The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Properties and Dissemination of H5N1 Viruses Isolated during an Influenza Outbreak in Migratory Waterfowl in Western China
Abstract
H5N1 influenza A viruses are widely distributed among poultry in Asia, but until recently, only a limited number of wild birds were affected. During late April through June 2005, an outbreak of H5N1 virus infection occurred among wild birds at Qinghai Lake in China. Here, we describe the features of this outbreak. First identified in bar-headed geese, the disease soon spread to other avian species populating the lake. Sequence analysis of 15 viruses representing six avian species and collected at different times during the outbreak revealed four different H5N1 genotypes. Most of the isolates possessed lysine at position 627 in the PB2 protein, a residue known to be associated with virulence in mice and adaptation to humans. However, neither of the two index viruses possessed this residue. All of the viruses tested were pathogenic in mice, with the exception of one index virus. We also tested the replication of two viruses isolated during the Qinghai Lake outbreak and one unrelated duck H5N1 virus in rhesus macaques. The Qinghai Lake viruses did not replicate efficiently in these animals, producing no evidence of disease other than transient fever, while the duck virus replicated in multiple organs and caused symptoms of respiratory illness. Importantly, H5N1 viruses isolated in Mongolia, Russia, Inner Mongolia, and the Liaoning Province of China after August 2005 were genetically closely related to one of the genotypes isolated during the Qinghai outbreak, suggesting the dominant nature of this genotype and underscoring the need for worldwide intensive surveillance to minimize its devastating consequences.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12
REED, L. J., & MUENCH, H. (1938) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a118408 · Cited by 19,926
A simple method of estimating 50 per cent end points
Muench, H. (1938) · Medical Entomology and Zoology · Cited by 8,376
Evolution and ecology of influenza A viruses
Webster, R. G., Bean, W. J., Gorman, O. T., Chambers, T. M., & Kawaoka, Y. (1992) · Microbiological Reviews · doi:10.1128/mr.56.1.152-179.1992 · Cited by 4,739
Self-citationHuman influenza A H5N1 virus related to a highly pathogenic avian influenza virus
Claas, E. C., Osterhaus, A. D., van Beek, R., De Jong, J. C., Rimmelzwaan, G. F., Senne, D. A., Krauss, S., Shortridge, K. F., & Webster, R. G. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11212-0 · Cited by 1,429
Subbarao, K., Klimov, A., Katz, J., Regnery, H., Lim, W., Hall, H., Perdue, M., Swayne, D., Bender, C., Huang, J., et al. (1998) · Science · doi:10.1126/science.279.5349.393 · Cited by 1,362
Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses
Hatta, M., Gao, P., Halfmann, P., & Kawaoka, Y. (2001) · Science · doi:10.1126/science.1062882 · Cited by 1,338
Self-citationFouchier, R. A. M., Schneeberger, P. M., Rozendaal, F. W., Broekman, J. M., Kemink, S. A. G., Munster, V., Kuiken, T., Rimmelzwaan, G. F., Schutten, M., van Doornum, G. J. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308352100 · Cited by 1,088
Characterization of the 1918 influenza virus polymerase genes
Taubenberger, J. K., Reid, A. H., Lourens, R. M., Wang, R., Jin, G., & Fanning, T. G. (2005) · Nature · doi:10.1038/nature04230 · Cited by 1,066
Yuen, K., Chan, P., Peiris, M., Tsang, D., Que, T., Shortridge, K., Cheung, P., To, W., Ho, E., Sung, R., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01182-9 · Cited by 1,052
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range
Subbarao, E. K., London, W., & Murphy, B. R. (1993) · Journal of Virology · doi:10.1128/jvi.67.4.1761-1764.1993 · Cited by 933
Cited by
Jiao, P., Tian, G., Li, Y., Deng, G., Jiang, Y., Liu, C., Liu, W., Bu, Z., Kawaoka, Y., & Chen, H. (2008) · Journal of Virology · doi:10.1128/jvi.01698-07 · Cited by 469
Self-citationThe Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds
Dugan, V. G., Chen, R., Spiro, D. J., Sengamalay, N., Zaborsky, J., Ghedin, E., Nolting, J., Swayne, D. E., Runstadler, J. A., Happ, G. M., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000076 · Cited by 396
Human infection with highly pathogenic H5N1 influenza virus
Gambotto, A., Barratt-Boyes, S. M., de Jong, M. D., Neumann, G., & Kawaoka, Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60627-3 · Cited by 316
Self-citationFan, S., Deng, G., Song, J., Tian, G., Suo, Y., Jiang, Y., Guan, Y., Bu, Z., Kawaoka, Y., & Chen, H. (2009) · Virology · doi:10.1016/j.virol.2008.11.044 · Cited by 274
Self-citation
Metadata
- Authors
- Chen, H., Li, Y., Li, Z., Shi, J., Shinya, K., Deng, G., Qi, Q., Tian, G., Fan, S., Zhao, H., Sun, Y., & Kawaoka, Y.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2006-06-15
- Volume
- 80
- Issue
- 12
- Pages
- 5976-5983
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2136494098
- Cited by
- 375
- References
- 24
- FWCI
- 25.68
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Properties and Dissemination of H5N1 Viruses Isolated during an Influenza Outbreak in Migratory Waterfowl in Western China. https://app.cochat.ai/papers/10.1128/jvi.00110-06
- The paper
- Chen, H., Li, Y., Li, Z., Shi, J., Shinya, K., Deng, G., Qi, Q., Tian, G., Fan, S., Zhao, H., Sun, Y., & Kawaoka, Y. (2006). Properties and Dissemination of H5N1 Viruses Isolated during an Influenza Outbreak in Migratory Waterfowl in Western China. Journal of Virology. https://doi.org/10.1128/jvi.00110-06
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
