Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358 · see citing works

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

Kägi, D., Ledermann, B., Bürki, K., Seiler, P. J., Odermatt, B., Olsen, K. J., Podack, E. R., Zinkernagel, R. M., & Hengartner, H. (1994) · Nature · doi:10.1038/369031a0 · Cited by 1,758 · see citing works

The IL-1 family: regulators of immunity

Sims, J. E., & Smith, D. E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2691 · Cited by 1,416 · see citing works

Hide and seek: an introduction to steganography

Provos, N., & Honeyman, P. (2003) · IEEE Security & Privacy · doi:10.1109/msecp.2003.1203220 · Cited by 1,295 · see citing works

Anti-inflammatory Agents: Present and Future

Dinarello, C. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.043 · Cited by 1,095 · see citing works

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

Grossman, W. J., Verbsky, J. W., Barchet, W., Colonna, M., Atkinson, J. P., & Ley, T. J. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.002 · Cited by 1,021 · see citing works

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,009 · see citing works

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H., & Ley, T. J. (1994) · Cell · doi:10.1016/0092-8674(94)90376-x · Cited by 815 · see citing works

IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS

Guidotti, L. G., & Chisari, F. V. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100230 · Cited by 807 · see citing works

Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells

Curtsinger, J., Schmidt, C. S., Mondino, A., Lins, D. C., Kedl, R. M., Jenkins, M. K., & Mescher, M. F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3256 · Cited by 610 · see citing works

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

Kägi, D., Ledermann, B., Bürki, K., Zinkernagel, R. M., & Hengartner, H. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.207 · Cited by 582 · see citing works

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

Ben-Sasson, S. Z., Hu-Li, J., Quiel, J., Cauchetaux, S., Ratner, M., Shapira, I., Dinarello, C. A., & Paul, W. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902745106 · Cited by 568 · see citing works

Acquisition of Murine NK Cell Cytotoxicity Requires the Translation of a Pre-existing Pool of Granzyme B and Perforin mRNAs

Fehniger, T. A., Cai, S. F., Cao, X., Bredemeyer, A. J., Presti, R. M., French, A. R., & Ley, T. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.010 · Cited by 452 · see citing works

Chemokines and T Lymphocytes

Ward, S. G., Bacon, K. B., & Westwick, J. K. (1998) · Immunity · doi:10.1016/s1074-7613(00)80583-x · Cited by 394 · see citing works

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

Metkar, S. S., Menaa, C., Pardo, J., Wang, B., Wallich, R., Freudenberg, M. A., Kim, S. H., Raja, S. M., Shi, L. F., Simon, M. M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.014 · Cited by 304 · see citing works

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

Afonina, I. S., Tynan, G. A., Logue, S. E., Cullen, S. P., Bots, M. L., Lüthi, A. U., Reeves, E. P., McElvaney, N. G., Medema, J. P., Lavelle, E. C., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.037 · Cited by 275 · see citing works

To kill or to cure: options in host defense against viral infection

Guidotti, L. G., & Chisari, F. V. (1996) · Current Opinion in Immunology · doi:10.1016/s0952-7915(96)80034-3 · Cited by 266 · see citing works

T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?

Zinkernagel, R. M., Haenseler, E., Leist, T., Cerny, A., Hengartner, H., & Althage, A. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.164.4.1075 · Cited by 208 · see citing works

MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection

Zhou, S.-H., Kurt-Jones, E., Mandell, L., Cerny, A. M., Chan, M., Golenbock, D., & Finberg, R. (2005) · European Journal of Immunology · doi:10.1002/eji.200425730 · Cited by 169 · see citing works

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

Pardo, J., Bosque, A., Brehm, R., Wallich, R., Naval, J., Müllbacher, A., Anel, A., & Simon, M. M. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200406115 · Cited by 157 · see citing works

Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin

Pardo, J., Wallich, R., Ebnet, K., et al. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402183 · Cited by 137 · see citing works

Mechanisms of Liver Cell Injury in Acute and Chronic Hepatitis B

Mondelli, M. U., & Eddleston, A. L. W. F. (1984) · Seminars in Liver Disease · doi:10.1055/s-2008-1040645 · Cited by 118 · see citing works

The genes for perforin, granzymes A–C and IFN‐γ are differentially expressed in single CD8+ T cells during primary activation

Kelso, A., Costelloe, E. O., Johnson, B. J. B., et al. (2002) · International Immunology · doi:10.1093/intimm/dxf028 · Cited by 108 · see citing works

Mouse granzyme K has pro-inflammatory potential

Joeckel, L. T., Wallich, R., Martin, P., Sánchez‐Martínez, D., Weber, F. C., Martin, S. F., Borner, C., Pardo, J., Froelich, C. J., & Simon, M. M. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.5 · Cited by 106 · see citing works

Granzyme B and the Downstream Granzymes C and/or F Are Important for Cytotoxic Lymphocyte Functions

Revell, P. A., Grossman, W. J., Thomas, D. A., Cao, X., Behl, R., Ratner, J. A., Lu, Z. H., & Ley, T. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2124 · Cited by 106 · see citing works

Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus

Bruno, R., Sabater, L., Sospedra, M., Ferrer-Francesch, X., Escudero, D., Martínez-Cáceres, E. M., & Pujol‐Borrell, R. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(2002010)32:10 · Cited by 102 · see citing works

Heterogeneity of Effector Phenotype for Acute Phase and Memory Influenza A Virus-Specific CTL

Jenkins, M. R., Kedzierska, K., Doherty, P. C., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.64 · Cited by 91 · see citing works

Signal 3 Tolerant CD8 T Cells Degranulate in Response to Antigen but Lack Granzyme B to Mediate Cytolysis

Curtsinger, J. M., Lins, D. C., Johnson, C. M., & Mescher, M. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4392 · Cited by 90 · see citing works

Concerted Action of the FasL/Fas and Perforin/Granzyme A and B Pathways Is Mandatory for the Development of Early Viral Hepatitis but Not for Recovery from Viral Infection

Balkow, S., Kersten, A., Tran, T. T. T., Stehlé, T., Grosse, P., Muşeţeanu, C., Utermöhlen, O., Pircher, H., von Weizsäcker, F., Wallich, R., et al. (2001) · Journal of Virology · doi:10.1128/jvi.75.18.8781-8791.2001 · Cited by 88 · see citing works

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

Anthony, D. A., Andrews, D. M., Chow, M. B., Watt, S. V., House, C. M., Akira, S., Bird, P. I., Trapani, J. A., & Smyth, M. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000430 · Cited by 88 · see citing works

Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs

Pardo, J., Wallich, R., Martin, P., et al. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402289 · Cited by 85 · see citing works

Molecular and cellular pathology of hepatitis B.

Gerber, M. A., & Sn, T. (1985) · PubMed · Cited by 75 · see citing works

Cutting Edge: IL-1 Controls the IL-23 Response Induced by Gliadin, the Etiologic Agent in Celiac Disease

Harris, K. M., Fasano, A., & Mann, D. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4457 · Cited by 70 · see citing works

T Cell Responses to Viral Infections: Lessons from Lymphocytic Choriomeningitis Virus

Khanolkar, A., Fuller, M. J., & Zajac, A. J. (2002) · Immunologic Research · doi:10.1385/ir:26:1-3:309 · Cited by 55 · see citing works

Perforin Rapidly Induces Plasma Membrane Phospholipid Flip-Flop

Metkar, S. S., Wang, B., Catalán, E., Anderluh, G., Gilbert, R. J. C., Pardo, J., & Froelich, C. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024286 · Cited by 48 · see citing works

Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

Kurschus, F. C., Fellows, E., Stegmann, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801724105 · Cited by 48 · see citing works

Differential Expression of Granzyme B and C in Murine Cytotoxic Lymphocytes

Cai, S. F., Fehniger, T. A., Cao, X., Mayer, J. C., Brune, J. D., French, A. R., & Ley, T. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804333 · Cited by 44 · see citing works

IRAK‐4 kinase activity is required for IRAK‐4‐dependent innate and adaptive immune responses

Lye, E., Dhanji, S., Calzascia, T., Elford, A. R., & Ohashi, P. S. (2008) · European Journal of Immunology · doi:10.1002/eji.200737429 · Cited by 43 · see citing works

Breakdown of blood-brain barrier function in the murine lymphocytic choriomeningitis virus infection mediated by virus-specific CD8+ T cells

Andersen, I., Marker, O., & Thomsen, A. R. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90021-x · Cited by 43 · see citing works

A suspenseful game of 'hide and seek' between virus and host

Oldstone, M. B. A. (2007) · Nature Immunology · doi:10.1038/ni0407-325 · Cited by 29 · see citing works

Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?

Martin, P., Wallich, R., Pardo, J., et al. (2005) · Blood · doi:10.1182/blood-2005-04-1522 · Cited by 29 · see citing works

Perforin and Fas Act Together in the Induction of Apoptosis, and Both Are Critical in the Clearance of Lymphocytic Choriomeningitis Virus Infection

Rode, M., Balkow, S., Sobek, V., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.22.12395-12405.2004 · Cited by 27 · see citing works

T-cell intrinsic expression of MyD88 is required for sustained expansion of the virus-specific CD8+ T-cell population in LCMV-infected mice

Bartholdy, C., Christensen, J. E., Grujić, M., et al. (2009) · Journal of General Virology · doi:10.1099/vir.0.004960-0 · Cited by 27 · see citing works

Granzyme B-induced and Caspase 3-dependent Cleavage of Gelsolin by Mouse Cytotoxic T Cells Modifies Cytoskeleton Dynamics

Martin, P., Pardo, J., Schill, N., Joeckel, L. T., Berg, M., Froelich, C. J., Wallich, R., & Simon, M. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056028 · Cited by 18 · see citing works

The interleukin-1 family: back to the future

Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945 · see citing works

TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling

Kumar, S. R. P., Biswas, M., Cao, D., Arisa, S., Muñoz-Melero, M., Lam, A. K., Piñeros, A. R., Kapur, R., Kaisho, T., Kaufman, R. J., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2023.11.029 · Cited by 31 · see citing works

Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain

Xing, J., Chai, Z., Ly, H., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01674-15 · Cited by 35 · see citing works

Complete sequence of the S RNA of lymphocytic choriomeningitis virus (WE strain) compared to that of pichinde arenavirus

Romanowski, V., Matsuura, Y., & Bishop, D. H. L. (1985) · Virus Research · doi:10.1016/0168-1702(85)90001-2 · Cited by 101 · see citing works

Novel Arenavirus Infection in Humans, United States

Milazzo, M. L. (2011) · Emerging infectious diseases · doi:10.3201/eid1708.110285 · Cited by 27 · see citing works

Visualizing lymphocytic choriomeningitis virus infection in cells and living mice

Wen, Y., Xu, H., Wan, W., Shang, W., Jin, R., Zhou, F., Mei, H., Wang, J., Xiao, G., Chen, H., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105090 · Cited by 13 · see citing works

Conserved sequences and coding of two strains of lymphocytic choriomeningitis virus (WE and ARM) and Pichinde arenavirus

Romanowski, V., & Bishop, D. H. L. (1985) · Virus Research · doi:10.1016/0168-1702(85)90058-9 · Cited by 53 · see citing works