The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Infection of Human Airway Epithelium by Human and Avian Strains of Influenza A Virus
Open accessAbstract
We describe the characterization of influenza A virus infection of an established in vitro model of human pseudostratified mucociliary airway epithelium (HAE). Sialic acid receptors for both human and avian viruses, α-2,6- and α-2,3-linked sialic acids, respectively, were detected on the HAE cell surface, and their distribution accurately reflected that in human tracheobronchial tissue. Nonciliated cells present a higher proportion of α-2,6-linked sialic acid, while ciliated cells possess both sialic acid linkages. Although we found that human influenza viruses infected both ciliated and nonciliated cell types in the first round of infection, recent human H3N2 viruses infected a higher proportion of nonciliated cells in HAE than a 1968 pandemic-era human virus, which infected proportionally more ciliated cells. In contrast, avian influenza viruses exclusively infected ciliated cells. Although a broad-range neuraminidase abolished infection of HAE by human parainfluenza virus type 3, this treatment did not significantly affect infection by influenza viruses. All human viruses replicated efficiently in HAE, leading to accumulation of nascent virus released from the apical surface between 6 and 24 h postinfection with a low multiplicity of infection. Avian influenza A viruses also infected HAE, but spread was limited compared to that of human viruses. The nonciliated cell tropism of recent human H3N2 viruses reflects a preference for the sialic acid linkages displayed on these cell types and suggests a drift in the receptor binding phenotype of the H3 hemagglutinin protein as it evolves in humans away from its avian virus precursor.
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Cites
Influenza virus receptors in the human airway
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Cited by
Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H., Pickles, R. J., & Ting, J. P.-Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.005 · Cited by 1,113
Self-citationRole of receptor binding specificity in influenza A virus transmission and pathogenesis
de Graaf, M., & Fouchier, R. A. M. (2014) · The EMBO Journal · doi:10.1002/embj.201387442 · Cited by 435
H5N1 infection of the respiratory tract and beyond: a molecular pathology study
Gu, J., Xie, Z., Gao, Z., Liu, J., Korteweg, C., Ye, J., Lau, L. T., Lu, J., Gao, Z., Zhang, B., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61515-3 · Cited by 375
Replication and Transmission of H9N2 Influenza Viruses in Ferrets: Evaluation of Pandemic Potential
Wan, H., Sorrell, E. M., Song, H., Hossain, M. J., Ramirez-Nieto, G., Monne, I., Stevens, J., Cattoli, G., Capua, I., Chen, L.-M., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002923 · Cited by 289
Metadata
- Authors
- Thompson, C. I., Barclay, W. S., Zambon, M. C., & Pickles, R. J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2006-08-15
- Volume
- 80
- Issue
- 16
- Pages
- 8060-8068
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2106258444
- Cited by
- 256
- References
- 40
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- green
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