The role of antifungals against Candida biofilm in catheter-related candidemia

Bouza, Emilio; Guinea, Jesús; Guembe, María

doi:10.3390/antibiotics4010001

Cited by 62Antifungal resistance and susceptibilityInfective Endocarditis Diagnosis and ManagementCentral Venous Catheters and Hemodialysis

The role of antifungals against Candida biofilm in catheter-related candidemia

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Bouza, Emilio, Guinea, Jesús, Guembe, María·2014·Antibiotics

DOI 10.3390/antibiotics4010001PMC PMC4790322

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Abstract

Catheter-related bloodstream infection (C-RBSI) is one of the most frequent nosocomial infections. It is associated with high rates of morbidity and mortality. Candida spp. is the third most common cause of C-RBSI after coagulase-negative staphylococci and Staphylococcus aureus and is responsible for approximately 8% of episodes. The main cause of catheter-related candidemia is the ability of some Candida strains—mainly C. albicans and C. parapsilosis—to produce biofilms. Many in vitro and in vivo models have been designed to assess the activity of antifungal drugs against Candida biofilms. Echinocandins have proven to be the most active antifungal drugs. Potential options in situations where the catheter cannot be removed include the combination of systemic and lock antifungal therapy. However, well-designed and -executed clinical trials must be performed before firm recommendations can be issued.

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Other approaches under investigation for Candida biofilms include antimicrobial peptides, inhibitors of biofilm matrix components (e.g., extracellular DNA), probiotics, hsp90 inhibition, modulators of quorum sensing, photodynamic therapy, catheter locks, surface coatings, and inhibition of biofilm dispersal.
“These include the use antimicrobial peptides, inhibitors of other components within the biofilm matrix (i.e. extracellular DNA), the use of probiotics, hsp90 inhibition, as well as modulators of quorum sensing [[87], [88], [89], [90], [91], [92], [93]]. An interesting methodology being developed and applied to the Candida biofilm field is that of photodynamic therapy (PDT), where the inhibitory”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [99]

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[35]Lebeaux D.K.I. Decante B. Ghigo J. Beloin C. Plessis-Robinson L. Modelling of controlled biofilm infection using rats with totally implantable port access intravenous catheter Proceedings of the European Congress of Clinical Microbiology and Infectious Diseases Milan, Italy 7–10 May 2011 Abstract No. O187

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Authors: Bouza, E., Guinea, J., & Guembe, M.
Affiliations: Universidad Complutense de Madrid (ES)
Hospital General Universitario Gregorio Marañón (ES)
Corresponding author: Guembe, María
ORCID: Bouza, Emilio
Guinea, Jesús
Guembe, María
Venue: Antibiotics
Publisher: MDPI AG
Published: 2014-12-25
Volume: 4
Issue: 1
Pages: 1-17
ISSN: 2079-6382 (ISSN-L)
DOI: 10.3390/antibiotics4010001
PMC: PMC4790322
OpenAlex: W2017633020
Cited by: 62
References: 144
Citations by year: 2026: 5 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 1
FWCI: 0.14
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Antibiotics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
Keywords: catheter-related candidemia, Candida biofilms, antifungal agents, echinocandins, Candida albicans, Candida parapsilosis, catheter-related bloodstream infection, nosocomial infections, antifungal susceptibility testing

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The role of antifungals against Candida biofilm in catheter-related candidemia

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