Marcos-Zambrano, L. J., Escribano, P., Bouza, E., & Guinea, J. (2014) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2014.08.012 · Cited by 161 · see citing works
Ruhnke, M., Rickerts, V., Cornely, O. A., Buchheidt, D., Glöckner, A., Heinz, W., Höhl, R., Horré, R., Karthaus, M., Kujath, P., et al. (2011) · Mycoses · doi:10.1111/j.1439-0507.2011.02040.x · Cited by 137 · see citing works
Effect of antifungal therapy timing on mortality in cancer patients with candidemia
Taur, Y., Cohen, N., Dubnow, S., Paskovaty, A., & Seo, S. K. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00945-09 · Cited by 127 · see citing works
Treatment of Invasive Candidiasis: A Narrative Review
Ben-Ami, R. (2018) · Journal of Fungi · doi:10.3390/jof4030097 · Cited by 111 · see citing works
Self-citationMoran, C., Grussemeyer, C. A., Spalding, J. R., Benjamin, D. K., & Reed, S. D. (2010) · American Journal of Infection Control · doi:10.1016/j.ajic.2009.06.014 · Cited by 91 · see citing works
Invasive fungal infections in patients with cancer in the Intensive Care Unit
Sipsas, N. V., & Kontoyiannis, D. P. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2011.11.017 · Cited by 80 · see citing works
Time to positivity of blood cultures of different Candida species causing fungaemia
Lai, C., Wang, C.-Y., Liu, W., Huang, Y., & Hsueh, P. (2012) · Journal of Medical Microbiology · doi:10.1099/jmm.0.038166-0 · Cited by 75 · see citing works
Mini-review: Antimicrobial central venous catheters – recent advances and strategies
Sousa, C., Henriques, M., & Oliveira, R. (2011) · Biofouling · doi:10.1080/08927014.2011.593261 · Cited by 70 · see citing works
Clinical impact of time to positivity for Candida species on mortality in patients with candidaemia
Kim, S., Yoon, Y. K., Kim, M. J., & Sohn, J. W. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt256 · Cited by 69 · see citing works
The role of antifungals against Candida biofilm in catheter-related candidemia
Bouza, E., Guinea, J., & Guembe, M. (2014) · Antibiotics · doi:10.3390/antibiotics4010001 · Cited by 62 · see citing works
Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting
Lepak, A., & Andes, D. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2010.11.001 · Cited by 62 · see citing works
Ding, L., Xia, R., Zhang, Q., Bai, C., Li, Z., & Zhang, P. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2636-x · Cited by 60 · see citing works
Can microbiologists help to assess catheter involvement in candidaemic patients before removal?
Bouza, E., groups, O. B. O. T. G. A. T. C. S., Alcalá, L., Muñóz, P., Martín‐Rabadán, P., Guembe, M., & Rodríguez‐Créixems, M. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12096 · Cited by 57 · see citing works
Time to positivity of blood culture and its prognostic value in bloodstream infection
Ning, Y., Hu, R., Yao, G., & Bo, S. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2580-5 · Cited by 54 · see citing works
Role of Exopolysaccharides in Biofilm Formation
Gupta, P., Pruthi, P. A., & Pruthi, V. (2019) · ACS symposium series · doi:10.1021/bk-2019-1323.ch002 · Cited by 53 · see citing works
CandidaBloodstream Infections in Italy: Changing Epidemiology during 16 Years of Surveillance
Caggiano, G., Coretti, C., Bartolomeo, N., Lovero, G., Giglio, O. D., & Montagna, M. T. (2015) · BioMed Research International · doi:10.1155/2015/256580 · Cited by 50 · see citing works
Candidemia: species involved, virulence factors and antimycotic susceptibility.
Luca, C. D., Guglielminetti, M. L., Ferrario, A., Calabr, M., & Casari, E. (2012) · PubMed · Cited by 49 · see citing works
Diagnostic Usefulness of Differential Time to Positivity for Catheter-Related Candidemia
Park, K., Lee, M. S., Lee, S., Choi, S., Sung, H., Kim, M., Kim, Y. S., Woo, J. H., & Kim, S. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.00605-14 · Cited by 48 · see citing works
Eliakim‐Raz, N., Babaoff, R., Yahav, D., Yanai, S., Shaked, H., & Bishara, J. (2016) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2016.09.018 · Cited by 46 · see citing works
Smith, D. F. Q., & Casadevall, A. (2021) · Pathogens and Disease · doi:10.1093/femspd/ftab013 · Cited by 47 · see citing works
Playford, E. G., Eggimann, P., & Calandra, T. (2008) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3283177967 · Cited by 42 · see citing works
An Italian consensus for invasive candidiasis management (ITALIC)
Scudeller, L., Viscoli, C., Menichetti, F., Bono, V. D., Cristini, F., Tascini, C., Bassetti, M., & Viale, P. (2013) · Infection · doi:10.1007/s15010-013-0558-0 · Cited by 41 · see citing works
Nunes, C. Z., Marra, A. R., Edmond, M. B., Victor, E. D. S., & Pereira, C. A. P. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-486 · Cited by 38 · see citing works
Persistent Candidemia: Causes and Investigations
Nucci, M. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0039-1 · Cited by 36 · see citing works
Huang, L., Zhang, Y. Y., & Sun, L. (2013) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-1826-8 · Cited by 36 · see citing works
Lin, S., Chen, R., Zhu, S., Wang, H., Wang, L., Zou, J., Yan, J., Zhang, X., Farmakiotis, D., Tan, X., et al. (2018) · Mycopathologia · doi:10.1007/s11046-018-0258-5 · Cited by 30 · see citing works
Management of Invasive Candidiasis in the Intensive Care Unit
Playford, E. G., Lipman, J., & Sorrell, T. C. (2010) · Drugs · doi:10.2165/10898550-000000000-00000 · Cited by 29 · see citing works
Coping with Candida Infections
Evans, S. E. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200907-075al · Cited by 27 · see citing works
Invasive Candidiasis: Epidemiology and Risk Factors
Cortés, J. A., & Corrales, I. F. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81813 · Cited by 28 · see citing works
Kwon, Y. J., Won, E. J., Jeong, S. H., Shin, K. S., Shin, J. H., Kim, Y. R., Kim, Y. R., Kim, H. S., Kim, Y. A., Kim, T. S., et al. (2021) · Journal of Fungi · doi:10.3390/jof7080597 · Cited by 29 · see citing works
Kontoyiannis, D. P., & Patterson, T. F. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu591 · Cited by 27 · see citing works
Hu, B., Du, Z., Kang, Y., Zang, B., Cui, W., Qin, B., Fang, Q., Qiu, H., & Li, J. (2014) · BMC Infectious Diseases · doi:10.1186/s12879-014-0594-0 · Cited by 26 · see citing works
Associated clinical characteristics of patients with candidemia among different Candida species
Chen, L.-Y., Kuo, S., Wu, H.-S., Yang, S.-P., Chan, Y., Chen, L., & Wang, F. (2012) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2012.08.001 · Cited by 25 · see citing works
Darouiche, R. O. (2009) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2009.02.013 · Cited by 23 · see citing works
Iatta, R., Caggiano, G., Cuna, T., & Montagna, T. (2011) · Journal of Chemotherapy · doi:10.1179/joc.2011.23.2.92 · Cited by 23 · see citing works
Guembe, M., Martín‐Rabadán, P., Echenagusía, A., Camúñez, F., Rodríguez-Rosales, G., Simó, G., Echenagusia, M. A., & Bouza, E. (2013) · Journal of Clinical Microbiology · doi:10.1128/jcm.01351-13 · Cited by 22 · see citing works
Candida utilis catheter-related bloodstream infection
Scoppettuolo, G., Donato, C., Carolis, E. D., Vella, A., Vaccaro, L., Greca, A. L., & Fantoni, M. (2014) · Medical Mycology Case Reports · doi:10.1016/j.mmcr.2014.10.003 · Cited by 22 · see citing works
Is Biofilm Production a Predictor of Catheter-Related Candidemia?
Guembe, M., Guinea, J., Marcos-Zambrano, L. J., Fernández‐Cruz, A., Peláez, T., Munoz, P., & Bouza, E. (2014) · Medical Mycology · doi:10.1093/mmy/myt031 · Cited by 20 · see citing works
Tiraboschi, I. N., Pozzi, N. C., Farías, L., García, S., & Fernández, N. (2017) · Revista chilena de infectología · doi:10.4067/s0716-10182017000500431 · Cited by 20 · see citing works
Miyazaki, T., & Kohno, S. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2015.1058157 · Cited by 18 · see citing works
Cobos-Trigueros, N., Morata, L., Torres, J. L., Zboromyrska, Y., Soriano, À., Pitart, C., Calle, C. D. L., Marco, F., Hernandez, C., Almela, M., et al. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt285 · Cited by 17 · see citing works
Nanotechnology applied to medical biofilms control
Sousa, C., Botelho, C., & Oliveira, R. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 15 · see citing works
Yeast as a Model for Ras Signalling
Tisi, R., Belotti, F., & Martegani, E. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-791-4_23 · Cited by 14 · see citing works
Is it feasible to diagnose catheter-related candidemia without catheter withdrawal?
Fernández‐Cruz, A., Martín‐Rabadán, P., Suárez-Salas, M., Rojas-Wettig, L., Pérez-Granda, M. J., Guinea, J., Guembe, M., Pelaez, T., Sánchez‐Carrillo, C., Bouza, E., et al. (2014) · Medical Mycology · doi:10.1093/mmy/myu013 · Cited by 13 · see citing works
Gits‐Muselli, M., Villiers, S., Hamane, S., Berçot, B., Donay, J., Denis, B., Guigue, N., Alanio, A., & Bretagne, S. (2019) · Mycoses · doi:10.1111/myc.13024 · Cited by 13 · see citing works
Elvy, J. A., Walker, D. A., Haremza, E., Ryan, K., & Morris, A. J. (2020) · Pathology · doi:10.1016/j.pathol.2020.09.020 · Cited by 10 · see citing works
Managing intravascular catheter-related infections in heart transplant patients
Bouza, E., Burillo, A., & Guembe, M. (2011) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328348b1b9 · Cited by 10 · see citing works
Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013
Sin, L., Legarraga, P., García, P., González, T. C., & Ricardo Rabagliati, B. (2017) · Revista chilena de infectología · doi:10.4067/s0716-10182017000100003 · Cited by 10 · see citing works
Unresolved issues in the diagnosis of catheter related candidemia: A position paper
Soriano-Martín, A., Muñóz, P., García‐Rodríguez, J., Cantón, R., Vena, A., Bassetti, M., & Bouza, E. (2023) · Revista Española de Quimioterapia · doi:10.37201/req/112.2023 · Cited by 9 · see citing works
Update: invasive Pilzinfektionen: Diagnose und Therapie in der operativen Intensivmedizin
Lichtenstern, C., Swoboda, S., Hirschburger, M., Domann, E., Hoppe‐Tichy, T., Winkler, M., Lass‐Flörl, C., & Weigand, M. A. (2010) · Der Anaesthesist · Cited by 9 · see citing works
Update: invasive Pilzinfektionen
Lichtenstern, C., Swoboda, S., Hirschburger, M., Domann, E., Hoppe‐Tichy, T., Winkler, M., Lass‐Flörl, C., & Weigand, M. A. (2010) · Der Anaesthesist · doi:10.1007/s00101-009-1655-4 · Cited by 10 · see citing works
Rixecker, T. M., Lesan, V., Ahlgrimm, M., Thurner, L., Bewarder, M., Murawski, N., Christofyllakis, K., Altmeyer, S., Bick, A., Stilgenbauer, S., et al. (2020) · Bone Marrow Transplantation · doi:10.1038/s41409-020-01003-0 · Cited by 8 · see citing works
Martinez, R. M., Bowen, T. R., & Foltzer, M. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.dmih2-0004-2015 · Cited by 8 · see citing works
Stempel, J. M., Farmakiotis, D., Tarrand, J. J., & Kontoyiannis, D. P. (2016) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2016.04.001 · Cited by 7 · see citing works
Clinical significance of time to positivity for yeast in candidemia
Chen, L.-Y., Yang, S.-P., Chen, T.-L., Liao, S.-Y., Chen, Y.-Y., Chan, Y., Chen, L., & Wang, F. (2014) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2013.11.002 · Cited by 7 · see citing works
Review of techniques for diagnosis of catheter-related Candida biofilm infections
Nett, J. E., & Andes, D. R. (2008) · Current Fungal Infection Reports · doi:10.1007/s12281-008-0035-x · Cited by 6 · see citing works
Deep-seated Candida infections in the intensive care unit
Brusselaers, N., Blot, S. I., & Vogelaers, D. (2011) · Ghent University Academic Bibliography (Ghent University) · Cited by 6 · see citing works
Li, J., Li, Y., Gao, Y., Niu, X., Tang, M., Fu, C., Wang, Z., Liu, J., Song, B., Chen, H., et al. (2022) · BioMed Research International · doi:10.1155/2022/7896218 · Cited by 5 · see citing works
RetractedTime to positivity of blood cultures causing candidemia and its relation to mortality
Sachu, A., Sunny, S., Mathew, P., Kumar, A., & David, A. (2024) · Iranian Journal of Microbiology · doi:10.18502/ijm.v16i2.15361 · Cited by 5 · see citing works
Fluconazole-Resistant Candida : Collateral Damage Associated with Prior Antibacterial Exposure?
Ben‐Ami, R., & Giladi, M. (2012) · Future Microbiology · doi:10.2217/fmb.12.83 · Cited by 5 · see citing works
Self-citationTime-to-Positivity for Candida in Bloodstream Infections: Prognostic Implications for Mortality
Balaji, L., Manoharan, H., Prabhakaran, N., & Nandhagopal, M. (2024) · Cureus · doi:10.7759/cureus.66364 · Cited by 4 · see citing works
Early diagnosis of blood culture isolates in patients with candidemia using PNA FISH
Forrest, G. N. (2008) · Current Fungal Infection Reports · doi:10.1007/s12281-008-0032-0 · Cited by 4 · see citing works
Invasive Candidiasis in the Neutropenic Cancer Patient
Gamaletsou, M. N., Sipsas, N. V., & Kontoyiannis, D. P. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0044-4 · Cited by 4 · see citing works
Invasive Candidiasis in Patients with Implants
Shoham, S. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0040-8 · Cited by 4 · see citing works
Butta, H., Sardana, R., Mendiratta, L., Sibal, A., Gupta, V., Chawla, R., & Jafri, A. A. (2019) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-23108 · Cited by 5 · see citing works
Chiueh, T., Lee, S.-Y., Tang, S., Lu, J., & Sun, J. (2013) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21571 · Cited by 3 · see citing works
Fungal Infections in Cancer Patients
Granwehr, B. P., & Kontoyiannis, D. P. (2021) · Springer eBooks · doi:10.1007/978-3-319-74698-2_121-2 · Cited by 3 · see citing works
Martinez, R. M., Bowen, T. R., & Foltzer, M. A. (2016) · ASM Press eBooks · doi:10.1128/9781555819040.ch27 · Cited by 3 · see citing works
Clinical utility of time to positivity of blood cultures in cases of fungaemia: A prospective study
Kaur, H., Kanaujia, R., Singh, S., Kajal, K., Jayashree, M., Peter, N. J., Verma, S., Gupta, M., Ray, P., Ghosh, A. K., et al. (2022) · Indian Journal of Medical Microbiology · doi:10.1016/j.ijmmb.2022.08.014 · Cited by 3 · see citing works
Time to positivity as a diagnostic tool for catheter-related candidemia: A species-specific analysis
Albanell‐Fernández, M., Vergara, A., Cardozo, C., Herrera, S., Verdejo, M. Á., Malano-Barletta, D., Pitart, C., Hernández‐Meneses, M., Cuervo, G., García‐Vidal, C., et al. (2026) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2026.108847 · Cited by 2 · see citing works
Erratum to: An Italian consensus for invasive candidiasis management (ITALIC)
Scudeller, L., Viscoli, C., Menichetti, F., Bono, V. D., Cristini, F., Tascini, C., Bassetti, M., & Viale, P. (2014) · Infection · doi:10.1007/s15010-013-0577-x · Cited by 2 · see citing works
Gürcüoğlu, E., Çalışkan, G., Benli, M. T., & Timur, D. (2026) · Journal of Fungi · doi:10.3390/jof12080563 · Cited by 1 · see citing works
Utility of time to positivity for diagnosis of bloodstream infection
Ding, J.-Y., & Wang, P. (2011) · Reviews in Medical Microbiology · doi:10.1097/mrm.0b013e328342ceaa · Cited by 1 · see citing works
Faculté de Médecine, U. D. B. 2. –. A., Hamouda, O., Fendri, A. H., & –Algérie., F. D. M. C. (2021) · Batna Journal of Medical Sciences (BJMS) · doi:10.48087/bjmsoa.2021.8201 · Cited by 1 · see citing works
Fungal Infections in Cancer Patients
Granwehr, B. P., Sipsas, N. V., & Kontoyiannis, D. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-74588-6_121 · Cited by 1 · see citing works
Pathogens in Severe Sepsis: New Paradigms for Fungi Treatment
Bassetti, M., & Mikulska, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-03519-7_11
Innovative Strategies for Preventing Central-Line Associated Infections
Bouza, E., Guembe, M., & Pérez-Granda, M. J. (2013) · Current treatment options in infectious diseases/Current treatment options in infectious disease · doi:10.1007/s40506-013-0001-1
Update: invasive Pilzinfektionen Diagnose und Therapie in der operativen Intensivmedizin
Anaesthesiologie, K. F., Heidelberg, U., & Briegel, J. (2010)
Frequency of Catheter Related Blood Stream Infections in a Cardiac Surgery Intensive Care Unit
Fatima, A., Mehdi, N., & Aslam, N. (2020) · International Journal of Contemporary Medical Research [IJCMR] · doi:10.21276/ijcmr.2020.7.2.6
Pilzinfektionen in der Intensivmedizin
Richter, D., Lichtenstern, C., Brinkmann, A., & Weigand, M. A. (2020) · Intensivmedizin up2date · doi:10.1055/a-1067-2797
Pilzinfektionen in der Intensivmedizin
Richter, D., Lichtenstern, C., Brinkmann, A., & Weigand, M. A. (2021) · Krankenhaushygiene up2date · doi:10.1055/a-1338-9359
Fungal Infections in Cancer Patients
Granwehr, B. P., Sipsas, N. V., & Kontoyiannis, D. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-74698-2_121-1
Forrest, G. N., Mohammadi, J., & Mohammadi, S. (2015) · doi:10.1002/9783527687978.ch7
Evaluation of Positivity Times of Isolates Growing in Blood Cultures
Karpuz, T., Yazısız, H., Özyurt, Ö. K., Çetinkaya, Ö., Özhak, B., Öngüt, G., Çolak, D., & Öğünç, D. (2022) · Flora the Journal of Infectious Diseases and Clinical Microbiology · doi:10.5578/flora.20229805
Soriano-Martín, A., Vena, A., Pérez-Granda, M. J., Limongelli, A., Burillo, A., Escribano, P., Guinea, J., Mikulska, M., Giacobbe, D. R., Machado, M., et al. (2026) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofag411
Albanell‐Fernández, M., Vergara, A., & Soriano, Á. (2026) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2026.109031
- Authors
- Ben-Ami, R., Weinberger, M., Orni-Wasserlauff, R., Schwartz, D., Itzhaki, A., Lazarovitch, T., Bash, E., Aharoni, Y., Moroz, I., & Giladi, M.
- Affiliations
- Infectious Diseases Unit
- Tel Aviv University (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Assaf Harofeh Medical Center (IL)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2008-07
- Volume
- 46
- Issue
- 7
- Pages
- 2222-2226
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC2446879
- OpenAlex
- W2105581912
- Cited by
- 90
- References
- 18
- Citations by year
- 2026: 4 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 10 · 2012: 6
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Keywords
- catheter-related candidemia, time to positivity, blood culture, candidemia, central venous catheters, nosocomial infections, infection source identification, diagnostic biomarkers, BacT/Alert
- MeSH terms
- Academic Medical Centers, Aged, Aged, 80 and over, Blood, Candida, Candidiasis, Catheters, Indwelling, Cross Infection, Female, Humans, Male, Middle Aged, Mycology, Prospective Studies, Sensitivity and Specificity, Time Factors, Fungemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
