Cited by 554Viral gastroenteritis research and epidemiologyBacterial Identification and Susceptibility TestingSalmonella and Campylobacter epidemiology

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Multicenter Evaluation of the BioFire FilmArray Gastrointestinal Panel for Etiologic Diagnosis of Infectious Gastroenteritis

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Buss, Sarah N., Leber, Amy, Chapin, Kimberle, Fey, Paul D., Bankowski, Matthew J., Jones, Matthew K., Rogatcheva, Margarita, Kanack, Kristen J., Bourzac, Kevin M.·2015·Journal of Clinical Microbiology

DOI 10.1128/jcm.02674-14PMC PMC4390666

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Abstract

The appropriate treatment and control of infectious gastroenteritis depend on the ability to rapidly detect the wide range of etiologic agents associated with the disease. Clinical laboratories currently utilize an array of different methodologies to test for bacterial, parasitic, and viral causes of gastroenteritis, a strategy that suffers from poor sensitivity, potentially long turnaround times, and complicated ordering practices and workflows. Additionally, there are limited or no testing methods routinely available for most diarrheagenic Escherichia coli strains, astroviruses, and sapoviruses. This study assessed the performance of the FilmArray Gastrointestinal (GI) Panel for the simultaneous detection of 22 different enteric pathogens directly from stool specimens: Campylobacter spp., Clostridium difficile (toxin A/B), Plesiomonas shigelloides , Salmonella spp., Vibrio spp., Vibrio cholerae , Yersinia enterocolitica , enteroaggregative E. coli , enteropathogenic E. coli , enterotoxigenic E. coli , Shiga-like toxin-producing E. coli ( stx 1 and stx 2 ) (including specific detection of E. coli O157), Shigella spp./enteroinvasive E. coli , Cryptosporidium spp., Cyclospora cayetanensis , Entamoeba histolytica , Giardia lamblia , adenovirus F 40/41, astrovirus, norovirus GI/GII, rotavirus A, and sapovirus. Prospectively collected stool specimens ( n = 1,556) were evaluated using the BioFire FilmArray GI Panel and tested with conventional stool culture and molecular methods for comparison. The FilmArray GI Panel sensitivity was 100% for 12/22 targets and ≥94.5% for an additional 7/22 targets. For the remaining three targets, sensitivity could not be calculated due to the low prevalences in this study. The FilmArray GI Panel specificity was ≥97.1% for all panel targets. The FilmArray GI Panel provides a comprehensive, rapid, and streamlined alternative to conventional methods for the etiologic diagnosis of infectious gastroenteritis in the laboratory setting. The potential advantages include improved performance parameters, a more extensive menu of pathogens, and a turnaround time of as short as 1 h.

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Berthelot, S., Boissinot, M., Bergeron, M., Vachon, M., Trottier, S., Huletsky, A., Gilca, R., Guertin, J., Tremblay, C., Longtin, Y., et al. (2023) · medRxiv · doi:10.1101/2023.10.12.23296964
“These panels have demonstrated high sensitivity and specificity(19-22).”
Evaluating outpatient diagnostic stewardship of comprehensive polymerase chain reaction Clostridioides difficile testing in a regional health system
Golovaty, I., & Tulloch-Palomino, L. G. (2023) · Antimicrobial Stewardship and Healthcare Epidemiology · doi:10.1017/ash.2023.426
Utility of BioFire FilmArray Gastrointestinal Panel in the Diagnosis of Gastrointestinal Infections
Gupta, R., Gupta, V., Sood, A., Singh, A., Chaudhary, J., Gupta, M., & Aggarwal, M. (2023) · JOURNAL OF GASTROINTESTINAL INFECTIONS · doi:10.1055/s-0043-1776421
“10,11 The study aimed to investigate the role and utility of FilmArray GIP in the diagnosis of GIs.”
Intérêt du diagnostic rapide BioFire dans les infections respiratoires et gastro-intestinales aux urgences
Bertholom, C. (2023) · Option/Bio · doi:10.1016/s0992-5945(23)00176-9
Differences by transplant type in stool multiplex PCR testing for acute diarrhea in post-solid organ transplantation
Verma, A., Hine, A. M., Joelson, A., Mei, R.-N., Lebwohl, B., & Axelrad, J. (2022) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2022.1064187
“5% and 100% (15, 16) The pathogens are: Campylobacter jejuni, Clostridioides difficile (toxin A/B), Plesiomonas shigelloides, Salmonella species, Yersinia enterocolitica, Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio cholerae, enteroaggregative Escherichia coli (EAEC), enteropathogenic E.”
Background
Study of Enteropathogenic Escherichia coli producing Extended Spectrum β-lactamase in Children with Acute Gastroenteritis
Elkasaby, N., Alsayed, M., Zaki, M. E. S., Bakr, A., & Rizk, M. (2022) · The Egyptian Journal of Medical Microbiology · doi:10.21608/ejmm.2022.248898
Infections à « Campylobacter »
Mégraud, F., & Bessède, E. (2022) · EMC - Maladies Infectieuses · doi:10.1016/s1166-8598(21)44820-9
Infections à Cyclospora
Jeddi, F., Lavergne, R., Pape, P. L., & Morio, F. (2022) · EMC - Maladies Infectieuses · doi:10.1016/s1166-8598(21)44959-8
Multiplex Molecular Stool Testing Rarely Impacts Antimicrobial Treatment Decisions More Than Three Days After Admission
Aleem, A., Firak, G., & Slenker, A. (2021) · Cureus · doi:10.7759/cureus.14784
“Conventional testing methods are increasingly being replaced by multiplex molecular stool testing, which provides an improved detection rate for multiple pathogens simultaneously with a high sensitivity and a rapid turnaround time [7-9].”
Method
Performance Characteristics of the TaqMan Array PCR on Repository Stool Specimens and Smears on Whatman® FTA Elute Cards
Tisdale, M. D., Mitra, I., Mccoy, A. J., Simons, M., Reynolds, N. D., Swierczewski, B., Liu, J., Houpt, E., Fraser, J. A., Riddle, M., et al. (2020) · doi:10.21203/rs.3.rs-48924/v1
“The results show a lower than expected PPA of TAC on archival samples and signi cant variability in PPA estimates by pathogen when compared to previously published estimates [4, 5].”
BackgroundResult
Isolate independent molecular typing improves the yield of O typing of infections due to Shiga toxin producing Escherichia coli.
McAuliffe, G., Tse, F., Qiao, H., Moore, S., Bissessor, L., Thompson, B., McLaughlin, V., Upton, A., & Taylor, S. (2020) · Pathology (Sydney) · doi:10.1016/j.pathol.2020.02.008
Community acquired Clostridium difficile in an infant without antibiotic exposure
Singh, J., & Vyas, R. (2020) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_702_19
“difficile with PCR assay, a very sensitive and specific finding.[8] So, the possibilities of C.”
Background
Replacement of Culture with Molecular Testing for Diagnosis Infectious Diseases
Capraro, G. (2018) · Advances in Molecular Pathology · doi:10.1016/j.yamp.2018.07.002
Molecular Microbiology
Nolte, F. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-816061-9.00005-9
“9%.(244) Asymptomatic infections with C.”
The Utility of Multiplex Molecular Tests for Enteric Pathogens: a Micro-Comic Strip
McAdam, A. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.01916-17
Viral Gastroenteritis
Leshem, E., & Lopman, B. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-40181-4.00056-6 · Cited by 2
Emerging Technologies in Diagnostic Virology and Antiviral Strategies
Patra, G., & Mukhopadhyay, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-58675-1_97-1
Appendicitis and Infections of the Appendix
Hosseini, M., & Lamps, L. (2019) · Gastrointestinal Diseases and their Associated Infections · doi:10.1016/b978-0-323-54843-4.00008-8
Molecular Diagnosis of Gastrointestinal Infections
Babady, E., & Mead, P. (2019) · Gastrointestinal Diseases and their Associated Infections · doi:10.1016/b978-0-323-54843-4.00013-1
Bacterial Gastroenteritis
Keddy, K., & Smith, A. (2019) · Gastrointestinal Diseases and their Associated Infections · doi:10.1016/b978-0-323-54843-4.00012-x

Authors: Buss, S. N., Leber, A., Chapin, K., Fey, P. D., Bankowski, M. J., Jones, M. K., Rogatcheva, M., Kanack, K. J., & Bourzac, K. M.
Affiliations: University of Nebraska Medical Center (US)
Nationwide Children's Hospital (US)
Lifespan (US)
University of Hawaiʻi at Mānoa (US)
BioFire Diagnostics (United States) (US)
ORCID: Buss, Sarah N.
Leber, Amy
Chapin, Kimberle
Fey, Paul D.
Jones, Matthew K.
Venue: Journal of Clinical Microbiology
Publisher: American Society for Microbiology
Published: 2015-03
Volume: 53
Issue: 3
Pages: 915-925
ISSN: 0095-1137 (ISSN-L)
1098-660X
DOI: 10.1128/jcm.02674-14
PMC: PMC4390666
OpenAlex: W2169792847
Cited by: 554
References: 0
Citations by year: 2026: 43 · 2025: 46 · 2024: 42 · 2023: 62 · 2022: 43 · 2021: 51 · 2020: 61 · 2019: 41 · 2018: 58 · 2017: 48 · 2016: 39 · 2015: 18
FWCI: 42.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Clinical Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: BioFire Diagnostics
National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI104593, R01AI089489)
Topics: Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords: infectious gastroenteritis, enteric pathogens, multiplex PCR, sensitivity and specificity, diarrheagenic Escherichia coli, norovirus, rotavirus, sapovirus, Cryptosporidium, Giardia lamblia, Shiga toxin-producing Escherichia coli, rapid molecular diagnostics
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Animals, Bacteria, Child, Child, Preschool, Feces, Female, Gastroenteritis, Humans, Infant, Infant, Newborn, Male, Microbiological Techniques, Middle Aged, Parasites, Prospective Studies, Sensitivity and Specificity, Time Factors, Viruses, Molecular Diagnostic Techniques, Young Adult

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Multicenter Evaluation of the BioFire FilmArray Gastrointestinal Panel for Etiologic Diagnosis of Infectious Gastroenteritis

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