Anti-inflammatory Agents: Present and Future

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674 · see citing works

Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein

Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J. J., Gotto, A. M., Kastelein, J. J. P., Köenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000344393.60303.0a · Cited by 3,641 · see citing works

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works

Biologic basis for interleukin-1 in disease.

Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 3,380 · see citing works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354 · see citing works

The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

Endres, S., Ghorbani, R., Kelley, V. E., Georgilis, K., Lonnemann, G., van der Meer, J. W. M., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902023200501 · Cited by 1,898 · see citing works

Histone deacetylases and cancer: causes and therapies

Marks, P. A., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., & Kelly, W. K. (2001) · Nature reviews. Cancer · doi:10.1038/35106079 · Cited by 1,866 · see citing works

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679 · see citing works

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Figari, I. S., Palladino, M. A., & O'Connor, J. V. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.6.1433 · Cited by 1,472 · see citing works

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.

Sampaio, E. P., Sarno, E. N., Gallily, R., Cohn, Z. A., & Kaplan, G. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.3.699 · Cited by 1,191 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92172 · Cited by 1,114 · see citing works

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

Masters, S. L., Simon, A., Aksentijevich, I. A., & Kastner, D. L. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141627 · Cited by 1,063 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215318 · Cited by 1,006 · see citing works

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

Aksentijevich, I. A., Masters, S. L., Ferguson, P. J., Dancey, P., Frenkel, J., van Royen‐Kerkhof, A., Laxer, R. M., Tedgård, U., Cowen, E. W., Pham, T., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807865 · Cited by 981 · see citing works

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Goldbach‐Mansky, R. T., Garnes, N. D., Canna, S., Gelabert, A., Jones, J. H., Rubin, B. I., Kim, H. J., Brewer, C. C., Zalewski, C. K., Wiggs, E. A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055137 · Cited by 923 · see citing works

Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

Pascual, V., Allantaz, F., Arce, E., Punaro, M., & Banchereau, J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050473 · Cited by 923 · see citing works

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 922 · see citing works

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

Lachmann, H. J., Kone-Paut, I., Kuemmerle-Deschner, J. B., Leslie, K. S., Hachulla, E., Quartier, P., Gitton, X., Widmer, A., Patel, N., & Hawkins, P. N. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810787 · Cited by 869 · see citing works

Rapid Secretion of Interleukin-1β by Microvesicle Shedding

Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862 · see citing works

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

Hockly, E., Richon, V. M., Woodman, B., Smith, D. L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi‐Noori, S., Mahal, A., Lowden, P. A. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437870100 · Cited by 847 · see citing works

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

Horai, R., Saijo, S., Tanioka, H., Nakae, S., Sudo, K., Okahara, A., Ikuse, T., Asano, M., & Iwakura, Y. (2000) · Journal of Experimental Medicine · doi:10.1084/jem.191.2.313 · Cited by 792 · see citing works

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

Netea, M. G., Nold‐Petry, C. A., Nold, M. F., Joosten, L. A. B., Opitz, B., van der Meer, J. H. M., van de Veerdonk, F. L., Ferwerda, G., Heinhuis, B., Devesa, I., et al. (2008) · Blood · doi:10.1182/blood-2008-03-146720 · Cited by 787 · see citing works

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

Krishnamoorthy, S., Recchiuti, A., Chiang, N., Yacoubian, S., Lee, C., Yang, R., Petasis, N. A., & Serhan, C. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907342107 · Cited by 738 · see citing works

A pilot study of IL-1 inhibition by anakinra in acute gout

So, A., De Smedt, T., Revaz, S., & Tschopp, J. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2143 · Cited by 727 · see citing works

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Khan, N., Jeffers, M., Kumar, S., Hackett, C., Boldog, F., Khramtsov, N., Qian, X., Mills, E., Berghs, S. C., Carey, N., et al. (2008) · Biochemical Journal · doi:10.1042/bj20070779 · Cited by 713 · see citing works

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

Stienstra, R., Joosten, L. A. B., Koenen, T. B., van Tits, B. L. J. H., van Diepen, J. A., van den Berg, S. A. A., Rensen, P. C. N., Voshol, P. J., Fantuzzi, G., Hijmans, A., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.011 · Cited by 681 · see citing works

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

Fong, Y., Tracey, K. J., Moldawer, L. L., HESSE, D. G., Manogue, K., Kenney, J. S., Lee, A. T., Kuo, G. C., ALLISON, A. C., & Lowry, S. F. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.5.1627 · Cited by 640 · see citing works

Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

Charles, P., Elliott, M. J., Davis, D., Potter, A., Kalden, J., Antoni, C., Breedveld, F., Smolen, J., Eberl, G., Dewoody, K., et al. (1999) · Journal of Immunology · doi:10.4049/jimmunol.163.3.1521 · Cited by 614 · see citing works

Efficacy and safety of rilonacept (interleukin‐1 trap) in patients with cryopyrin‐associated periodic syndromes: Results from two sequential placebo‐controlled studies

Hoffman, H. M., Throne, M. L., Amar, N. J., Sebai, M., Kivitz, A. J., Kavanaugh, A., Weinstein, S. P., Belomestnov, P., Yancopoulos, G. D., Stahl, N., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23687 · Cited by 577 · see citing works

Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages

Qu, Y., Franchi, L., Nunez, G., & Dubyak, G. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1913 · Cited by 563 · see citing works

Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome

Drenth, J. P. H., Cuisset, L., Grateau, G., Vasseur, C., van der Velde-Visser, S. D., de Jong, J. G. N., Beckmann, J. S., van der Meer, J. W. M., & Delpech, M. (1999) · Nature Genetics · doi:10.1038/9696 · Cited by 556 · see citing works

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

Hoffman, H. M., Rosengren, S., Boyle, D. L., Cho, J. Y., Nayar, J., Mueller, J. L., Anderson, J. P., Wanderer, A. A., & Firestein, G. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17401-1 · Cited by 552 · see citing works

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double‐blind, placebo‐controlled study

Chevalier, X., Goupille, P., Beaulieu, A. D., Burch, F. X., Bensen, W., Conrozier, T., Lœuille, D., Kivitz, A., Silver, D., & Appleton, B. E. (2009) · Arthritis Care & Research · doi:10.1002/art.24096 · Cited by 538 · see citing works

Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

Dinarello, C. A., Ikejima, T., Warner, S. J. C., Orencole, S. F., Lonnemann, G., Cannon, J. G., & Libby, P. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.6.1902 · Cited by 537 · see citing works

Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

Charles, P. J., Elliott, M. J., Davis, D., Potter, A. R., Kalden, J. R., Antoni, C., Breedveld, F. C., Js, S., Eberl, G., DeWoody, K. L., et al. (1999) · PubMed · Cited by 531 · see citing works

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

Leoni, F., Zaliani, A., Bertolini, G., Porro, G., Pagani, P., Pozzi, P., Donà, G., Fossati, G., Sozzani, S., Azam, T., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052702999 · Cited by 511 · see citing works

Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes

Garcia‐Manero, G., Yang, H., Bueso-Ramos, C., Ferrajoli, A., Cortes, J. E., Wierda, W. G., Faderl, S. H., Koller, C. A., Morris, G., Rosner, G. L., et al. (2007) · Blood · doi:10.1182/blood-2007-06-098061 · Cited by 460 · see citing works

A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

Emsley, H. C. A. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054882 · Cited by 444 · see citing works

Progressive Multifocal Leukoencephalopathy in Patients on Immunomodulatory Therapies

Major, E. O. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.080708.082655 · Cited by 437 · see citing works

Endogenous pro‐resolving and anti‐inflammatory lipid mediators: a new pharmacologic genus

Serhan, C. N., & Chiang, N. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707489 · Cited by 428 · see citing works

Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

Abbate, A., Kontos, M. C., Grizzard, J. D., Biondi‐Zoccai, G., Tassell, B. W. V., Robati, R., Roach, L. M., Arena, R. A., Roberts, C. S., Varma, A., et al. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.12.059 · Cited by 418 · see citing works

Phospholipases C and A 2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes

Andrei, C., Margiocco, P., Poggi, A. D., Lotti, L. V., Torrisi, M. R., & Rubartelli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308558101 · Cited by 409 · see citing works

An Autoinflammatory Disease Due to Homozygous Deletion of the IL1RN Locus

Reddy, S. T., Jia, S., Geoffrey, R., Lorier, R., Suchi, M., Broeckel, U., Hessner, M. J., & Verbsky, J. W. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0809568 · Cited by 408 · see citing works

Clinical Experience With Intravenous and Oral Formulations of the Novel Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid in Patients With Advanced Hematologic Malignancies

O’Connor, O. A., Heaney, M. L., Schwartz, L. B., Richardson, S., Willim, R. D., MacGregor‐Cortelli, B., Curly, T., Moskowitz, C. H., Portlock, C. S., Horwitz, S. M., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.9679 · Cited by 404 · see citing works

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes

Larsen, C. M., Faulenbach, M., Vaag, A., Ehses, J. A., Donath, M. Y., & Mandrup-Poulsen, T. (2009) · Diabetes Care · doi:10.2337/dc09-0533 · Cited by 401 · see citing works

Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

Ren, M., Leng, Y., Jeong, M. R., Leeds, P. R., & Chuang, D. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02406.x · Cited by 378 · see citing works

Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

Coeshott, C. M., Ohnemus, C., Pilyavskaya, A., Ross, S., Wieczorek, M., Kroona, H., Leimer, A. H., & Cheronis, J. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6261 · Cited by 365 · see citing works

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

Abbate, A., Salloum, F. N., Vecile, E., Das, A., Hoke, N. N., Straino, S., Biondi‐Zoccai, G., Houser, J.-E., Qureshi, I. Z., Ownby, E. D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.740233 · Cited by 359 · see citing works

Rapid responses to anakinra in patients with refractory adult‐onset Still's disease

Fitzgerald, A. A., LECLERCQ, S. A., Yan, A., Homik, J., & Dinarello, C. A. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21061 · Cited by 349 · see citing works

Treatment of rheumatoid arthritis with a syk kinase inhibitor: A twelve‐week, randomized, placebo‐controlled trial

Weinblatt, M. E., Kavanaugh, A., Burgos‐Vargas, R., Dikranian, A. H., Medrano-Ramírez, G., Morales‐Torres, J., Murphy, F. T., Musser, T. K., Straniero, N., Vicente‐Gonzales, A. V., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23992 · Cited by 343 · see citing works

Risk and the Efficacy of Antiinflammatory Agents: Retrospective and Confirmatory Studies of Sepsis

Eichacker, P. Q., Parent, C., Kalil, A. C., Esposito, C., Cui, X., Banks, S. M., Gerstenberger, E. P., Fitz, Y., Danner, R. L., & Natanson, C. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200204-302oc · Cited by 340 · see citing works

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release

Kahlenberg, J. M., & Dubyak, G. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00494.2003 · Cited by 337 · see citing works

The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo

Leoni, F., Fossati, G., Lewis, E. C., Lee, J.-K., Porro, G., Pagani, P., Modena, D., Moras, M. L., Pozzi, P., Reznikov, L. L., et al. (2005) · Molecular Medicine · doi:10.2119/2006-00005.dinarello · Cited by 337 · see citing works

Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans

Mandrup-Poulsen, T. R., Bendtzen, K., Nerup, J., Dinarello, C. A., Svenson, M., & Nielsen, J. H. (1986) · Diabetologia · doi:10.1007/bf02427283 · Cited by 324 · see citing works

Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene

Nicklin, M. J. H., Hughes, D. E., Barton, J. L., Ure, J. M., & Duff, G. W. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.2.303 · Cited by 319 · see citing works

Caspase 1–independent activation of interleukin‐1β in neutrophil‐predominant inflammation

Gumá, M., Ronacher, L., Liu‐Bryan, R., Takai, S., Karin, M., & Corr, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24959 · Cited by 305 · see citing works

The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study

Terkeltaub, R. A., Sundy, J. S., Schumacher, H. R., Murphy, F. T., Bookbinder, S., Biedermann, S., Wu, R., Mellis, S. J., & Radin, A. R. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.108936 · Cited by 297 · see citing works

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin‐1β

Joosten, L. A. B., Netea, M. G., Fantuzzi, G., Koenders, M. I., Helsen, M. M. A., Sparrer, H., Pham, C. T. N., van der Meer, J. W. M., Dinarello, C. A., & van den Berg, W. B. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25006 · Cited by 296 · see citing works

Interleukin-1β–Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen–Induced Tumors

Krelin, Y., Voronov, E., Dotan, S., Elkabets, M., Reich, E., Fogel, M., Huszar, M., Iwakura, Y., Segal, S., Dinarello, C. A., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2956 · Cited by 285 · see citing works

Osmotic regulation of cytokine synthesis in vitro.

Shapiro, L., & Dinarello, C. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12230 · Cited by 280 · see citing works

Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death

Brough, D., & Rothwell, N. J. (2007) · Journal of Cell Science · doi:10.1242/jcs.03377 · Cited by 265 · see citing works

Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide

Münch, J., Ständker, L., Adermann, K., Schulz, A., Schindler, M., Chinnadurai, R., Pöhlmann, S., Chaipan, C., Biet, T., Peters, T., et al. (2007) · Cell · doi:10.1016/j.cell.2007.02.042 · Cited by 261 · see citing works

ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1β and IL-18 in Human Blood

Perregaux, D. G., McNiff, P. A., Laliberte, R., Conklyn, M. J., & Gabel, C. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4615 · Cited by 256 · see citing works

Inflammation and the Activated Protein C Anticoagulant Pathway

Esmon, C. T. (2006) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2006-939554 · Cited by 248 · see citing works

Pattern of interleukin‐1β secretion in response to lipopolysaccharide and ATP before and after interleukin‐1 blockade in patients with CIAS1 mutations

Gattorno, M., Tassi, S., Carta, S., Delfino, L., Ferlito, F., Pelagatti, M. A., D’Osualdo, A., Buoncompagni, A., Alpigiani, M. G., Alessio, M., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22842 · Cited by 247 · see citing works

Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1β-Induced Interleukin 6 Production and the Myeloma Proliferative Component

Lust, J. A., Lacy, M. Q., Zeldenrust, S. R., Dispenzieri, A. A., Gertz, M. A., Witzig, T. E., Kumar, S. K., Hayman, S. R., Russell, S. J., Buadi, F. K., et al. (2009) · Mayo Clinic Proceedings · doi:10.4065/84.2.114 · Cited by 246 · see citing works

Response to local inflammation of IL-1 beta-converting enzyme- deficient mice

Fantuzzi, G., Ku, G., Harding, M. W., Livingston, D. J., Sipe, J. D., Kuida, K., Flavell, R. A., & Dinarello, C. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1818 · Cited by 232 · see citing works

Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra

Brenner, M., Ruzicka, T., Plewig, G., Thomas, P., & Herzer, P. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09404.x · Cited by 225 · see citing works

Interleukin-1β and the Autoinflammatory Diseases

Dinarello, C. A. (2009) · New England Journal of Medicine · doi:10.1056/nejme0811014 · Cited by 224 · see citing works

Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis

Paniagua, R. T., Sharpe, O., Ho, P. P.-K., Chan, S. M., Chang, A., Higgins, J. P., Tomooka, B. H., Thomas, F. M., Song, J. J., Goodman, S. B., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28546 · Cited by 220 · see citing works

IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients

Stack, J. H., Beaumont, K. C., Larsen, P. D., Straley, K. S., Henkel, G., Randle, J. C. R., & Hoffman, H. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2630 · Cited by 191 · see citing works

α1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice

Lewis, E. C., Mizrahi, M. I., Toledano, M., DeFelice, N., Wright, J. L., Churg, A., Shapiro, L., & Dinarello, C. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807627105 · Cited by 188 · see citing works

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

Archin, N. M., Eron, J. J., Palmer, S., Hartmann-Duff, A., Martinson, J., Wiegand, A. P., Bandarenko, N., Schmitz, J. L., Bosch, R. J., LANDAY, A. L., et al. (2008) · AIDS · doi:10.1097/qad.0b013e3282fd6df4 · Cited by 186 · see citing works

α-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood

Pott, G. B., Chan, E. D., Dinarello, C. A., & Shapiro, L. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208145 · Cited by 185 · see citing works

Effect of etanercept and anakinra on inflammatory attacks in the hyper-IgD syndrome: introducing a vaccination provocation model.

Bodar, E. J., van der Hilst, J. C. H., Drenth, J. P. H., van der Meer, J. W. M., & Simon, A. (2005) · PubMed · Cited by 166 · see citing works

Prostaglandin I2 Analogs Inhibit Proinflammatory Cytokine Production and T Cell Stimulatory Function of Dendritic Cells

Zhou, W., Hashimoto, K., Goleniewska, K., O’Neal, J. F., Ji, S., Blackwell, T. S., FitzGerald, G. A., Egan, K. M., Geraci, M. W., & Peebles, R. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.702 · Cited by 165 · see citing works

Beneficial response to interleukin 1 receptor antagonist in traps

Simon, A., Bodar, E. J., van der Hilst, J. C. H., van der Meer, J. W. M., Fiselier, T. J. W., Cuppen, M. P. J. M., & Drenth, J. P. H. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.02.039 · Cited by 164 · see citing works

Alpha‐1‐antitrypsin inhibits human immunodeficiency virus type 1

Shapiro, L., Pott, G. B., & Ralston, A. H. (2001) · The FASEB Journal · doi:10.1096/fj.00-0311com · Cited by 163 · see citing works

Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis.

Ferretti, M., Casini–Raggi, V., Pizarro, T. T., Eisenberg, S. P., Nast, C. C., & Cominelli, F. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117345 · Cited by 154 · see citing works

The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2V617F

Guerini, V., Barbui, V., Spinelli, O., Salvi, A., Dellacasa, C. M., Carobbio, A., Introna, M., Barbui, T., Golay, J., & Rambaldi, A. (2007) · Leukemia · doi:10.1038/sj.leu.2405049 · Cited by 153 · see citing works

Statins as antiinflammatory and immunomodulatory agents: A future in rheumatologic therapy?

Abeles, A. M., & Pillinger, M. H. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21521 · Cited by 149 · see citing works

A case of macrophage activation syndrome successfully treated with anakinra

Kelly, A., & Ramanan, A. V. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0919 · Cited by 147 · see citing works

Anti-angiogenesis Effect of the Novel Anti-inflammatory and Pro-resolving Lipid Mediators

Jin, Y., Arita, M., Zhang, Q., Saban, D. R., Chauhan, S. K., Chiang, N., Serhan, C. N., & Dana, R. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2462 · Cited by 144 · see citing works

ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization

Laliberte, R. E., Eggler, J. F., & Gabel, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.36944 · Cited by 138 · see citing works

HMG-CoA reductase inhibition induces IL-1β release through Rac1/PI3K/PKB-dependent caspase-1 activation

Kuijk, L. M., Beekman, J. M., Koster, J., Waterham, H. R., Frenkel, J., & Coffer, P. J. (2008) · Blood · doi:10.1182/blood-2008-03-144667 · Cited by 138 · see citing works

A Novel Targeted Inhibitor of the Alternative Pathway of Complement and Its Therapeutic Application in Ischemia/Reperfusion Injury

Huang, Y., Qiao, F., Atkinson, C., Holers, V. M., & Tomlinson, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.8068 · Cited by 133 · see citing works

Histone Deacetylase Inhibitors: Molecular and Biological Activity as a Premise to Clinical Application

Santini, V., Gozzini, A., & Ferrari, G. (2007) · Current Drug Metabolism · doi:10.2174/138920007780655397 · Cited by 131 · see citing works

Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

Larsen, L. H., Tonnesen, M., Rønn, S. G., Størling, J., Jørgensen, S. W., Mascagni, P., Dinarello, C. A., Billestrup, N., & Mandrup-Poulsen, T. R. (2007) · Diabetologia · doi:10.1007/s00125-006-0562-3 · Cited by 131 · see citing works

Statins differ in their ability to block NF-kB activation in human blood monocytes

Hilgendorff, A., Muth, H., Parviz, B., Staubitz, A., Haberbosch, W., Tillmanns, H., & Hölschermann, H. (2003) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp41397 · Cited by 130 · see citing works

The kinase inhibitor imatinib mesylate inhibits TNF-α production in vitro and prevents TNF-dependent acute hepatic inflammation

Wolf, A. M., Wolf, D. G. F., Rumpold, H. F., Ludwiczek, S., Enrich, B., Gastl, G. A., Weiß, G., & Tilg, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501758102 · Cited by 124 · see citing works

Oral High-Dose Atorvastatin Treatment in Relapsing-Remitting Multiple Sclerosis

Paul, F., Waiczies, S., Wuerfel, J. T., Bellmann–Strobl, J., Dörr, J. R., Waiczies, H., Haertle, M., Wernecke, K. D., Volk, H., Aktaş, O., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001928 · Cited by 121 · see citing works

Oral valproic acid for epilepsy - long-term experience in therapy and side effects

Gerstner, T. A., Bell, N. V. T., & König, S. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.2.285 · Cited by 115 · see citing works

Anti-chemokine small molecule drugs: a promising future?

Proudfoot, A. E. J., Power, C., & Schwarz, M. K. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903535867 · Cited by 107 · see citing works

Pioglitazone Inhibits Toll-Like Receptor Expression and Activity in Human Monocytes and db/db Mice

Dasu, M. R. K., Park, S., Devaraj, S., & Jialal, I. (2007) · Endocrinology · doi:10.1210/en.2008-1757 · Cited by 103 · see citing works

The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment

Marin, V., Farnarier, C., Grès, S., Kaplanski, S., Su, M. S. S., Dinarello, C. A., & Kaplanski, G. (2001) · Blood · doi:10.1182/blood.v98.3.667 · Cited by 102 · see citing works

Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury

Shein, N. A., Grigoriadis, N., Alexandrovich, A. G., Simeonidou, C., Lourbopoulos, A. I., Polyzoidou, E., Trembovler, V., Mascagni, P., Dinarello, C. A., & Shohami, E. (2009) · The FASEB Journal · doi:10.1096/fj.09-134700 · Cited by 98 · see citing works

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels

Rafiq, S., Stevens, K., Hurst, A. J., Murray, A., Henley, W., Weedon, M. N., Bandinelli, S., Corsi, A. M., Guralnik, J. M., Ferruci, L., et al. (2007) · Genes & Immunity · doi:10.1038/sj.gene.6364393 · Cited by 92 · see citing works

Pexelizumab in ischemic heart disease: A systematic review and meta-analysis on 15,196 patients

Testa, L., van Gaal, W. J., Bhindi, R., Biondi‐Zoccai, G., Abbate, A., Agostoni, P., Porto, I., Andreotti, F., Crea, F., & BANNING, A. P. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.12.062 · Cited by 83 · see citing works

Bypassing Pathogen‐Induced Inflammasome Activation for the Regulation of Interleukin‐1β Production by the Fungal PathogenCandida albicans

van de Veerdonk, F. L., Joosten, L. A. B., Devesa, I., Mora-Montes, H. M., Kanneganti, T., Dinarello, C. A., van der Meer, J. W. M., Gow, N. A. R., Kullberg, B. J., & Netea, M. G. (2009) · The Journal of Infectious Diseases · doi:10.1086/597274 · Cited by 77 · see citing works

Schnitzler syndrome: Treatment failure to rituximab but response to anakinra

Eiling, E., Möller, M., Kreiselmaier, I., Brasch, J., & Schwarz, T. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.03.036 · Cited by 75 · see citing works

Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment.

Dinarello, C. A. (2005) · PubMed · Cited by 73 · see citing works

Anakinra suppresses familial Mediterranean fever crises in a colchicine-resistant patient.

Mitroulis, I., Papadopoulos, V. P., Konstantinidis, T. G., & Ritis, K. (2008) · PubMed · Cited by 66 · see citing works

Pharmacologic induction of fetal hemoglobin: raising the therapeutic bar in sickle cell disease

Atweh, G. F., & Schechter, A. N. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200103000-00010 · Cited by 66 · see citing works

The controversial effects of thiazolidinediones on cardiovascular morbidity and mortality

Stafylas, P. C., Sarafidis, P. A., & Lasaridis, A. N. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.06.005 · Cited by 64 · see citing works

The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Improves Cardiometabolic Risk and Renal Inflammation in Murine Lupus

Zhao, W., Thacker, S. G., Hodgin, J. B., Zhang, H., Wang, J. H., Park, J. L., Randolph, A. E., Somers, E. C., Pennathur, S., Kretzler, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804341 · Cited by 58 · see citing works

Converting enzyme-independent release of tumor necrosis factor a and IL-1b from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3 (neutrophil elastaseycytokine processingyproteinase inhibitors)

Coeshott, C. M., Pilyavskaya, A., Ross, S., Wieczorek, M., Kroona, H., Leimer, A. H., & Cheronis, J. C. (1999) · Cited by 57 · see citing works

Antisynthetase syndrome with refractory polyarthritis and fever successfully treated with the IL-1 receptor antagonist, anakinra: A case report

Furlan, A., Botsios, C., Ruffatti, A., TODESCO, S., & Punzi, L. (2008) · Joint Bone Spine · doi:10.1016/j.jbspin.2007.07.010 · Cited by 53 · see citing works

Complete remission of severe idiopathic cold urticaria on interleukin-1 receptor antagonist (anakinra).

Bodar, E. J., Simon, A., de Visser, M., & van der Meer, J. W. M. (2009) · PubMed · Cited by 51 · see citing works

Human Mitogen-activated Protein Kinase CSBP1, but Not CSBP2, Complements a hog1 Deletion in Yeast

Kumar, S., McLaughlin, M. M., McDonnell, P., Lee, J. C., Livi, G. P., & Young, P. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29043 · Cited by 50 · see citing works

Rab39a Binds Caspase-1 and Is Required for Caspase-1-dependent Interleukin-1β Secretion

Becker, C., Creagh, E. M., & O'Neill, L. A. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046102 · Cited by 49 · see citing works

Searching for Disease Modifiers—PKC Activation and HDAC Inhibition—A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress

Kozikowski, A. P., Chen, Y., Tapadar, S., Lewin, N. E., Blumberg, P. M., Zhong, Z., D’Annibale, M. A., Wang, W., Shen, Y., & Langley, B. C. (2009) · ChemMedChem · doi:10.1002/cmdc.200900045 · Cited by 43 · see citing works

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

Stienstra, R., Joosten, L. A. B., Koenen, T. B., van der Meer, J. W. M., Tack, C. J., Kanneganti, T., & Netea, M. G. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.567 · Cited by 41 · see citing works

Non‐complementaemic urticarial vasculitis: successful treatment with the IL‐1 receptor antagonist, anakinra

Botsios, C., Sfriso, P., Punzi, L., & TODESCO, S. (2007) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740600938647 · Cited by 37 · see citing works

Variations in the interleukin-1 receptor antagonist gene impact on survival of patients with advanced colorectal cancer

Graziano, F., Ruzzo, A., Canestrari, E., Loupakis, F., Santini, D., Rulli, E., Humar, B., Galluccio, N., Bisonni, R., Floriani, I., et al. (2008) · The Pharmacogenomics Journal · doi:10.1038/tpj.2008.16 · Cited by 31 · see citing works

Islets of Langerhans

Bauer, G. E. (1983) · doi:10.1007/978-1-349-06859-3_22 · Cited by 27 · see citing works

The Complement Inhibitor FUT-175 Suppresses T Cell Autoreactivity in Experimental Autoimmune Encephalomyelitis

Li, Q., Nacion, K. M., Bu, H., & Lin, F. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081093 · Cited by 25 · see citing works

Indications de l’anakinra

Chauffier, K., London, J., Beaudouin, C., & Fautrel, B. (2009) · La Presse Médicale · doi:10.1016/j.lpm.2009.01.012 · Cited by 21 · see citing works

Regulatory roles for histone deacetylation in IL‐1β‐induced nitric oxide release in pancreatic β‐cells

Susick, L. L., Veluthakal, R., Suresh, M. V., Hadden, T. J., & Kowluru, A. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00171.x · Cited by 19 · see citing works

Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in-vivo model of septic shock

Nold‐Petry, C. A., Fischer, D., Richter, B., Blaheta, R. A., Pfeilschifter, J. M., Mühl, H., Schranz, D., Veldman, A., & Nold, M. F. (2007) · Thrombosis and Haemostasis · doi:10.1160/th07-01-0052 · Cited by 18 · see citing works

Lenalidomide and its role in the management of multiple myeloma

Falco, P., Cavallo, F., Larocca, A., Liberati, A. M., Musto, P., Boccadoro, M., & Palumbo, A. (2008) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.8.6.865 · Cited by 16 · see citing works

Cytokine modulation and suppression of liver injury by a novel analogue of thalidomide

Thiele, A., Bang, R., Gütschow, M., Rossol, M., Loos, S., Eger, K., Tiegs, G., & Hauschildt, S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02423-8 · Cited by 13 · see citing works

Expression and localization of IL‐1β mRNA is interrelated with cytoskeletal rearrangement in monocytes stimulated by adherence: A light microscopy in situ hybridization study

Böcker, U., Sirenko, O. I., Morris, J., Sartor, R. B., Singer, M., Haskill, J. S., & Watson, J. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.01031.x · Cited by 12 · see citing works

Safety and efficacy of oral ITF2357 in patients with active systemic onset juvenile idiopathic arthritis

Vojinović, J., Dinarello, C. A., Furlan, A., Damjanov, N. S., D’Urzo, C., & Oldoni, T. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.391 · Cited by 7 · see citing works

Decreased whole blood cytokine production during a phase I trial of the histone deacetylase inhibitor ITF2357

Oldoni, T., Furlan, A., Monzani, M. V., & Dinarello, C. A. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.506 · Cited by 4 · see citing works

The anti-CD20 antibody Rituximab reduces the Th17 response

van de Veerdonk, F. L., Lauwerys, B., DiPadova, F., Marijnissen, R. J., Koenders, M. I., Gutierrez-Roelens, I., Durez, P., Netea, M. G., van der Meer, J. W. M., van den Berg, W. B., et al. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.412 · Cited by 1 · see citing works

Inflammation and tumor progression: signaling pathways and targeted intervention

Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., & Li, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00658-5 · Cited by 2,907 · see citing works

The interleukin-1 family: back to the future

Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945 · see citing works

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

Dinarello, C., Simon, A., & van der Meer, J. V. D. (2012) · Nature reviews. Drug discovery · doi:10.1038/nrd3800 · Cited by 1,813 · see citing works

Understanding the mechanism of IL-1β secretion

Lopez-Castejon, G., & Brough, D. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.10.001 · Cited by 1,519 · see citing works

The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives

Tsalamandris, S., Antonopoulos, A. S., Oikonomou, E., Papamikroulis, G.-A., Vogiatzi, G., Papaioannou, S., Deftereos, S., & Tousoulis, D. (2019) · European Cardiology Review · doi:10.15420/ecr.2018.33.1 · Cited by 1,381 · see citing works

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works

Compromised MAPK signaling in human diseases: an update

Kim, E., & Choi, E. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1472-2 · Cited by 1,017 · see citing works

Initial steps of metastasis: Cell invasion and endothelial transmigration

van Zijl, F., Krupitza, G., & Mikulits, W. (2011) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2011.05.002 · Cited by 884 · see citing works

The therapeutic journey of benzimidazoles: A review

Bansal, Y., & Silakari, O. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.09.013 · Cited by 817 · see citing works

Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy

Edlmann, E., Giorgi-Coll, S., Whitfield, P. C., Carpenter, K. L. H., & Hutchinson, P. J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0881-y · Cited by 740 · see citing works

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 772 · see citing works

Cancer-related inflammation: Common themes and therapeutic opportunities

Balkwill, F. R., & Mantovani, A. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.12.005 · Cited by 685 · see citing works

Infection regulates pro-resolving mediators that lower antibiotic requirements

Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012) · Nature · doi:10.1038/nature11042 · Cited by 664 · see citing works

Anti-inflammatory activity of natural dietary flavonoids

Pan, M., Lai, C., & Ho, C. (2010) · Food & Function · doi:10.1039/c0fo00103a · Cited by 612 · see citing works

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

Serhan, C. N. (2017) · The FASEB Journal · doi:10.1096/fj.201601222r · Cited by 553 · see citing works

Treating inflammation by blocking interleukin-1 in humans

Dinarello, C. A., & van der Meer, J. W. M. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.008 · Cited by 544 · see citing works

Flavones: An important scaffold for medicinal chemistry

Singh, M., Kaur, M., & Silakari, O. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.07.013 · Cited by 542 · see citing works

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

Zhang, P., Cao, L., Zhou, R., Yang, X., & Wu, M. (2019) · Nature Communications · doi:10.1038/s41467-019-09482-6 · Cited by 503 · see citing works

Inflammasomes in liver diseases

Szabó, G., & Csák, T. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.03.035 · Cited by 498 · see citing works

Protectins and maresins: new pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492 · see citing works

Recent Advances and Uses of Grape Flavonoids as Nutraceuticals

Georgiev, V., Ananga, A., & Tsolova, V. M. (2014) · Nutrients · doi:10.3390/nu6010391 · Cited by 493 · see citing works

Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus

Akash, M. S. H., Rehman, K., & Chen, S. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24402 · Cited by 408 · see citing works

Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy

Liu, H., Lu, X., Hu, Y., & Fan, X. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105263 · Cited by 405 · see citing works

Novel Lipid Mediators Promote Resolution of Acute Inflammation

Spite, M. R., & Serhan, C. N. (2010) · Circulation Research · doi:10.1161/circresaha.110.223883 · Cited by 368 · see citing works

Cyclodextrin–Drug Inclusion Complexes: In Vivo and In Vitro Approaches

Carneiro, S. P., Duarte, F., Heimfarth, L., Quintans, J. D. S. S., Quintans‐Júnior, L. J., da Veiga, V. F., & de Lima, Á. A. N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030642 · Cited by 351 · see citing works

Benzimidazole: An emerging scaffold for analgesic and anti-inflammatory agents

Gaba, M., Singh, S., & Mohan, C. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.01.030 · Cited by 344 · see citing works

Cancer drug discovery by repurposing: teaching new tricks to old dogs

Gupta, S. C., Sung, B., Prasad, S., Webb, L. J., & Aggarwal, B. B. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.06.005 · Cited by 340 · see citing works

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

Yin, C., Ackermann, S., Ma, Z., Mohanta, S. K., Zhang, C., Li, Y., Nietzsche, S., Westermann, M., Peng, L., Hu, D., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0336-8 · Cited by 305 · see citing works

Role of IL-1β in type 2 diabetes

Dinarello, C. A., Donath, M. Y., & Mandrup-Poulsen, T. R. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32833bf6dc · Cited by 330 · see citing works

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

Chiang, N., & Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.005 · Cited by 330 · see citing works

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

Menu, P., Mayor, A., Zhou, R., Tardivel, A., Ichijo, H., Mori, K., & Tschopp, J. (2012) · Cell Death and Disease · doi:10.1038/cddis.2011.132 · Cited by 321 · see citing works

Interleukin‐1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Tilg, H., Moschen, A. R., & Szabó, G. (2016) · Hepatology · doi:10.1002/hep.28456 · Cited by 319 · see citing works

Coumarin: a potential nucleus for anti-inflammatory molecules

Bansal, Y., Sethi, P., & Bansal, G. (2012) · Medicinal Chemistry Research · doi:10.1007/s00044-012-0321-6 · Cited by 321 · see citing works

Chronic adipose tissue inflammation: all immune cells on the stage

Cildir, G., Akıncılar, S. C., & Tergaonkar, V. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.05.001 · Cited by 317 · see citing works

HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

Hull, E. E., Montgomery, M. R., & Leyva, K. J. (2016) · BioMed Research International · doi:10.1155/2016/8797206 · Cited by 316 · see citing works

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

Orlowsky, E. W., & Kraus, V. B. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.140382 · Cited by 299 · see citing works

Pathological mechanisms and therapeutic outlooks for arthrofibrosis

Usher, K. M., Zhu, S., Mavropalias, G., Carrino, J. A., Zhao, J., & Xu, J. (2019) · Bone Research · doi:10.1038/s41413-019-0047-x · Cited by 291 · see citing works

Neutrophil-Mediated Delivery of Therapeutic Nanoparticles across Blood Vessel Barrier for Treatment of Inflammation and Infection

Chu, D., Gao, J., & Wang, Z. (2015) · ACS Nano · doi:10.1021/acsnano.5b05583 · Cited by 284 · see citing works

Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis

Ridker, P. M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313129 · Cited by 260 · see citing works

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology

Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.001 · Cited by 266 · see citing works

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Cai, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256 · see citing works

Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Deng, C., Zhang, Q., He, P., Zhou, B., He, K., Sun, X., Lei, G., Gong, T., & Zhang, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-22454-z · Cited by 252 · see citing works

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

Menu, P., Pellegrin, M., Aubert, J.-F., Bouzourène, K., Tardivel, A., Mazzolai, L., & Tschopp, J. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.18 · Cited by 249 · see citing works

Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway

Kolattukudy, P. E., & Niu, J. (2012) · Circulation Research · doi:10.1161/circresaha.111.243212 · Cited by 246 · see citing works

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

Dalli, J., Winkler, J. W., Colas, R. A., Arnardottir, H. H., Cheng, C.-Y. C., Chiang, N., Petasis, N. A., & Serhan, C. N. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.11.010 · Cited by 246 · see citing works

Advanced nanomedicines for the treatment of inflammatory diseases

Brusini, R., Varna, M., & Couvreur, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.010 · Cited by 244 · see citing works

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α

Berda‐Haddad, Y., Robert, S., Salers, P., Zekraoui, L., Farnarier, C., Dinarello, C. A., Dignat‐George, F., & Kaplanski, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116848108 · Cited by 232 · see citing works

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

Brydges, S. D., Broderick, L., McGeough, M. D., Peña, C. A., Mueller, J. L., & Hoffman, H. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71543 · Cited by 228 · see citing works

The role IL-1 in tumor-mediated angiogenesis

Voronov, E., Carmi, Y., & Apte, R. N. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00114 · Cited by 226 · see citing works

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Cai, X., Xu, Y., Cheung, A. K., Tomlinson, R., Alcázar-Román, A. R., Murphy, L. O., Billich, A., Zhang, B., Feng, Y., Klumpp, M., et al. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.05.010 · Cited by 225 · see citing works

Long non‐coding RNA cox‐2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization

Ye, Y., Xu, Y., Lai, Y., He, W., Li, Y., Wang, R., Luo, X., Chen, R., & Chen, T. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26509 · Cited by 225 · see citing works

Gram‐Positive Antimicrobial Activity of Amino Acid‐Based Hydrogels

Irwansyah, I., Li, Y., Shi, W., Qi, D., Leow, W. R., Tang, M. B. Y., Li, S., & Chen, X. (2014) · Advanced Materials · doi:10.1002/adma.201403339 · Cited by 224 · see citing works

Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management

Zhang, C. Y., Gao, J., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201803618 · Cited by 222 · see citing works

The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation

Moudgil, K. D., & Venkatesha, S. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010095 · Cited by 221 · see citing works

Promoter RNA links transcriptional regulation of inflammatory pathway genes

Matsui, M., Chu, Y., Zhang, H., Gagnon, K. T., Shaikh, S., Kuchimanchi, S., Manoharan, M., Corey, D. R., & Janowski, B. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt777 · Cited by 219 · see citing works

High yield, scalable and remotely drug-loaded neutrophil-derived extracellular vesicles (EVs) for anti-inflammation therapy

Gao, J., Wang, S., & Wang, Z. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.003 · Cited by 218 · see citing works

The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

Liu, J., Liu, Z., Pang, Y., & Zhou, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01343-7 · Cited by 219 · see citing works

Anti-inflammatory activity of phytochemicals from medicinal plants and their nanoparticles: A review

Gonfa, Y. H., Tessema, F. B., Bachheti, A., Rai, N., Tadesse, M. G., Singab, A. N. B., Chaubey, K. K., & Bachheti, R. K. (2023) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2023.100152 · Cited by 217 · see citing works

Signaling by IL-31 and functional consequences

Cornelissen, C., Lüscher‐Firzlaff, J., Baron, J. M., & Lüscher, B. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2011.07.006 · Cited by 207 · see citing works

Therapeutic potential of monoacylglycerol lipase inhibitors

Mulvihill, M. M., & Nomura, D. K. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.025 · Cited by 199 · see citing works

Therapeutic potential of pyrrole and pyrrolidine analogs: an update

Basha, N. J., Basavarajaiah, S. M., & Shyamsunder, K. (2022) · Molecular Diversity · doi:10.1007/s11030-022-10387-8 · Cited by 202 · see citing works

Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways

Hou, X., Tong, Q., Wang, W., Shi, C., Xiong, W., Chen, J., Liu, X., & Fang, J. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00275 · Cited by 197 · see citing works

The resolution of inflammation: the devil in the flask and in the details

Serhan, C. N. (2011) · The FASEB Journal · doi:10.1096/fj.11-0502ufm · Cited by 195 · see citing works

Toll-like receptor 3, RIG-I-like receptors and the NLRP3 inflammasome: Key modulators of innate immune responses to double-stranded RNA viruses

Yu, M., & Levine, S. J. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.02.001 · Cited by 191 · see citing works

The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing

Kou, X., Xu, X., Chen, C., Sanmillan, M. L., Cai, T., Zhou, Y., Giraudo, C. G., Le, A. D., & Shi, S. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8524 · Cited by 188 · see citing works

Adipose and Liver Expression of Interleukin (IL)-1 Family Members in Morbid Obesity and Effects of Weight Loss

Moschen, A. R., Molnar, C., Enrich, B., Geiger, S., Ebenbichler, C. F., & Tilg, H. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00108 · Cited by 185 · see citing works

Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes

Dalli, J., Colas, R. A., Quintana, C., Barragan-Bradford, D., Hurwitz, S., Levy, B. D., Choi, A. M. K., Serhan, C. N., & Baron, R. M. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002014 · Cited by 186 · see citing works

Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation

Bai, R., Yao, C., Zhong, Z., Ge, J., Bai, Z., Ye, X., Xie, T., & Xie, Y. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113165 · Cited by 190 · see citing works

Synthesis, bioactive properties, and biomedical applications of intrinsically therapeutic nanoparticles for disease treatment

Nguyen, D. D., & Lai, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.134970 · Cited by 185 · see citing works

Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

Jaismy Jacob, P., Manju, S. L., Radhakrishnan, E. K., & Elias, G. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.06.003 · Cited by 183 · see citing works

Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery

Ge, J., Liu, Z., Zhong, Z., Wang, L., Zhuo, X., Li, J., Jiang, X., Ye, X., Xie, T., & Bai, R. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105817 · Cited by 183 · see citing works

Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke

Zhang, C. Y., Dong, X., Gao, J., Lin, W., Liu, Z., & Wang, Z. (2019) · Science Advances · doi:10.1126/sciadv.aax7964 · Cited by 182 · see citing works

Lactones: Classification, synthesis, biological activities, and industrial applications

Sartori, S. K., Diaz, M. A. N., & Diaz‐Muñoz, G. (2021) · Tetrahedron · doi:10.1016/j.tet.2021.132001 · Cited by 182 · see citing works

Cell membrane-formed nanovesicles for disease-targeted delivery

Gao, J., Chu, D., & Wang, Z. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.024 · Cited by 179 · see citing works

Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

Feng, X., Weng, D., Zhou, F., Owen, Y. D., Qin, H., Zhao, J., Wenyu, Huang, Y., Chen, J., Fu, H., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.06.017 · Cited by 183 · see citing works

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

Li, L., Liu, Y., Chen, H., Li, F.-W., Wu, J., Zhang, H.-K., He, J., Xing, Y.-Z., Chen, Y., Wang, W.-J., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1788 · Cited by 176 · see citing works

Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions

Adiwidjaja, J., McLachlan, A. J., & Boddy, A. V. (2017) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2017.1360279 · Cited by 173 · see citing works

Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk

Goldfine, A. B., & Shoelson, S. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88884 · Cited by 172 · see citing works

Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

Cavalli, G., & Dinarello, C. A. (2015) · Rheumatology · doi:10.1093/rheumatology/kev269 · Cited by 172 · see citing works

Resolvins: Anti-Inflammatory and Proresolving Mediators Derived from Omega-3 Polyunsaturated Fatty Acids

Zhang, M. J., & Spite, M. R. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150726 · Cited by 170 · see citing works

Vascular Macrophages in Atherosclerosis

Xu, H., Jiang, J., Chen, W., Li, W., & Chen, Z. (2019) · Journal of Immunology Research · doi:10.1155/2019/4354786 · Cited by 173 · see citing works

Emerging roles of lactate in acute and chronic inflammation

Fang, Y., Li, Z., Yang, L., Li, W., Wang, Y., Kong, Z., Miao, J., Chen, Y., Bian, Y., & Zeng, L. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01624-8 · Cited by 180 · see citing works

Inflammation as a Therapeutic Target in Atherosclerosis

Nguyen, M. T., Fernando, S., Schwarz, N., Tan, J. T. M., Bursill, C. A., & Psaltis, P. J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081109 · Cited by 171 · see citing works

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis

Negrin, K. A., Flach, R. J. R., DiStefano, M. T., Matevossian, A., Friedline, R. H., Jung, D., Kim, J. K., & Czech, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107265 · Cited by 166 · see citing works

Novel Proresolving Aspirin-Triggered DHA Pathway

Serhan, C. N., Fredman, G., Yang, R., Karamnov, S., Belayev, L., Bazan, N. G., Zhu, M., Winkler, J. W., & Petasis, N. A. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.06.008 · Cited by 164 · see citing works

Thiazolidine-2,4-diones: Progress towards multifarious applications

Jain, V. S., Vora, D. K., & Ramaa, C. S. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.01.029 · Cited by 165 · see citing works

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

Jiang, Y., Wang, M., Huang, K., Zhang, Z., Shao, N., Zhang, Y., Wang, W., & Wang, S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.011 · Cited by 160 · see citing works

Histone Deacetylase Inhibitors for Treating a Spectrum of Diseases Not Related to Cancer

Dinarello, C. A., Fossati, G., & Mascagni, P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00116 · Cited by 160 · see citing works

The Versatility in the Applications of Dithiocarbamates

Ajiboye, T. O., Ajiboye, T. T., Marzouki, R., & Onwudiwe, D. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031317 · Cited by 159 · see citing works

The sterile immune response during hepatic ischemia/reperfusion

van Golen, R. F., van Gulik, T. M., & Heger, M. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.04.006 · Cited by 158 · see citing works

Expanding the Clinical Indications for α1-Antitrypsin Therapy

Lewis, E. C. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00196 · Cited by 157 · see citing works

Host Responses to Biomaterials and Anti‐Inflammatory Design—a Brief Review

Zhou, G., & Groth, T. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201800112 · Cited by 156 · see citing works

Innate Immune Response of Human Alveolar Macrophages during Influenza A Infection

Wang, J., Nikrad, M. P., Travanty, E. A., Zhou, B., Phang, T., Gao, B., Alford, T., Ito, Y., Nahreini, P., Hartshorn, K. L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029879 · Cited by 153 · see citing works

Aggregatibacter actinomycetemcomitans Leukotoxin: A Powerful Tool with Capacity to Cause Imbalance in the Host Inflammatory Response

Johansson, A. (2011) · Toxins · doi:10.3390/toxins3030242 · Cited by 154 · see citing works

HER2 Interacts With CD44 to Up-regulate CXCR4 via Epigenetic Silencing of microRNA-139 in Gastric Cancer Cells

Bao, W., Fu, H., Xie, Q., Wang, L., Zhang, R., Guo, Z., Zhao, J., Meng, Y., Ren, X., Wang, T., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.08.050 · Cited by 152 · see citing works

Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis

Rahimi, M., Charmi, G., Matyjaszewski, K. A., Banquy, X., & Pietrasik, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.01.003 · Cited by 152 · see citing works

Modulating the immune system through nanotechnology

Dacoba, T. G., Ana, O., Torres, D., Crecente‐Campo, J., & Alonso, M. J. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.09.007 · Cited by 146 · see citing works

pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury

Zhang, C. Y., Lin, W., Gao, J., Shi, X., Davaritouchaee, M., Nielsen, A. E., Mancini, R. J., & Wang, Z. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b04051 · Cited by 142 · see citing works

Targeting inflammatory pathways for tumor radiosensitization

Deorukhkar, A., & Krishnan, S. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.039 · Cited by 141 · see citing works

The Search for Potent, Small‐Molecule HDACIs in Cancer Treatment: A Decade After Vorinostat

Zagni, C., Floresta, G., Monciino, G., & Rescifina, A. (2017) · Medicinal Research Reviews · doi:10.1002/med.21437 · Cited by 138 · see citing works

A Comprehensive Review of Anti-Inflammatory Activity: Phytomedicines, In Vitro and In Vivo Models

Vasantha, G., Joel, K. J., & Madhuri, G. (2026) · International Journal of Zoological Investigations · doi:10.33745/ijzi.2026.v12i01.045

Novel Targets for Antiinflammatory and Antiarthritic Agents

Kulkarni, R., Achaiah, G., & Sastry, G. N. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777698945 · Cited by 52 · see citing works

[Anti-inflammatory drugs : from old classical ones to biotherapies and JAK inhibitors].

Scheen, A. J. (2022) · PubMed · Cited by 1 · see citing works

A Systemic Review on Plant Based Anti-Inflammatory Agents

Prajapati Rahul1*, G. M. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.14993025

Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics

Li, P., Zheng, Y., & Chen, X. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00460 · Cited by 349 · see citing works