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Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay
Open accessAbstract
A 96-well microtiter infection assay for the human immunodeficiency virus (HIV) is described. The assay utilizes human T-cell lymphotropic virus type I-immortalized MT-2 cells as targets for infection and requires only 4 to 5 days for completion. Cytolysis was quantitated by vital dye uptake of poly-L-lysine-adhered cells as an endpoint for infection. The assay's efficacy was proven by the sensitive and accurate assessment of several known anti-HIV agents including two inhibitors of reverse transcription (3'-azido-3'-deoxythymidine and 2',3'-dideoxycytidine), three biological response modifiers (recombinant interferons alpha and beta and mismatched double-stranded RNA), a direct inactivator of HIV virions (amphotericin B), and neutralizing antibodies from two HIV-positive human subjects. Evaluation of data was facilitated by computer-assisted analysis. This assay provides a means for rapid, sensitive, and inexpensive large-scale in vitro testing of potential anti-HIV therapeutic regimens and quantitation of HIV-neutralizing antibody titers.
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Cited by
Li, M., Gao, F., Mascola, J. R., Stamatatos, L., Polonis, V. R., Koutsoukos, M., Voss, G., Goepfert, P., Gilbert, P., Greene, K. M., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.16.10108-10125.2005 · Cited by 1,070
Self-citationStudies in Subjects with Long-Term Nonprogressive Human Immunodeficiency Virus Infection
Pantaleo, G., Menzo, S., Vaccarezza, M., Graziosi, C., Cohen, O. J., Demarest, J. F., Montefiori, D., Orenstein, J. M., Fox, C., Schrager, L. K., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501263320402 · Cited by 730
Self-citationGene inoculation generates immune responses against human immunodeficiency virus type 1.
Wang, B., Ugen, K. E., Srikantan, V, Agadjanyan, M. G., Dang, K., Refaeli, Y., Sato, A. I., Boyer, J., Williams, W. V., & Weiner, D. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4156 · Cited by 655
Seaman, M. S., Janes, H., Hawkins, N., Grandpre, L. E., Devoy, C., Giri, A., Coffey, R. T., Harris, L., Wood, B., Daniels, M. G., et al. (2010) · Journal of Virology · doi:10.1128/jvi.02108-09 · Cited by 632
Self-citationSarzotti-Kelsoe, M., Bailer, R. T., Turk, E., Lin, C.-L., Bilska, M., Greene, K. M., Gao, H., Todd, C. A., Ozaki, D. A., Seaman, M. S., et al. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.11.022 · Cited by 532
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Metadata
- Authors
- Montefiori, D. C., Robinson, W. E., Schuffman, S. S., & Mitchell, W. M.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1988-02
- Volume
- 26
- Issue
- 2
- Pages
- 231-235
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W1778074134
- Cited by
- 201
- References
- 0
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Montefiori, D. C., Robinson, W. E., Schuffman, S. S., & Mitchell, W. M. (1988). Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.26.2.231-235.1988
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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