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Increasing Incidence of Candidemia: Results from a 20-Year Nationwide Study in Iceland
Open accessAbstract
A nationwide study on candidemia was conducted in Iceland from 1980 to 1999. The annual incidence increased from 1.4 cases/100,000 inhabitants/year between 1980 and 1984 to 4.9 cases/100,000 inhabitants/year between 1995 and 1999 (P < 0.0001). Candidemia episodes at university hospitals increased from 0.15/1,000 admissions to 0.55/1,000 admissions (P < 0.0001). Candida albicans was the predominant species responsible (64.4%). The national import of fluconazole increased approximately fourfold during the second half of the study, but increased resistance to this agent was not observed.
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“Fluconazole has been the focus of resistance surveillance efforts since its introduction in the early 1990s (11, 33, 35, 47-49, 92, 98, 107, 108, 113, 207, 212, 217, 221, 259, 279, 290).”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [11]
In the citing paper
“Candida bloodstream infections are increasingly frequent [101,102] and are often associated with clinical evidence of sepsis syndrome and high associated attributable mortality [103, 104].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [101]
In the citing paper
“and recent surveys from France (254), Italy (139, 289), Switzerland (147), Finland (234), Iceland (11), Taiwan (33, 34, 107, 108), and Norway (259) indicate that C. glabrata has not increased as a cause of IC to the extent in the United States despite an increase in the use of fluconazole in each of those countries.”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [11]
In the citing paper
“Although the association with fluconazole use and increased isolation of C. glabrata is well known (1, 10, 148, 311, 319), the evidence is strongest for cancer centers and less so for individual nonspecialty hospitals (11, 33, 131, 145, 147, 259).”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [11]
In the citing paper
“Many such surveys have now been published and include studies of isolates from ICU patients and of nosocomial and community-onset BSIs in several different countries (5, 10, 11, 33, 34, 35, 41, 49, 92, 104, 107, 108, 113, 183, 207, 212, 217, 218, 221, 224, 230, 234, 259, 279, 289, 290, 323).”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [11]
In the citing paper
“These data are highly representative of those published in numerous in vitro studies of Candida BSI isolates (11, 33, 35, 47-49, 92, 107, 108, 113, 259, 279, 290).”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [11]
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Metadata
- Authors
- Ásmundsdóttir, L. R., Erlendsdóttir, H., & Gottfredsson, M.
- Affiliations
- University of Iceland, Reykjavik 101Departments of
- Clinical Microbiology
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2002-09
- Volume
- 40
- Issue
- 9
- Pages
- 3489-3492
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC130691
- OpenAlex
- W2147785178
- Cited by
- 188
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 10 · 2013: 11 · 2012: 13
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- candidemia, incidence trends, Candida albicans, antifungal resistance, hospitalization, invasive fungal infections, Iceland
- MeSH terms
- Adolescent, Adult, Aged, Antifungal Agents, Blood, Candida, Candida albicans, Candidiasis, Child, Child, Preschool, Culture Media, Humans, Iceland, Infant, Microbial Sensitivity Tests, Middle Aged, Incidence, Fungemia, Age Distribution
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