Missing Cases of Herpes Simplex Virus (HSV) Infection of the Central Nervous System When the Reller Criteria Are Applied for HSV PCR Testing: a Multicenter Study

Albert, Eliseo; Alberola, Juan; Bosque, Monserrat; Camarena, Juan José; Clari, María Ángeles; Domínguez Márquez, María Victoria; Gil-Fortuño, María; Gimeno, Adelina; Nogueira, José Miguel; Ocete, María Dolores; Orta, Nieves; Prat, Josep; Rodríguez, Juan Carlos; Valero, Isabel; Gimeno Cardona, Concepción; Navarro, David

doi:10.1128/jcm.01719-18

Missing Cases of Herpes Simplex Virus (HSV) Infection of the Central Nervous System When the Reller Criteria Are Applied for HSV PCR Testing: a Multicenter Study

Previous studies suggested that herpes simplex virus (HSV) PCR testing can be safely deferred in patients with normal cerebrospinal fluid (CSF) white blood cell (WBC) counts and protein levels as long as they are older than 2 years of age and are not immunocompromised, the so-called Reller criter…