The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection
Open accessAbstract
The study of the evolution and specificities of neutralizing antibodies during the course of human immunodeficiency virus type 1 (HIV-1) infection may be important in the discovery of possible targets for vaccine design. In this study, we assessed the autologous and heterologous neutralization responses of 14 HIV-1 subtype C-infected individuals, using envelope clones obtained within the first 2 months postinfection. Our data show that potent but relatively strain-specific neutralizing antibodies develop within 3 to 12 months of HIV-1 infection. The magnitude of this response was associated with shorter V1-to-V5 envelope lengths and fewer glycosylation sites, particularly in the V1-V2 region. Anti-MPER antibodies were detected in 4 of 14 individuals within a year of infection, while antibodies to CD4-induced (CD4i) epitopes developed to high titers in 12 participants, in most cases before the development of autologous neutralizing antibodies. However, neither anti-MPER nor anti-CD4i antibody specificity conferred neutralization breadth. These data provide insights into the kinetics, potency, breadth, and epitope specificity of neutralizing antibody responses in acute HIV-1 subtype C infection.
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McMichael, A. J., Borrow, P., Tomaras, G. D., Goonetilleke, N., & Haynes, B. F. (2010) · Nature Reviews Immunology · doi:10.1038/nri2674 · Cited by 871
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Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning
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Metadata
- Authors
- Gray, E. S., Moore, P. L., Choge, I. A., Decker, J. M., Bibollet-Ruche, F., Li, H., Leseka, N., Treurnicht, F., Mlisana, K., Shaw, G. M., Karim, S. S. A., Williamson, C., & Morris, L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-06-15
- Volume
- 81
- Issue
- 12
- Pages
- 6187-6196
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2126654882
- Cited by
- 299
- References
- 18
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Gray, E. S., Moore, P. L., Choge, I. A., Decker, J. M., Bibollet-Ruche, F., Li, H., Leseka, N., Treurnicht, F., Mlisana, K., Shaw, G. M., Karim, S. S. A., Williamson, C., & Morris, L. (2007). Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection. Journal of Virology. https://doi.org/10.1128/jvi.00239-07
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
