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Cited by 145Tuberculosis Research and EpidemiologyDiagnosis and treatment of tuberculosisInfectious Diseases and Tuberculosis

Comparison of Two Molecular Methods for Rapid Diagnosis of Extrapulmonary Tuberculosis

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Causse, Manuel, Ruiz, Pilar, Gutiérrez-Aroca, Juan Bautista, Casal, Manuel·2011·Journal of Clinical Microbiology
DOI 10.1128/jcm.00491-11PMC PMC3147762
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Abstract

Application of real-time PCR for the detection of Mycobacterium tuberculosis enables results to be obtained in about 2 h. A total of 340 nonrespiratory samples were processed using two real-time PCR assay kits: Xpert MTB/RIF and Cobas TaqMan MTB. The sensitivity and specificity of the Xpert assay were 95% and 100%, respectively, compared to 78% and 98% for the Cobas assay.

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  • 13 studies (839 samples; 10 with >10 samples, 159 culture positive) evaluated Xpert in CSF against culture.

    “13 studies (839 samples; 10 with .10samples, 159 culture positive) evaluated Xpert in CSF against culture [14-16, 19, 20, 22-25, 27-29, 31].”

    From Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: a systematic review and meta-analysis (2014) · cites this paper as [16]

  • FNA is increasingly being used worldwide as a first diagnostic step because of its ease and safety profile, although sensitivity is very variable depending on the study, with positive mycobacterial culture ranging from 10% to 80%.

    “FNA is increasingly being used worldwide as a first diagnostic step because of its ease and safety profile, although sensitivity is very variable depending on the study, with positive mycobacterial culture ranging from 10% to 80%.3,4,13–16”

    From Epidemiology and Diagnosis of Tuberculous Lymphadenitis in a Tuberculosis Low-Burden Country (2015) · cites this paper as [15]

    The methods (p. 1) describe extrapulmonary samples and compare two molecular assays against culture; the results (p. 2) report assay performance. Our copy does not discuss FNA as a first diagnostic step, its ease or safety, or a 10%–80% range of positive mycobacterial cultures (searched: FNA, fine-needle aspiration, and the stated range). (LLM, conf=0.76)

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Authors
Causse, M., Ruiz, P., Gutiérrez-Aroca, J. B., & Casal, M.
Affiliations
  • Hospital Universitario Reina Sofía (ES)
  • University of Córdoba (ES)
ORCID
Venue
Journal of Clinical Microbiology
Publisher
American Society for Microbiology
Published
2011-08
Volume
49
Issue
8
Pages
3065-3067
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
DOI
10.1128/jcm.00491-11
PMC
PMC3147762
OpenAlex
W2135290191
Semantic Scholar
c1f0f61431f4e037c237ffcb6ced774fc51958b0
Cited by
145
References
14
Citations by year
2024: 4 · 2023: 5 · 2022: 2 · 2021: 15 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 5 · 2015: 19 · 2014: 20 · 2013: 21 · 2012: 16
FWCI
13.59
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Clinical Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
  • Universidad de Córdoba Insitutional Repository (Universidad de Córdoba) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords
extrapulmonary tuberculosis, Mycobacterium tuberculosis detection, real-time PCR, Xpert MTB/RIF, sensitivity and specificity, rapid molecular diagnostics
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Bacteriological Techniques, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Mycobacterium tuberculosis, Sensitivity and Specificity, Tuberculosis, Molecular Diagnostic Techniques, Young Adult

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