Cited by 554Viral gastroenteritis research and epidemiologyBacterial Identification and Susceptibility TestingSalmonella and Campylobacter epidemiology

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Multicenter Evaluation of the BioFire FilmArray Gastrointestinal Panel for Etiologic Diagnosis of Infectious Gastroenteritis

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Buss, Sarah N., Leber, Amy, Chapin, Kimberle, Fey, Paul D., Bankowski, Matthew J., Jones, Matthew K., Rogatcheva, Margarita, Kanack, Kristen J., Bourzac, Kevin M.·2015·Journal of Clinical Microbiology

DOI 10.1128/jcm.02674-14PMC PMC4390666

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Abstract

The appropriate treatment and control of infectious gastroenteritis depend on the ability to rapidly detect the wide range of etiologic agents associated with the disease. Clinical laboratories currently utilize an array of different methodologies to test for bacterial, parasitic, and viral causes of gastroenteritis, a strategy that suffers from poor sensitivity, potentially long turnaround times, and complicated ordering practices and workflows. Additionally, there are limited or no testing methods routinely available for most diarrheagenic Escherichia coli strains, astroviruses, and sapoviruses. This study assessed the performance of the FilmArray Gastrointestinal (GI) Panel for the simultaneous detection of 22 different enteric pathogens directly from stool specimens: Campylobacter spp., Clostridium difficile (toxin A/B), Plesiomonas shigelloides , Salmonella spp., Vibrio spp., Vibrio cholerae , Yersinia enterocolitica , enteroaggregative E. coli , enteropathogenic E. coli , enterotoxigenic E. coli , Shiga-like toxin-producing E. coli ( stx 1 and stx 2 ) (including specific detection of E. coli O157), Shigella spp./enteroinvasive E. coli , Cryptosporidium spp., Cyclospora cayetanensis , Entamoeba histolytica , Giardia lamblia , adenovirus F 40/41, astrovirus, norovirus GI/GII, rotavirus A, and sapovirus. Prospectively collected stool specimens ( n = 1,556) were evaluated using the BioFire FilmArray GI Panel and tested with conventional stool culture and molecular methods for comparison. The FilmArray GI Panel sensitivity was 100% for 12/22 targets and ≥94.5% for an additional 7/22 targets. For the remaining three targets, sensitivity could not be calculated due to the low prevalences in this study. The FilmArray GI Panel specificity was ≥97.1% for all panel targets. The FilmArray GI Panel provides a comprehensive, rapid, and streamlined alternative to conventional methods for the etiologic diagnosis of infectious gastroenteritis in the laboratory setting. The potential advantages include improved performance parameters, a more extensive menu of pathogens, and a turnaround time of as short as 1 h.

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Items 101–200 of 471

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Method
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“Similarly, clinical laboratories in other parts of the USA have previously reported that 78–84% of ETEC-positive specimens were also positive for at least one other pathogen [12, 14].”
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Clinical evaluation of the BioFire FilmArray ® BioThreat-E test for the diagnosis of Ebola Virus Disease in Guinea
Gay‐Andrieu, F., Magassouba, N., Picot, V., Phillips, C. L., Peyrefitte, C. N., Dacosta, B., Doré, A., Kourouma, F., Ligeon, V., Gauby, C., et al. (2017) · Journal of Clinical Virology · doi:10.1016/j.jcv.2017.04.015 · Cited by 30
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“than that of culturing has been reported [18].”
Background
Quality Improvements in Management of Children with Acute Diarrhea Using a Multiplex-PCR-Based Gastrointestinal Pathogen Panel
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“r t ti l t l t i , t ioFire GI Panel rapidly and accurately t t i r f ir , t ri arasites that can cause AGE [19, 2,23].”
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Comparison of several Real-Time PCR Kits versus a Culture-dependent Algorithm to Identify Enteropathogens in Stool Samples
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“Modern tools, such as the BioFire FilmArray Gastrointestinal Panel [11], are now utilized for pathogen identification.”
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“These results are similar to those reported by the multicenter clinical trial for the FilmArray gastrointestinal panel (13).”
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Background
Epidemiology and Economic Burden of Acute Infectious Gastroenteritis Among Adults Treated in Outpatient Settings in US Health Systems
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“histolytica using fully automated PCR systems (61-66).”
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Method
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Ramakrishnan, B., Gopalakrishnan, R., Nambi, P. S., Durairajan, S., Madhumitha, R., Tarigopula, A., Chandran, C., & Ramasubramanian, V. (2018) · Indian Journal of Gastroenterology · doi:10.1007/s12664-018-0889-y · Cited by 20
Higher atypical enteropathogenic Escherichia coli (a-EPEC) bacterial loads in children with diarrhea are associated with PCR detection of the EHEC factor for adherence 1/lymphocyte inhibitory factor A (efa1/lifa) gene
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“Of note, work to clarify the pathogenicity of a-EPEC has become more crucial in recent years since EPEC are now detected by a commercially available molecular diarrheal panel, the Biofire FilmArray gastrointestinal panel (Biomerieux, Durham, NC) [2, 3].”
Background
Multicenter Clinical Validation of the Molecular BD Max Enteric Viral Panel for Detection of Enteric Pathogens
Stokes, W., Simner, P. J., Mortensen, J., Oethinger, M., Stellrecht, K., Lockamy, E., Lay, T., Bouchy, P., & Pillai, D. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.00306-19 · Cited by 19
“Other BD Max gastrointestinal panels had similar noncompliance rates (5, 6), which are comparable to those for other gastrointestinal multiplex PCR panels (1).”
BackgroundMethodResultInfluential
Amplification chemistries in clinical virology
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“These assays have demonstrated 94-100% sensitivity and > 94% specificity for the viral targets in the various clinical trial studies.”
Background
New Developments in Rapid Diagnostic Testing for Children
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“[24] [25] [26] [27] [28] [29] [30] [31] In fact, these multiplex panels result in increased and unexpected detections that would not be identified by the ordering preference of the clinician.”
Background
2017 Infectious Diseases Society of America Infectious Diarrhea Guidelines: A View From the Clinical Laboratory
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On-chip electrical detection of parallel loop-mediated isothermal amplification with DG-BioFETs for the detection of foodborne bacterial pathogens
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A Multisite Network Assessment of the Epidemiology and Etiology of Acquired Diarrhea among U.S. Military and Western Travelers (Global Travelers’ Diarrhea Study): A Principal Role of Norovirus among Travelers with Gastrointestinal Illness
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Detecting Cryptosporidium in Stool Samples Submitted to a Reference Laboratory.
Mergen, K., Espina, N., Teal, A. E., & Madison-Antenucci, S. (2020) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.19-0792 · Cited by 18
“testinal pathogens, including Cryptosporidium, have become available, and these are nowwidely used.(14,15) The commercial assays are easy to perform but can be costly.”
Background
Gastrointestinal Pathogen Colonization and the Microbiome in Asymptomatic Kidney Transplant Recipients
Westblade, L., Satlin, M., Albakry, S., Botticelli, B., Robertson, A. E., Alston, T., Magruder, M., Zhang, L. T., Edusei, E., Chan, K., et al. (2019) · Transplant Infectious Disease · doi:10.1111/tid.13167 · Cited by 18
Routine Broad-Range Fungal Polymerase Chain Reaction With DNA Sequencing in Patients With Suspected Mycoses Does Not Add Value and Is Not Cost-Effective
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“Unfortunately, molecular assays are usually more expensive than traditional methods, and some of the multiplex assays contain microbial targets that are not actionable with current therapeutic regimens.(5,6) Additionally, there is commonly a misconception that molecularly derived test results are superior to those fro…”
Background
Multiplex Nucleic Acid Amplification Testing to Diagnose Gut Infections
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DiarrheagenicEscherichia coliAssociated with Acute Gastroenteritis in Children from Soriano, Uruguay
Peirano, V., Bianco, M. N., Navarro, A., Schelotto, F., & Varela, G. (2018) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2018/8387218 · Cited by 19
КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ НАЦИОНАЛЬНОЙ АССОЦИАЦИИ СПЕЦИАЛИСТОВ ПО КОНТРОЛЮ ИНФЕКЦИЙ, СВЯЗАННЫХ С ОКАЗАНИЕМ МЕДИЦИНСКОЙ ПОМОЩИ, И ОБЩЕРОССИЙСКОЙ ОБЩЕСТВЕННОЙ НЕКОММЕРЧЕСКОЙ ОРГАНИЗАЦИИ «АССОЦИАЦИЯ КОЛОПРОКТОЛОГОВ РОССИИ» ПО ДИАГНОСТИКЕ, ЛЕЧЕНИЮ И ПРОФИЛАКТИКЕ CLOSTRIDIUM DIFFICILE-АССОЦИИРОВАННОЙ ДИАРЕИ (CDI)
Shelygin, Y. A., Алешкин, В. А., Sukhina, M. A., Mironov, A. Y., Briko, N. I., Kozlov, R. S., Zverev, V. V., Иванович, А. С., Kovalishena, O. V., Петровна, С. Е., et al. (2018) · Koloproktologia · doi:10.33878/2073-7556-2018-0-3-7-23 · Cited by 22
Development of a highly sensitive lateral immunochromatographic assay for rapid detection of Vibrio parahaemolyticus.
Liu, X., Guan, Y.-Y., Cheng, S.-L., Huang, Y.-D., Yan, Q., Zhang, J., Huang, G.-J., Zheng, J., & Liu, T. (2016) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2016.10.007 · Cited by 18
Real-time gastrointestinal infection surveillance through a cloud-based network of clinical laboratories
Ruzante, J. M., Olin, K., Muñoz, B., Nawrocki, J., Selvarangan, R., & Meyers, L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250767 · Cited by 18
“One example of an FDA-cleared molecular based CIDT, is the BioFire(1) FilmArray(1) Gastrointestinal (GI) Panel [12].”
BackgroundMethodResultInfluential
Rotavirus Genotype Trends and Gastrointestinal Pathogen Detection in the United States, 2014-16: Results from the New Vaccine Surveillance Network.
Esona, M., Ward, M., Wikswo, M. E., Rustempasic, S. M., Gautam, R., Perkins, C., Selvarangan, R., Harrison, C., Boom, J., Englund, J., et al. (2021) · Journal of Infectious Diseases · doi:10.1093/infdis/jiab177 · Cited by 17
“Other genotypes include G12P[4], G3P[4], G2P[8], G12P[6], G6P[8], G9P[4], G2P[6], G3P[6], and G4P[8].”
BackgroundInfluential
Comparison of Multiplex Gastrointestinal Pathogen Panel and Conventional Stool Testing for Evaluation of Patients With HIV Infection
Sobczyk, J., Jain, S., Sun, X.-Y., Karris, M., Wooten, D., Stagnaro, J., & Reed, S. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz547 · Cited by 17
“An outbreak of Cyclospora was detected by the FilmArray GPP one week before detection by conventional testing [14].”
MethodResult
Epidemiology and etiology of diarrhea in UK military personnel serving on the United Nations Mission in South Sudan in 2017: A prospective cohort study
Biswas, J. S., Lentaigne, J., Hill, N. E., Harrison, J. J., Mackenzie, H., Akorli, E., Burns, D. S., Hutley, E. J., Connor, P., & Woods, D. R. (2018) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2018.12.004 · Cited by 18
Use of the EntericBio Gastro Panel II in a diagnostic microbiology laboratory: challenges and opportunities
McAuliffe, G. N., Bissessor, L., Williamson, D. A., Moore, S., Wilson, J., Dufour, M., Taylor, S., & Upton, A. (2017) · Pathology · doi:10.1016/j.pathol.2017.02.003 · Cited by 18
New molecular diagnostic tools in traveller's diarrhea.
Vila, J. (2017) · Journal of Travel Medicine · doi:10.1093/jtm/taw071 · Cited by 17
“In a large study including 1556 stool specimens, Buss et al.25 compared the FilmArray GI panel with conventional stool cultures and molecular methods.”
Background
Detection and differentiation of norovirus genogroups I and II from clinical stool specimens using real-time PCR.
Ramanan, P., Espy, M., Khare, R., & Binnicker, M. (2017) · Diagnostic microbiology and infectious disease · doi:10.1016/j.diagmicrobio.2017.01.009 · Cited by 17
Barriers to implementation of rapid identification and antimicrobial susceptibility testing technologies in the clinical microbiology laboratory: an American perspective
Simons, C. C., & Capraro, G. A. (2024) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkae279 · Cited by 16
“These technologies have contributed to meaningful improvements to both patient care 5–7 and laboratory workflow, 8–10 begging the question: why have not more laboratories adopted them?”
Background
Microbial Etiologies and Clinical Characteristics of Children Seeking Emergency Department Care Due to Vomiting in the Absence of Diarrhea
Freedman, S. B., Xie, J., Lee, B. E., Ali, S., Pang, X.-L., Chui, L., Zhuo, R., Vanderkooi, O. G., Tellier, R., Funk, A. L., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab451 · Cited by 19
Hardwiring diagnostic stewardship using electronic ordering restrictions for gastrointestinal pathogen testing
Marcelin, J. R., Brewer, C., Beachy, M. W., Lyden, E. R., Winterboer, T., Murphy, C. N., Fey, P. D., Hood, L., & Schooneveld, T. C. V. (2019) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2019.78 · Cited by 16
Self-citation
The Distribution of Enteric Infections Utilizing Stool Microbial Polymerase Chain Reaction Testing in Clinical Practice
Axelrad, J. E., Joelson, A. M., Nobel, Y. R., Whittier, S., Lawlor, G. O., Riddle, M. S., Green, P. H. R., & Lebwohl, B. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5087-3 · Cited by 14
Reducing Uncertainty for Acute Febrile Illness in Resource-Limited Settings: The Current Diagnostic Landscape
Robinson, M. L., & Manabe, Y. C. (2017) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.16-0667 · Cited by 18
“pathogens within a syndrome, ranging from diarrhea to meningoencephalitis.(80,81) Using an isothermal technique named nicking endonuclease amplification reaction, Alere”
Method
Melting curve analysis reveals false-positive norovirus detection in a molecular syndromic panel
Matic, N., Lawson, T., Young, M., Jang, W., Bilawka, J., Gowland, L., Ritchie, G., Leung, V., Payne, M., Stefanovic, A., et al. (2024) · medRxiv · doi:10.1101/2024.02.23.24303102 · Cited by 15
Outbreak of Diarrhea Caused by a Novel Cryptosporidium hominis Subtype During British Military Training in Kenya
Toriro, R., Pallett, S., Woolley, S., Bennett, C., Hale, I., Heylings, J., Wilkins, D., Connelly, T., Muia, K., Avery, P., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae001 · Cited by 15
“On site, fresh fecal samples were analyzed for 22 pathogen targets (Supplementary Table 1) using the multiplex PCR BioFire FilmArray gastrointestinal (GI) panel, in accordance with the manufacturer's guidelines (bioMérieux, Marcy-l'Étoile, France) [6, 20].”
Method
Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial.
Brendish, N., Beard, K. R., Malachira, A. K., Tanner, A., Sanga-Nyirongo, L., Gwiggner, M., Cummings, J. R. F., Moyses, H., & Clark, T. (2023) · Lancet. Infectious Diseases (Print) · doi:10.1016/s1473-3099(23)00066-x · Cited by 15
Comparative Evaluation of Conventional Stool Testing and Multiplex Molecular Panel in Outpatients With Relapse of Inflammatory Bowel Disease.
Hong, S., Zaki, T., Main, M. L., Hine, A. M., Chang, S., Hudesman, D., & Axelrad, J. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa336 · Cited by 15
A Real-Time PCR Assay for Simultaneous Detection and Differentiation of Four Common Entamoeba Species That Infect Humans
Ali, I., & Roy, S. (2020) · Journal of Clinical Microbiology · doi:10.1128/jcm.01986-20 · Cited by 15
Point-of-care DNA testing by automatically and sequentially performing extraction, amplification and identification in a closed-type cassette
Dong, T.-H., Ma, X.-P., Sheng, N., Qi, X.-M., Chu, Y., Song, Q.-X., Zou, B., & Zhou, G.-H. (2020) · Sensors and actuators. B, Chemical · doi:10.1016/j.snb.2020.128919 · Cited by 15
Clinical evaluation of the APAS® Independence: Automated imaging and interpretation of urine cultures using artificial intelligence with composite reference standard discrepant resolution
Brenton, L., Waters, M. J., Stanford, T., & Giglio, S. (2020) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2020.106047 · Cited by 19
“Discrepant resolution is commonplace in clinical microbiology, however inherently biased approaches investigating only samples that disagree are often used (Buss et al., 2015; Faron et al., 2016b; Faron et al., 2015; Harrington et al., 2015; Kost et al., 2017; Mashock et al., 2017).”
Background
Preliminary evaluation of BioFire FilmArray® Gastrointestinal Panel for the detection of noroviruses and other enteric viruses from wastewater and shellfish
Gyawali, P., Croucher, D., & Hewitt, J. (2018) · Environmental science and pollution research international · doi:10.1007/s11356-018-2869-2 · Cited by 15
The Isolation of Vibrio cholera and Other Enteric Bacteria with Molecular Characterization of Vibrio cholera during the Outbreak of Baghdad/Iraq in 2015
Jameel, S. K., Shafek, M., Abdulmohsen, A., Mohamed, N. S., Naji, S., & Mohammed, T. T. (2016) · doi:10.4236/aim.2016.69069 · Cited by 15
“cholera; numerous diagnostic laboratory tests are applied [25] [26] including stool culture, biochemical test, specialized microscopy, serological test and these include polyvalent, Ogawa, Inaba antisera testing, and singleplex PCR, conventional coupled PCR or real-time PCR with fluorescence; for detecting different g…”
Method
Clinical impact of multiplex syndromic panels in the diagnosis of bloodstream, gastrointestinal, respiratory, and central nervous system infections
Abbott, A. N., & Fang, F. C. (2017) · Clinical Microbiology Newsletter · doi:10.1016/j.clinmicnews.2017.08.004 · Cited by 13
Multiplex Polymerase Chain Reaction Panels for Gastrointestinal Infections: Current Evidence, Regulatory Hurdles, and the Way Forward
Tansarli, G. S., Allen, D. R., & Fang, F. C. (2025) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaf445 · Cited by 15
“[21, 24, 40–42].”
The Impact of a Positive Biofire® FilmArray® Gastrointestinal Panel Result on Clinical Management and Outcomes
Carmon, D., Rohana, H., Azrad, M., & Peretz, A. (2023) · Diagnostics · doi:10.3390/diagnostics13061094 · Cited by 14
“%) and Sapovirus (5/17, 29.4%); and only one parasite (1/61, 1.6”
BackgroundInfluential
Impact of Rapid Molecular Multiplex Gastrointestinal Pathogen Testing in Management of Children during a Shigella Outbreak
Kanwar, N., Jackson, J., Bardsley, T., Pavia, A., Bourzac, K., Holmberg, K., & Selvarangan, R. (2023) · Journal of Clinical Microbiology · doi:10.1128/jcm.01652-22 · Cited by 14
Self-citation
High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations
Janowski, A. B., Owen, M. C., Dudley, H. M., López, T., Espinosa, R., Elvin-Lewis, M. P. F., Colichón, A., Arias, C. F., Burbelo, P. D., & Wang, D. (2021) · mSphere · doi:10.1128/msphere.00484-21 · Cited by 17
Evidence of False Positivity for Vibrio Species Tested by Gastrointestinal Multiplex PCR Panels, Minnesota, 2016-2018.
Decuir, M., Fowler, R., Cebelinski, E., Smith, K. E., Boxrud, D., & Medus, C. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab247 · Cited by 14
Rapid molecular syndromic testing for aetiological diagnosis of gastrointestinal infections and targeted antimicrobial prescription: experience from a reference paediatric hospital in Spain
Castany-Feixas, M., Simó, S., Garcia-Garcia, S., de Sevilla, M. F., Launes, C., Kalkgruber, M., Gené, A., Muñoz-Almagro, C., & Brotons, P. (2021) · European Journal of Clinical Microbiology and Infectious Diseases · doi:10.1007/s10096-021-04266-7 · Cited by 14
Clinical interpretation of enteric molecular diagnostic tests.
Tarr, G., Tarr, P., & Freedman, S. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.08.018 · Cited by 14
High-throughput screening of bacterial pathogens in clinical specimens using 16S rDNA qPCR and fragment analysis.
Wagner, K., Springer, B., Pires, V. P., & Keller, P. M. (2019) · Diagnostic microbiology and infectious disease · doi:10.1016/j.diagmicrobio.2018.11.006 · Cited by 14
“Recently, many syndromic point-of-care tests were launched that enable the detection of a panel of viral, bacterial, and fungal pathogens (Buss et al., 2015; Leber et al., 2016; Popowitch et al., 2013).”
Background
Etiologic and clinical characterization of community acquired gastroenteritis in adult patients in a Chilean emergency room by the FilmArray GI panel
Valenzuela, C., Legarraga, P., Peña, A., Arenas, Á., Berkowitz, L., Ramírez, G., Wozniak, A., García, P., & Álvarez-Lobos, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207850 · Cited by 20
Detection of Shiga toxin-producing and other diarrheagenic Escherichia coli by the BioFire FilmArray® Gastrointestinal Panel in human fecal samples
Rauw, K. D., Detemmerman, L., Breynaert, J., & Piérard, D. (2016) · European Journal of Clinical Microbiology and Infectious Diseases · doi:10.1007/s10096-016-2688-7 · Cited by 14
“EPEC and EAEC, two DEC types that are not routinely searched for in our laboratory, were frequently detected in our patients, and this was also seen in other studies conducted with the FA-GI Panel in the United States and Europe [1, 20, 21].”
BackgroundResultInfluential
Clinical impact of biofire gastrointestinal panel testing for hospitalised children with acute gastroenteritis
Sever, A., Ben-Zvi, H., Melamed, S., Sachs, N., Krause, I., & Bilavsky, E. (2022) · Acta paediatrica · doi:10.1111/apa.16610 · Cited by 13
The influence of hospitalization and HIV severity on gastrointestinal PCR panel evaluation of HIV-related acute diarrhea in New York City: a retrospective, cross-sectional study
Verma, A., Hine, A. M., Joelson, A., Mei, R.-N., Pitts, R., Lebwohl, B., & Axelrad, J. (2022) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848221092593 · Cited by 13
Aetiology of traveller's diarrhea: A nested case-control study.
Schaumburg, F., Correa-Martínez, C., Niemann, S., Köck, R., & Becker, K. (2020) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2020.101696 · Cited by 13
Evaluation of the BioFire FilmArray Gastrointestinal Panel and Real-Time Polymerase Chain Reaction Assays for the Detection of Major Diarrheagenic Pathogens by a Multicenter Diarrheal Disease Surveillance Program in China
Zhang, J.-Y., Guan, H.-X., Zhao, W.-S., Zhang, H., Wang, W., Ling, X., Xiao, Y., Guo, J.-Y., Huang, Z., Xu, Y., et al. (2019) · Foodborne pathogens and disease · doi:10.1089/fpd.2019.2642 · Cited by 13
“The correlation between pathogens and coinfections varied in different studies and may be affected by the sampling area and study population (Buss et al. , 2015; Alejo-Cancho et al. , 2017; Piralla et al. , 2017).”
Infection and propagation of astrovirus VA1 in cell culture
Janowski, A. B., & Wang, D. (2018) · Current Protocols in Microbiology · doi:10.1002/cpmc.73 · Cited by 13
Multiplex PCR for Detection and Identification of Microbial Pathogens
Poritz, M. A., & Lingenfelter, B. (2018) · Advanced Techniques in Diagnostic Microbiology · doi:10.1007/978-3-319-95111-9_19 · Cited by 13
“Studies using the FilmArray GI Panel identified a pathogen in 40–50% of stool samples [41, 45, 46].”
Method
Multicenter performance evaluation of the Unyvero IAI cartridge for detection of intra-abdominal infections
Ciesielczuk, H., Wilks, M., Castelain, S., Choquet, M., Morotti, M., Pluquet, E., Sambri, V., Tassinari, M., Zannoli, S., Cavalié, L., et al. (2018) · European Journal of Clinical Microbiology and Infectious Diseases · doi:10.1007/s10096-018-3345-0 · Cited by 13
Detection of Gastrointestinal Pathogens in Oncology Patients by Highly Multiplexed Molecular Panels
Otto, C. C., Chen, L.-H., He, T.-J., Tang, Y.-W., & Babady, N. (2017) · European Journal of Clinical Microbiology and Infectious Diseases · doi:10.1007/s10096-017-2981-0 · Cited by 13
“coli and their recovery in mixed infections is consistent with previous reports and unlikely to represent false-positive results or contamination, although these possibilities were not investigated further in our study [7, 9].”
Result
A randomized control trial of a multiplex gastrointestinal PCR panel versus usual testing to assess antibiotics use for patients with infectious diarrhea in the emergency department
Meltzer, A. C., Newton, S., Lange, J. J., Hall, N. C., Vargas, N. M., Huang, Y., Moran, S., & Ma, Y. (2022) · Journal of the American College of Emergency Physicians Open · doi:10.1002/emp2.12616 · Cited by 14
Prospective Investigation of an Automated PCR/Nucleic Acid Microarray-Based Platform for Enteric Pathogen Testing
Beckman, A. K., & Ferrieri, P. (2019) · Laboratory Medicine · doi:10.1093/labmed/lmz022 · Cited by 9
Case Report: Diagnosis of Cryptosporidiosis in Renal Transplantation in a Low-Prevalence Setting.
Zheng, S., Ko, K. K. K., Chan, K. S., & Venkatachalam, I. (2019) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.18-0651 · Cited by 12
“In this study, the comparator assay was real-time polymerase chain reaction (PCR).(7) Our case demonstrates host susceptibility, with infection in a renal transplant recipient presenting with a gastroenteritis syndrome.”
BackgroundMethod
High Relative Frequency of Enteroaggregative Escherichia coli among Patients with Reportable Enteric Pathogens, Minnesota, 2016-2017.
Beczkiewicz, A., Cebelinski, E., Decuir, M., Lappi, V., Wang, X., Smith, K. E., Boxrud, D., & Medus, C. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy890 · Cited by 12
Molecular detection of Enteropathogens from diarrheic stool of HIV positive patients in Gondar, Ethiopia
Seid, L., Stokes, W., Bayih, A., Getie, S., Abere, A., Tesfa, H., & Pillai, D. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3265-8 · Cited by 12
Multiplex Polymerase Chain Reaction for Detection of Gastrointestinal Pathogens in Migrant Workers in Qatar
Humphrey, J. M., Ranbhise, S. U., Ibrahim, E., Al‐Romaihi, H. E., Farag, E., Abu-Raddad, L. J., & Glesby, M. J. (2016) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.16-0464 · Cited by 12
“This finding is consistent with prior surveillance studies utilizing multiplex PCR.(9,12,28)”
BackgroundMethodResultInfluential
Use of a Molecular Panel To Aid in Diagnosis of Culture-Negative Meningitis
Bard, J. D., Naccache, S. N., & Bender, J. M. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.01957-16 · Cited by 13
Narrowing of the Diagnostic Gap of Acute Gastroenteritis in Children 0–6 Years of Age Using a Combination of Classical and Molecular Techniques, Delivers Challenges in Syndromic Approach Diagnostics
Steyer, A., Virant, M. J., Petrovec, M., Pokorn, M., Grosek, Š., Steyer, A. F., Šoba, B., Uršič, T., Cerar, T., Kolenc, M., et al. (2016) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001208 · Cited by 12
“Recently, many new or novel methods with a syndromic approach have been presented and have shown good sensitivity; some of them have already been Food and Drug Administration– approved.(74,75) With the implementation of such methods, co-infections will be noted more often.”
Background
Multidrug-resistant pathogens in UTIs: A concise review of epidemiology, diagnostics, and patent landscaping for precision healthcare.
Bhimani, A., Bhatt, T., Ibrahim, M., Detroja, A., Koradiya, J., Mandaliya, V. B., Maharshi, A., Sanghvi, G., & Bishoyi, A. K. (2025) · Diagnostic microbiology and infectious disease · doi:10.1016/j.diagmicrobio.2025.117125 · Cited by 11
Amoebic Liver Abscess: Potential Application of New Diagnostic Techniques for an Old Pathogen
Portunato, F., Bartalucci, C., Vena, A., Giacobbe, D., Porcile, E., Montanelli, P., Piol, N., Centanaro, M., Andorno, E., & Bassetti, M. (2024) · Infectious Disease and Therapy · doi:10.1007/s40121-024-00934-1 · Cited by 11
Proton pump Inhibitors and Risk of Enteric Infection in Inflammatory Bowel Disease: A Self-controlled Case Series
Varma, S., Trudeau, S. J., Li, J., & Freedberg, D. E. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad035 · Cited by 12

Authors: Buss, S. N., Leber, A., Chapin, K., Fey, P. D., Bankowski, M. J., Jones, M. K., Rogatcheva, M., Kanack, K. J., & Bourzac, K. M.
Affiliations: University of Nebraska Medical Center (US)
Nationwide Children's Hospital (US)
Lifespan (US)
University of Hawaiʻi at Mānoa (US)
BioFire Diagnostics (United States) (US)
ORCID: Buss, Sarah N.
Leber, Amy
Chapin, Kimberle
Fey, Paul D.
Jones, Matthew K.
Venue: Journal of Clinical Microbiology
Publisher: American Society for Microbiology
Published: 2015-03
Volume: 53
Issue: 3
Pages: 915-925
ISSN: 0095-1137 (ISSN-L)
1098-660X
DOI: 10.1128/jcm.02674-14
PMC: PMC4390666
OpenAlex: W2169792847
Cited by: 554
References: 0
Citations by year: 2026: 43 · 2025: 46 · 2024: 42 · 2023: 62 · 2022: 43 · 2021: 51 · 2020: 61 · 2019: 41 · 2018: 58 · 2017: 48 · 2016: 39 · 2015: 18
FWCI: 42.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Clinical Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: BioFire Diagnostics
National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI104593, R01AI089489)
Topics: Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords: infectious gastroenteritis, enteric pathogens, multiplex PCR, sensitivity and specificity, diarrheagenic Escherichia coli, norovirus, rotavirus, sapovirus, Cryptosporidium, Giardia lamblia, Shiga toxin-producing Escherichia coli, rapid molecular diagnostics
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Animals, Bacteria, Child, Child, Preschool, Feces, Female, Gastroenteritis, Humans, Infant, Infant, Newborn, Male, Microbiological Techniques, Middle Aged, Parasites, Prospective Studies, Sensitivity and Specificity, Time Factors, Viruses, Molecular Diagnostic Techniques, Young Adult

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Multicenter Evaluation of the BioFire FilmArray Gastrointestinal Panel for Etiologic Diagnosis of Infectious Gastroenteritis

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