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Cited by 289

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Functional Characterization of Negri Bodies (NBs) in Rabies Virus-Infected Cells: Evidence that NBs Are Sites of Viral Transcription and Replication

Open access
Lahaye, Xavier, Vidy, Aurore, Pomier, Carole, Obiang, Linda, Harper, Francis, Gaudin, Yves, Blondel, Danielle·2009·Journal of Virology
DOI 10.1128/jvi.00554-09
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Abstract

Rabies virus infection induces the formation of cytoplasmic inclusion bodies that resemble Negri bodies found in the cytoplasm of some infected nerve cells. We have studied the morphogenesis and the role of these Negri body-like structures (NBLs) during viral infection. The results indicate that these spherical structures (one or two per cell in the initial stage of infection), composed of the viral N and P proteins, grow during the virus cycle before appearing as smaller structures at late stages of infection. We have shown that the microtubule network is not necessary for the formation of these inclusion bodies but is involved in their dynamics. In contrast, the actin network does not play any detectable role in these processes. These inclusion bodies contain Hsp70 and ubiquitinylated proteins, but they are not misfolded protein aggregates. NBLs, in fact, appear to be functional structures involved in the viral life cycle. Specifically, using in situ fluorescent hybridization techniques, we show that all viral RNAs (genome, antigenome, and every mRNA) are located inside the inclusion bodies. Significantly, short-term RNA labeling in the presence of BrUTP strongly suggests that the NBLs are the sites where viral transcription and replication take place.

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Research works printed but not linked: 14

  1. 10.1099/0022-1317-75-11-2889 · doi:10.1099/0022-1317-75-11-2889
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  3. 10.1073/pnas.87.17.6579 · doi:10.1073/pnas.87.17.6579
  4. 10.1016/0166-0934(89)90095-5 · doi:10.1016/0166-0934(89)90095-5
  5. 10.1128/jvi.65.6.2839-2844.1991 · doi:10.1128/jvi.65.6.2839-2844.1991
  6. 10.1128/JVI.74.21.10217-10222.2000 · doi:10.1128/jvi.74.21.10217-10222.2000
  7. 10.1016/0022-510X(86)90093-6 · doi:10.1016/0022-510x(86)90093-6
  8. 10.1016/0042-6822(62)90099-5 · doi:10.1016/0042-6822(62)90099-5
  9. 10.1128/jvi.14.4.981-996.1974 · doi:10.1128/jvi.14.4.981-996.1974
  10. Negri, A. 1903. Contributo allo studio dell'eziologia della rabia. Bol. Soc. Med. Chir. Pavia1903:88-114.
  11. 10.1099/0022-1317-82-11-2691 · doi:10.1099/0022-1317-82-11-2691
  12. 10.1099/0022-1317-78-1-119 · doi:10.1099/0022-1317-78-1-119
  13. 10.1016/0042-6822(92)90923-D · doi:10.1016/0042-6822(92)90923-d
  14. 10.2105/AJPH.17.10.1080 · doi:10.2105/ajph.17.10.1080

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Metadata

Authors
Lahaye, X., Vidy, A., Pomier, C., Obiang, L., Harper, F., Gaudin, Y., & Blondel, D.
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2009-08-15
Volume
83
Issue
16
Pages
7948-7958
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.00554-09
OpenAlex
W1978826641
Cited by
289
References
26
FWCI
4.27
Type
journal article
Language
en
Open access
green
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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CoChat. (2026). Citation check: Functional Characterization of Negri Bodies (NBs) in Rabies Virus-Infected Cells: Evidence that NBs Are Sites of Viral Transcription and Replication. https://app.cochat.ai/papers/10.1128/jvi.00554-09
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Lahaye, X., Vidy, A., Pomier, C., Obiang, L., Harper, F., Gaudin, Y., & Blondel, D. (2009). Functional Characterization of Negri Bodies (NBs) in Rabies Virus-Infected Cells: Evidence that NBs Are Sites of Viral Transcription and Replication. Journal of Virology. https://doi.org/10.1128/jvi.00554-09

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.