Candida in the ICU

Darouiche, Rabih O.

doi:10.1016/j.ccm.2009.02.013

Cited by 23Antifungal resistance and susceptibilityNosocomial Infections in ICUInfective Endocarditis Diagnosis and Management

Candida in the ICU

Darouiche, Rabih O.·2009·Clinics in Chest Medicine

DOI 10.1016/j.ccm.2009.02.013

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Abstract

Invasive Candida infections are becoming increasingly recognized in critically ill patients. These infections result in serious morbidity, can be life threatening, and are expensive to manage. Early suspicion of Candida infection and the use of timely and proper antifungal treatment can improve outcome. Although treatment of documented, deep-seated Candida infections in nonneutropenic patients has been studied extensively, guidelines for the management of suspected but undocumented cases of invasive Candida infections in critically ill patients have not been clearly established. Future work should focus on better delineation of the sector of critically ill patients who have suspected invasive Candida infection and who could benefit from the use of empiric antifungal therapy, and on the investigation of novel approaches for the potential salvage of devices infected with Candida species.

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The gold standard diagnostic test for invasive candidiasis has been isolation of the organism in blood culture, but blood culture for Candida is insensitive.
“In addition, the gold standard diagnostic test for IC has been isolation of the organism in blood culture, however, blood culture for Candida is insensitive.[52][53][54][55]”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [52]

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Authors: Darouiche, R. O.
Affiliations: Michael E. DeBakey VA Medical Center (US)
Corresponding author: Darouiche, Rabih O.
Venue: Clinics in Chest Medicine
Publisher: Elsevier BV
Published: 2009-06
Volume: 30
Issue: 2
Pages: 287-293
ISSN: 0272-5231 (ISSN-L)
DOI: 10.1016/j.ccm.2009.02.013
OpenAlex: W2033907180
Cited by: 23
References: 42
Citations by year: 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2012: 3
FWCI: 0.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinics in Chest Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
Keywords: invasive candidiasis, Candida, critically ill patients, intensive care unit, empirical antifungal therapy, antifungal therapy, Candida colonization
MeSH terms: Candidiasis, Humans, Intensive Care Units, Critical Illness

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Candida in the ICU

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