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Interaction of the Rabies Virus P Protein with the LC8 Dynein Light Chain
Open accessAbstract
The rabies virus P protein is involved in viral transcription and replication but its precise function is not clear. We investigated the role of P (CVS strain) by searching for cellular partners by using a two-hybrid screening of a PC12 cDNA library. We isolated a cDNA encoding a 10-kDa dynein light chain (LC8). LC8 is a component of cytoplasmic dynein involved in the minus end-directed movement of organelles along microtubules. We confirmed that this molecule interacts with P by coimmunoprecipitation in infected cells and in cells transfected with a plasmid encoding P protein. LC8 was also detected in virus particles. Series of deletions from the N- and C-terminal ends of P protein were used to map the LC8-binding domain to the central part of P (residues 138 to 172). These results are relevant to speculate that dynein may be involved in the axonal transport of rabies virus along microtubules through neuron cells.
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Cited by
Li, Y., Bai, W., & Hashikawa, T. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25728 · Cited by 2,266
The cell biology of rabies virus: using stealth to reach the brain
Schnell, M. J., McGettigan, J. P., Wirblich, C., & Papaneri, A. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2260 · Cited by 391
Lahaye, X., Vidy, A., Pomier, C., Obiang, L., Harper, F., Gaudin, Y., & Blondel, D. (2009) · Journal of Virology · doi:10.1128/jvi.00554-09 · Cited by 289
Self-citationMatsuda, K., Park, C. H., Sunden, Y., Kimura, T., Ochiai, K., Kida, H., & Umemura, T. (2004) · Veterinary Pathology · doi:10.1354/vp.41-2-101 · Cited by 189
Diversity of oxytocin neurones: Beyond magno‐ and parvocellular cell types?
Althammer, F., & Grinevich, V. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12549 · Cited by 138
Metadata
- Authors
- Raux, H., Flamand, A., & Blondel, D.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-11
- Volume
- 74
- Issue
- 21
- Pages
- 10212-10216
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2103617829
- Cited by
- 297
- References
- 0
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Raux, H., Flamand, A., & Blondel, D. (2000). Interaction of the Rabies Virus P Protein with the LC8 Dynein Light Chain. Journal of Virology. https://doi.org/10.1128/jvi.74.21.10212-10216.2000
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