Identification of a Novel Astrovirus (Astrovirus VA1) Associated with an Outbreak of Acute Gastroenteritis
Open accessAbstract
The etiology of a large proportion of gastrointestinal illness is unknown. In this study, random Sanger sequencing and pyrosequencing approaches were used to analyze fecal specimens from a gastroenteritis outbreak of unknown etiology in a child care center. Multiple sequences with limited identity to known astroviruses were identified. Assembly of the sequences and subsequent reverse transcription-PCR (RT-PCR) and rapid amplification of cDNA ends generated a complete genome of 6,586 nucleotides. Phylogenetic analysis demonstrated that this virus, named astrovirus VA1 (AstV-VA1), is highly divergent from all previously described astroviruses. Based on RT-PCR, specimens from multiple patients in this outbreak were unequivocally positive for Ast-VA1.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Astroviruses have a broad host range and are frequently detected in the faeces of mammals, birds, and humans with gastroenteritis.
“Astroviruses have a broad host range (Donato and Vijaykrishna 2017) and are frequently detected in the faeces of mammals, birds, and humans with gastroenteritis (Finkbeiner et al. 2009; De Benedictis et al. 2011).”
From Red fox viromes in urban and rural landscapes (2020) · cites this paper as Finkbeiner et al. 2009
The cited paper supports detection in humans: its Abstract reports astrovirus VA1 in fecal samples from a gastroenteritis outbreak and describes human astroviruses associated with diarrhea. It also notes that astroviruses infect a variety of species, but does not establish that they are frequently detected in the feces of mammals and birds with gastroenteritis. The sentence attributes the separate broad-host-range clause to Donato and Vijaykrishna, not to this paper. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
No references could be resolved yet.
Research works printed but not linked: 21
- [1]Akihara, S., T. G. Phan, T. A. Nguyen, G. Hansman, S. Okitsu, and H. Ushijima. 2005. Existence of multiple outbreaks of viral gastroenteritis among infants in a day care center in Japan. Arch. Virol. 150:2061-2075. [DOI] [PubMed] [Google Scholar]
- [2]Caracciolo, S., C. Minini, D. Colombrita, I. Foresti, M. Avolio, G. Tosti, S. Fiorentini, and A. Caruso. 2007. Detection of sporadic cases of norovirus infection in hospitalized children in Italy. New Microbiol. 30:49-52. [PubMed] [Google Scholar]
- [3]Chu, D. K., L. L. Poon, Y. Guan, and J. S. Peiris. 2008. Novel astroviruses in insectivorous bats. J. Virol. 82:9107-9114. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [4]Davidson, G., R. Townley, R. F. Bishop, I. Holmes, and B. Ruck. 1975. Importance of a new virus in acute sporadic enteritis in children. Lancet i:242-246. [DOI] [PubMed] [Google Scholar]
- [5]Finkbeiner, S. R., A. F. Allred, P. I. Tarr, E. J. Klein, C. D. Kirkwood, and D. Wang. 2008. Metagenomic analysis of human diarrhea: viral detection and discovery. PLoS Pathog. 4:e1000011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [6]Finkbeiner, S. R., C. D. Kirkwood, and D. Wang. 2008. Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea. Virol. J. 5:117. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [7]Glass, R. I., J. Noel, D. Mitchell, J. E. Herrmann, N. R. Blacklow, L. K. Pickering, P. Dennehy, G. Ruiz-Palacios, M. L. de Guerrero, and S. S. Monroe. 1996. The changing epidemiology of astrovirus-associated gastroenteritis: a review. Arch. Virol. Suppl. 12:287-300. [DOI] [PubMed] [Google Scholar]
- [8]Jiang, B., S. S. Monroe, E. V. Koonin, S. E. Stine, and R. I. Glass. 1993. RNA sequence of astrovirus: distinctive genomic organization and a putative retrovirus-like ribosomal frameshifting signal that directs the viral replicase synthesis. Proc. Natl. Acad. Sci. USA 90:10539-10543. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [9]Jonassen, C. M., T. O. Jonassen, and B. Grinde. 1998. A common RNA motif in the 3′ end of the genomes of astroviruses, avian infectious bronchitis virus and an equine rhinovirus. J. Gen. Virol. 79(Pt 4):715-718. [DOI] [PubMed] [Google Scholar]
- [10]Kirkwood, C. D., R. Clark, N. Bogdanovic-Sakran, and R. F. Bishop. 2005. A 5-year study of the prevalence and genetic diversity of human caliciviruses associated with sporadic cases of acute gastroenteritis in young children admitted to hospital in Melbourne, Australia (1998-2002). J. Med. Virol. 77:96-101. [DOI] [PubMed] [Google Scholar]
- [11]Klein, E. J., D. R. Boster, J. R. Stapp, J. G. Wells, X. Qin, C. R. Clausen, D. L. Swerdlow, C. R. Braden, and P. I. Tarr. 2006. Diarrhea etiology in a children's hospital emergency department: a prospective cohort study. Clin. Infect. Dis. 43:807-813. [DOI] [PubMed] [Google Scholar]
- [12]Koci, M. D., and S. Schultz-Cherry. 2002. Avian astroviruses. Avian Pathol. 31:213-227. [DOI] [PubMed] [Google Scholar]
- [13]Lyman, W. H., J. F. Walsh, J. B. Kotch, D. J. Weber, E. Gunn, and J. Vinje. 2009. Prospective study of etiologic agents of acute gastroenteritis outbreaks in child care centers. J. Pediatr. 154:253-257. [DOI] [PubMed] [Google Scholar]
- [14]Mendez, E., and C. F. Arias. 2007. Astroviruses, p. 981-1000. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 5th ed., vol. 1. Lippincott Willliams & Wilkins, Philadelphia, PA. [Google Scholar]
- [15]Monceyron, C., B. Grinde, and T. O. Jonassen. 1997. Molecular characterisation of the 3′-end of the astrovirus genome. Arch. Virol. 142:699-706. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [16]Oka, T., K. Katayama, G. S. Hansman, T. Kageyama, S. Ogawa, F. T. Wu, P. A. White, and N. Takeda. 2006. Detection of human sapovirus by real-time reverse transcription-polymerase chain reaction. J. Med. Virol. 78:1347-1353. [DOI] [PubMed] [Google Scholar]
- [17]Soares, C. C., M. C. Maciel de Albuquerque, A. G. Maranhao, L. N. Rocha, M. L. Ramirez, F. J. Benati, C. Timenetsky Mdo, and N. Santos. 2008. Astrovirus detection in sporadic cases of diarrhea among hospitalized and non-hospitalized children in Rio De Janeiro, Brazil, from 1998 to 2004. J. Med. Virol. 80:113-117. [DOI] [PubMed] [Google Scholar]
- [18]Svraka, S., E. Duizer, H. Vennema, E. de Bruin, B. van der Veer, B. Dorresteijn, and M. Koopmans. 2007. Etiological role of viruses in outbreaks of acute gastroenteritis in The Netherlands from 1994 through 2005. J. Clin. Microbiol. 45:1389-1394. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [20]Toffan, A., C. M. Jonassen, C. De Battisti, E. Schiavon, T. Kofstad, I. Capua, and G. Cattoli. 4 May 2009, posting date. Genetic characterization of a new astrovirus detected in dogs suffering from diarrhea. Vet. Microbiol., doi: 10.1016/j.vetmic.2009.04.031. [DOI] [PMC free article] [PubMed] · DOI
- [21]Trujillo, A. A., K. A. McCaustland, D. P. Zheng, L. A. Hadley, G. Vaughn, S. M. Adams, T. Ando, R. I. Glass, and S. S. Monroe. 2006. Use of TaqMan real-time reverse transcription-PCR for rapid detection, quantification, and typing of norovirus. J. Clin. Microbiol. 44:1405-1412. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [22]Wang, D., A. Urisman, Y. T. Liu, M. Springer, T. G. Ksiazek, D. D. Erdman, E. R. Mardis, M. Hickenbotham, V. Magrini, J. Eldred, J. P. Latreille, R. K. Wilson, D. Ganem, and J. L. DeRisi. 2003. Viral discovery and sequence recovery using DNA microarrays. PLoS Biol. 1:E2. [DOI] [PMC free article] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285 · see citing works
Self-citationA decade’s perspective on DNA sequencing technology
Mardis, E. R. (2011) · Nature · doi:10.1038/nature09796 · Cited by 913 · see citing works
Metagenomics and future perspectives in virus discovery
Mokili, J., Rohwer, F., & Dutilh, B. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.12.004 · Cited by 606 · see citing works
“The SISPA method was used successfully for the discovery of Hepatitis E virus [58, 59] , Norwalk virus [60] , Human astrovirus [61, 62] , and Parvoviruses 2 and 3 [63] .”
De Benedictis, P., Schultz-Cherry, S., Burnham, A., & Cattoli, G. (2011) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2011.07.024 · Cited by 479 · see citing works
“…geneti- cally close to rat astroviruses discovered in Hong Kong (Chu et al., 2010; Finkbeiner et al., 2008b, 2009a, c), and HAstVs genetically related to MiAstVs and OAstVs, thus called human, mink-, and ovinelike, HMOAstVs A, B, and C and AstV-VA1 (Finkbeiner et al., 2009b; Kapoor et al., 2009).”
BackgroundMethodInfluentialHuman viruses: discovery and emergence
Woolhouse, M., Scott, F., Hudson, Z., Howey, R., & Chase-Topping, M. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0354 · Cited by 399 · see citing works
The Fecal Viral Flora of Wild Rodents
Phan, T., Kapusinszky, B., Wang, C., Rose, R. K., Lipton, H., & Delwart, E. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002218 · Cited by 363 · see citing works
“The first astrovirus genome from a mouse clustered with a clade containing mink, sheep, and recently identified human astroviruses [89,91].”
BackgroundNext-generation sequencing and metagenomic analysis: a universal diagnostic tool in plant virology.
Adams, I., Glover, R., Monger, W., Mumford, R., Jackeviciene, E., Navalinskienė, M., Samuitienė, M., & Boonham, N. (2009) · Molecular plant pathology · doi:10.1111/j.1364-3703.2009.00545.x · Cited by 351 · see citing works
The Fecal Virome of Pigs on a High-Density Farm
Shan, T., Li, L., Peter Simmonds, K., Wang, C., Moeser, A. J., & Delwart, E. (2011) · Journal of Virology · doi:10.1128/jvi.05217-11 · Cited by 340 · see citing works
“Humans are also infected with several distinct astroviruses (40, 41, 57).”
BackgroundInfluentialAstrovirus Encephalitis in Boy with X-linked Agammaglobulinemia
Quan, P.-L., Wagner, T. A., Briese, T., Torgerson, T., Hornig, M., Tashmukhamedova, A., Firth, C., Palacios, G., Baisre-De-Leon, A., Paddock, C., et al. (2010) · Emerging Infectious Diseases · doi:10.3201/eid1606.091536 · Cited by 332 · see citing works
“The recent fi nding of an astrovirus closely related to HAstV-PS in fecal samples from children from Virginia with acute gastroenteritis (28) suggests that these novel viruses are circulating widely in humans across the United States.”
BackgroundBosch, A., Pintó, R., & Guix, S. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-14 · Cited by 311 · see citing works
“with diarrhea in Virginia (VA) (28) and in Nigeria, Pakistan, and”
BackgroundMetagenomics: The Next Culture-Independent Game Changer
Forbes, J., Knox, N., Ronholm, J., Pagotto, F., & Reimer, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01069 · Cited by 300 · see citing works
“Throughout the last decade, viral metagenomics (viromics) has been used as a tool to diagnose cases of acute gastroenteritis and further, to determine etiological causation retrospectively in gastroenteritis outbreaks (Finkbeiner et al., 2009; Smits et al., 2014).”
MethodNaccache, S. N., Peggs, K. S., Mattes, F. M., Phadke, R., Garson, J. A., Grant, P., Samayoa, E., Federman, S., Miller, S., Lunn, M. P., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu912 · Cited by 294 · see citing works
“rhea in children [4, 5]; 95% identity to HAstV-SG, detected in brain tissue from a boy with X-linked agammaglobulinemia and fatal encephalitis [6]; and 52%–54% identity to AstVs linked to”
BackgroundHandley, S., Thackray, L. B., Zhao, G.-Y., Presti, R., Miller, A. D., Droit, L., Abbink, P., Maxfield, L. F., Kambal, A., Duan, E.-N., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.024 · Cited by 287 · see citing works
Self-citationHigh Variety of Known and New RNA and DNA Viruses of Diverse Origins in Untreated Sewage
Ng, T. F. F., Marine, R. L., Wang, C., Peter Simmonds, K., Kapusinszky, B., Bodhidatta, L., Oderinde, B. S., Wommack, K. E., & Delwart, E. (2012) · Journal of Virology · doi:10.1128/jvi.00869-12 · Cited by 270 · see citing works
Novel Surveillance Network for Norovirus Gastroenteritis Outbreaks, United States
Vega, E., Barclay, L., Gregoricus, N., Williams, K., Lee, D., & Vinjé, J. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1708.101837 · Cited by 248 · see citing works
“Future CaliciNet expansion will include other gastroenteritis viruses, such as sapovirus and astrovirus, as well as add capability for CaliciNet members to submit fecal samples from patients involved in norovirus-negative outbreaks to CDC for further testing, including novel pathogen discovery sequencing technologies…”
BackgroundSelf-citationBlomström, A., Widén, F., Hammer, A., Belák, S., & Berg, M. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01040-10 · Cited by 238 · see citing works
Astrovirus VA1/HMO-C: An Increasingly Recognized Neurotropic Pathogen in Immunocompromised Patients
Brown, J. R., Morfopoulou, S., Hubb, J., Emmett, W., Ip, W., Shah, D., Brooks, T., Paine, S., Anderson, G., Virasami, A., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu940 · Cited by 207 · see citing works
“Similar to HAstV 1–8, antibodies against HMO-C viruses have been shown to increase with age, reaching a prevalence of 65% in adults in the United States [21].”
BackgroundHuman stool contains a previously unrecognized diversity of novel astroviruses
Finkbeiner, S. R., Holtz, L. R., Jiang, Y., Rajendran, P., Franz, C., Zhao, G., Kang, G., & Wang, D. (2009) · Virology Journal · doi:10.1186/1743-422x-6-161 · Cited by 195 · see citing works
“We recently identified two highly divergent members of the astrovirus family, astrovirus MLB1 (AstV-MLB1) [12-14] and astrovirus VA1 (AstV-VA1) [15], in patients with sporadic diarrhea and patients from a gastroenteritis outbreak, respectively.”
Self-citationThe Broad Host Range and Genetic Diversity of Mammalian and Avian Astroviruses
Donato, C., & Vijaykrishna, D. (2017) · Viruses · doi:10.3390/v9050102 · Cited by 196 · see citing works
“A study in the USA revealed the high level of co-infections in pigs (13.9%), revealing the frequent opportunity for recombination, especially between viruses of different lineages [61].”
BackgroundInfluentialAstrovirus Biology and Pathogenesis.
Cortez, V., Meliopoulos, V. A., Karlsson, E., Hargest, V., Johnson, C. N., & Schultz-Cherry, S. (2017) · Annual Review of Virology · doi:10.1146/annurev-virology-101416-041742 · Cited by 194 · see citing works
A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America
Greninger, A. L., Chen, E. C., Sittler, T., Scheinerman, A., Roubinian, N., Yu, G., Kim, E., Pillai, D. R., Guyard, C., Mazzulli, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013381 · Cited by 193 · see citing works
“Nearly all previous studies of metagenomic sequencing of viruses from human clinical material for detection and discovery have employed pyrosequencing [6,16,17,18,19,20,21,22,32,42,43].”
BackgroundMethodEpidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond
Vu, D., Bosch, A., Pintó, R., & Guix, S. (2017) · Viruses · doi:10.3390/v9020033 · Cited by 184 · see citing works
Metagenomics for the study of viruses in urban sewage as a tool for public health surveillance
Fernández-Cassi, X., Timoneda, N., Martínez‐Puchol, S., Rusiñol, M., Rodríguez-Manzano, J., Figuerola, N., Bofill-Mas, S., Abril, J. F., & Gironés, R. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.08.249 · Cited by 187 · see citing works
“More precisely, the application of NGS techniques has facilitated the detection of these later mentioned animal recombinant astroviruses (Finkbeiner et al., 2009; Kapoor et al., 2009), which are related to neurological disorders in immunocompromised patients (Brown et al., 2015).”
BackgroundEmerging View of the Human Virome
Wylie, K., Weinstock, G., & Storch, G. (2012) · Translational Research: The Journal of Laboratory and Clinical Medicine · doi:10.1016/j.trsl.2012.03.006 · Cited by 145 · see citing works
“In recent years, many novel eukaryotic viruses have been discovered or characterized using sequencing, including viruses in the following groups: arenaviruses, 48 astroviruses, 46, 49, 50 rhinoviruses, 51 nodoviruses, 25 coronaviruses, 20 polyomaviruses, 52,53 bocaviruses, 54 enteroviruses, 55 and klasseviruses, 56 am…”
BackgroundAcute Diarrhea in West African Children: Diverse Enteric Viruses and a Novel Parvovirus Genus
Phan, T., Vo, N., Bonkoungou, I., Kapoor, A., Barro, N., O'Ryan, M., Kapusinszky, B., Wang, C.-L., & Delwart, E. (2012) · Journal of Virology · doi:10.1128/jvi.01427-12 · Cited by 137 · see citing works
“Metagenomic analyses of human fecal samples have shownfrequent coinfections with known enteric pathogens (26, 70) and the presence of numerous novel viral species, particularly members of the Picornaviridae (20, 31, 33, 37, 40, 51), Astroviridae (26, 27, 41) Parvoviridae (39, 45), and Circoviridae (49, 58) families of…”
BackgroundAstrovirus MLB2, a New Gastroenteric Virus Associated with Meningitis and Disseminated Infection
Cordey, S., Vu, D., Schibler, M., L'Huillier, A., Brito, F., Docquier, M., Posfay-Barbe, K., Petty, T., Turin, L., Zdobnov, E., et al. (2016) · Emerging Infectious Diseases · doi:10.3201/eid2205.151807 · Cited by 133
Frémond, M., Pérot, P., Muth, E., Cros, G., Dumarest, M., Mahlaoui, N., Seilhean, D., Desguerre, I., Hébert, C., Corre-Catelin, N., et al. (2015) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piv040 · Cited by 127 · see citing works
“Another clade, closer to porcine, mink, and ovine astroviruses, has been identified in a case of human gastroenteritis [9] and is referred to as the VA1/ HMO-C clade.”
BackgroundAstrovirus evolution and emergence
Wohlgemuth, N., Honce, R., & Schultz-Cherry, S. (2019) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2019.01.009 · Cited by 119 · see citing works
“Using genomic tools, including phylogenetic reconstructions, researchers discovered that the novel human astroviruses phylogenetically clustered more closely with animal astroviruses strains than the classic HAstV-1 strains (Finkbeiner et al., 2008a , 2009a , 2008b , 2009b , Kapoor et al., 2009 ).”
BackgroundMethodXiao, C.-T., Gimenez-Lirola, L., Gerber, P., Jiang, Y.-H., Halbur, P., & Opriessnig, T. (2013) · Journal of General Virology · doi:10.1099/vir.0.048744-0 · Cited by 119 · see citing works
“, 2010) or acute gastroenteritis (Finkbeiner et al., 2009) have been reported previously.”
BackgroundInfluentialIdentification and Nearly Full-Length Genome Characterization of Novel Porcine Bocaviruses
Cheng, W.-X., Li, J.-S., Huang, C.-P., Yao, D.-P., Liu, N., Cui, S.-X., Jin, Y., & Duan, Z. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013583 · Cited by 114
Neurotropic Astrovirus in Cattle with Nonsuppurative Encephalitis in Europe
Bouzalas, I., Wüthrich, D., Walland, J., Drögemüller, C., Zurbriggen, A., Vandevelde, M., Oevermann, A., Bruggmann, R., & Seuberlich, T. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01195-14 · Cited by 110 · see citing works
“With the development of tools for pathogen discovery, previously unknown astroviruses such as HuAstV-MLB (28), HuAstV-VA1 (29), and human-mink-ovine-like astrovirus (HMO-AstV) (30) have been identified.”
MethodDetection of novel astroviruses in urban brown rats and previously known astroviruses in humans
Chu, D., Chin, A. W. H., Smith, G. J. D., Chan, K., Guan, Y., Peiris, J. M. M., & Poon, L. (2010) · Journal of General Virology · doi:10.1099/vir.0.022764-0 · Cited by 102 · see citing works
Adiliaghdam, F., Amatullah, H., Digumarthi, S., Saunders, T. L., Rahman, R., Wong, L., Sadreyev, R. I., Droit, L., Paquette, J., Goyette, P., et al. (2022) · Science immunology · doi:10.1126/sciimmunol.abn6660 · Cited by 99 · see citing works
“To evaluate samples for both RNA and DNA viruses, the total nucleic acids were randomly amplified as described previously (65, 66) using barcoded primers consisting of a base-balanced 16-nucleotide– specific sequence upstream of a random 15-mer and used for NEBNext library construction (New England Biolabs).”
MethodSchlaberg, R., Queen, K., Simmon, K. E., Tardif, K. D., Stockmann, C., Flygare, S., Kennedy, B. J., Voelkerding, K., Bramley, A., Zhang, J., et al. (2017) · Journal of Infectious Diseases · doi:10.1093/infdis/jix148 · Cited by 99 · see citing works
“Samples (5 μl of total nucleic acid) were tested with broadly reactive PVG PCR for the following viral families/genera: Adenoviridae [21] [22] [23] [24] [25] [26] [27] [28] .”
Self-citationHigh Throughput Sequencing for Detection of Foodborne Pathogens
Sekse, C., Holst-Jensen, A., Dobrindt, U., Johannessen, G. S., Li, W., Spilsberg, B., & Shi, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02029 · Cited by 98 · see citing works
“HTS has accelerated the study of viral genetics, the assembly of novel viral genomes, and molecular epidemiology of viral outbreaks (Finkbeiner et al., 2009; Kundu et al., 2013; Wong et al., 2013; Smits et al., 2014; Ganova-Raeva et al., 2015) .”
BackgroundKolawole, A. O., Mirabelli, C., Hill, D. R., Svoboda, S. A., Janowski, A. B., Passalacqua, K. D., Rodriguez, B. N., Dame, M., Freiden, P., Berger, R. P., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008057 · Cited by 97 · see citing works
“VA1 is a non-canonical HAstV that can cause encephalitis in immunocompromised patients [16, 17], and it was the first non-canonical HAstV to be cultured [3].”
BackgroundSelf-citationJohnson, C. N., Hargest, V., Cortez, V., Meliopoulos, V. A., & Schultz-Cherry, S. (2017) · Viruses · doi:10.3390/v9010022 · Cited by 96
“The HAstV‐VA1–VA3 viruses were first discovered in an outbreak of gastroenteritis in Virginia, USA [44,45]; HAstV‐VA4 in a cohort of Indian children with diarrhea [43]; and HAstV‐VA5 in a cohort in Gambia [46].”
BackgroundInfluentialNovel human astroviruses: Novel human diseases?
Vu, D., Cordey, S., Brito, F., & Kaiser, L. (2016) · Journal of Clinical Virology · doi:10.1016/j.jcv.2016.07.004 · Cited by 95 · see citing works
Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia
Meyer, C. T., Bauer, I. K., Antonio, M., Adeyemi, M., Saha, D., Oundo, J., Ochieng, J. B., Omore, R., Stine, O., Wang, D., et al. (2015) · Virology Journal · doi:10.1186/s12985-015-0299-z · Cited by 93 · see citing works
“VA1/HMO-C was first identified in an unexplained outbreak of gastroenteritis [14] and has since been detected in the brain of multiple immunocompromised patients with encephalitis [26–28].”
Self-citationSato, M., Kuroda, M., Kasai, M., Matsui, H., Fukuyama, T., Katano, H., & Tanaka-Taya, K. (2016) · Journal of Clinical Virology · doi:10.1016/j.jcv.2016.03.010 · Cited by 90
Viruses Causing Gastroenteritis: The Known, The New and Those Beyond
Munnink, B. O., & van der Hoek, L. (2016) · Viruses · doi:10.3390/v8020042 · Cited by 87 · see citing works
“The first clade consists of the VA-1, VA-2, VA-3, VA-4, and VA-5 astroviruses, which are genetically related to feline and porcine astroviruses, while the second clade consists of the MLB1, MLB2 and MLB3 astroviruses and form a separate cluster [55, 57, [74] [75] [76] [77] [78] .”
BackgroundCharacterization of a novel gyrovirus in human stool and chicken meat
Chu, D., Poon, L., Chiu, S., Chan, K., Ng, E. M., Bauer, I. K., Cheung, T. K. W., Ng, I., Guan, Y., Wang, D., et al. (2012) · Journal of Clinical Virology · doi:10.1016/j.jcv.2012.07.001 · Cited by 87
Self-citationHigh throughput sequencing reveals diversity of Human Papillomaviruses in cutaneous lesions
Ekström, J., Bzhalava, D., Svenback, D., Forslund, O., & Dillner, J. (2011) · International Journal of Cancer · doi:10.1002/ijc.26204 · Cited by 87
Identification of Novel Viruses Using VirusHunter -- an Automated Data Analysis Pipeline
Zhao, G.-Y., Krishnamurthy, S. R., Cai, Z., Popov, V., da Rosa, A. P. A. T., Guzmán, H., Cao, S., Virgin, H. W., Tesh, R., & Wang, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078470 · Cited by 83 · see citing works
“Many novel viruses have been detected in human specimens, such as Merkel polyomavirus [4], astrovirus VA1 [5] and Lujo virus [6].”
BackgroundSelf-citationJiang, H.-B., Holtz, L. R., Bauer, I. K., Franz, C. J., Zhao, G.-Y., Bodhidatta, L., Shrestha, S., Kang, G., & Wang, D. (2012) · Virology · doi:10.1016/j.virol.2012.09.040 · Cited by 83 · see citing works
“The second clade contains VA1, VA2 and VA3 (also known as HMO-A, HMO-B and HMO-C).”
BackgroundInfluentialSelf-citationKarlsson, E., Small, C. T., Freiden, P., Feeroz, M., Matsen, F., San, S., Hasan, M., Wang, D., Jones-Engel, L., & Schultz-Cherry, S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005225 · Cited by 80 · see citing works
“In contrast to bat AstVs, NHP AstVs are distributed throughout the Astroviridae family Based on the high prevalence rate and genetic diversity of AstV detected in bats compared to other species, bats have been proposed as a pimary natural reservoir for AstVs and possibly as host of the most recent conmon ancestor of t…”
BackgroundInfluentialSelf-citationAdaptive Immunity Restricts Replication of Novel Murine Astroviruses
Yokoyama, C. C., Loh, J., Zhao, G.-Y., Stappenbeck, T., Wang, D., Huang, H. V., Virgin, H., & Thackray, L. B. (2012) · Journal of Virology · doi:10.1128/jvi.02018-12 · Cited by 80 · see citing works
“Human astrovirus 1 (HAstV1) to HAstV8 are an important cause of gastroenteritis in pediatric inpatients and outpatients, HIV-infected and immunocompromised populations, and the elderly (9, 10, 12, 16, 21, 22, 24, 28, 39, 44, 48, 53, 63).”
BackgroundSelf-citationBurbelo, P., Ching, K. H., Esper, F. L., Iadarola, M., Delwart, E., Lipkin, W., & Kapoor, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022576 · Cited by 79 · see citing works
Human Parvovirus 4 as Potential Cause of Encephalitis in Children, India
Benjamin, L., Lewthwaite, P., Vasanthapuram, R., Zhao, G.-Y., Sharp, C. P., Simmonds, P., Wang, D., & Solomon, T. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1708.110165 · Cited by 79
“The raw sequence reads were deconvoluted on the basis of the barcode and then processed through a standardized bioinformatic pipeline (2).”
Self-citationObservational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
Lambert, S., Ware, R., Cook, A., Maguire, F. A., Whiley, D., Bialasiewicz, S., Mackay, I., Wang, D., Sloots, T., Nissen, M., et al. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-002134 · Cited by 69
Self-citationApplication of high-throughput DNA sequencing in phytopathology.
Studholme, D., Glover, R., & Boonham, N. (2011) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-072910-095408 · Cited by 68 · see citing works
Delwart, E. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.02.012 · Cited by 63 · see citing works
Astrovirus MLB1 Is Not Associated with Diarrhea in a Cohort of Indian Children
Holtz, L. R., Bauer, I. K., Rajendran, P., Kang, G., & Wang, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028647 · Cited by 63
“Since 2008, five highly divergent astroviruses have been discovered in human diarrhea specimens: MLB1 [8], astrovirus MLB2 (MLB2) [9], astrovirus VA1 (VA1) [10], astrovirus VA2 (VA2) [9], and astrovirus VA3 (VA3) [9].”
BackgroundSelf-citationEvidence of a Recombinant Wild-Type Human Astrovirus Strain from a Kenyan Child with Gastroenteritis
Wolfaardt, M., Kiulia, N., Mwenda, J., & Taylor, M. B. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01093-10 · Cited by 63 · see citing works
Metagenomic Analysis of Viruses in Feces from Unsolved Outbreaks of Gastroenteritis in Humans
Moore, N., Wang, J., Hewitt, J., Croucher, D., Williamson, D., Paine, S., Yen, S., Greening, G., & Hall, R. J. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.02029-14 · Cited by 60 · see citing works
“A more tenable explanation could be a “diagnostic gap,” a theory also suggested by others (5, 13, 30).”
BackgroundDetection and genetic characterization of a novel pig astrovirus: relationship to other astroviruses
Laurin, M., Dastor, M., & L'Homme, Y. (2011) · Archives of Virology · doi:10.1007/s00705-011-1088-7 · Cited by 57
Molecular characterization of a porcine astrovirus strain in China
Lan, D.-L., Ji, W., Shan, T., Cui, L., Yang, Z.-B., Yuan, C.-L., & Hua, X.-G. (2011) · Archives of Virology · doi:10.1007/s00705-011-1050-8 · Cited by 57
“In humans, eight classical human astroviruses (HAstV) are known [6, 25], and novel genotypes have continuously emerged in recent years [7, 8, 12].”
BackgroundUse of Illumina Deep Sequencing Technology To Differentiate Hepatitis C Virus Variants
Ninomiya, M., Ueno, Y., Funayama, R., Nagashima, T., Nishida, Y., Kondo, Y., Inoue, J., Kakazu, E., Kimura, O., Nakayama, K., et al. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.05715-11 · Cited by 50
“NS3 Patient 1 3426 7 S gCC A 3447 14 L (C/t/g)TT L/F/V (67 [89]/6 [8]/2 [3]) 3495 30 D GAg E 3513 36 L gTt V 3588 61 S (T/g)CG S/A (48 [71]/20 [29]) 3591 62 K AgG R 3618 71 I gTC V 3645 80 Q CtG L 3663 86 P CaG Q 3747 114 V aTc I 3801 132 I gTC V 3855 150 V GcT A 3915 170 I gT(A/g) V 4149 248 I gTC V 4152 249 E GAc D…”
Reuter, G., Pankovics, P., & Boros, Á. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00040-18 · Cited by 49 · see citing works
“Finally, the MAstV9 species includes astrovirus clades VA1 (or HMO-C) (23) and VA3 (or HMO-B) (19, 21, 24).”
InfluentialIdentification and characterization of deer astroviruses.
Smits, S., van Leeuwen, M., Kuiken, T., Hammer, A., Simon, J., & Osterhaus, A. (2010) · Journal of General Virology · doi:10.1099/vir.0.024067-0 · Cited by 49 · see citing works
“The phylogenetic topology determined in this study is largely in agreement with previous analyses of astrovirus phylogeny (Finkbeiner et al., 2008, 2009a, b, c; Kapoor et al., 2009; Rivera et al., 2010).”
ResultRed fox viromes in urban and rural landscapes
Campbell, S. J., Ashley, W., Gil-Fernandez, M., Newsome, T. M., Di Giallonardo, F., Ortiz-Baez, A. S., Mahar, J. E., Towerton, A. L., Gillings, M., Holmes, E. C., et al. (2020) · Virus Evolution · doi:10.1093/ve/veaa065 · Cited by 47 · see citing works
Viral gastroenteritis in children in Colorado 2006–2009
Osborne, C. M., Montano, A., Robinson, C., Schultz-Cherry, S., & Dominguez, S. (2015) · Journal of Medical Virology · doi:10.1002/jmv.24022 · Cited by 47 · see citing works
“…and the four known endemic humans coronavirus (order: Nidovirales, family: Coronaviridae, genus: Alphacoronavirus species: human coronavirus 229E and NL63; genus: Betacoronavirus, species: human coronavirus HKU1 and OC43) [Kuypers et al., 2007; Dominguez et al., 2009; Finkbeiner et al., 2009a,b].”
BackgroundPropagation of Astrovirus VA1, a Neurotropic Human Astrovirus, in Cell Culture
Janowski, A. B., Bauer, I. K., Holtz, L. R., & Wang, D. (2017) · Journal of Virology · doi:10.1128/jvi.00740-17 · Cited by 45
“Stool samples positive for VA1 by PCR (CDC_B and CDC_C) from the originally described outbreak of VA1-associated gastroenteritis in Virginia, USA, were used as the initial inoculum (23).”
BackgroundMethodInfluentialSelf-citationPérot, P., Lecuit, M., & Eloit, M. (2017) · Viruses · doi:10.3390/v9010010 · Cited by 43 · see citing works
“After the discovery of distant HAstV strains, MLB [16,63] and VA1/HMO-C [17], additional”
BackgroundBat Astroviruses: Towards Understanding the Transmission Dynamics of a Neglected Virus Family
Fischer, K., dos Reis, V. P., & Balkema-Buschmann, A. (2017) · Viruses · doi:10.3390/v9020034 · Cited by 42 · see citing works
“In a study where fecal samples from pigs and humans from several Colombian regions were collected, the authors assumed that recombination between the porcine and the human astroviruses within the variable region of ORF2 had occurred [59].”
BackgroundInfluentialA Systematic Approach to Novel Virus Discovery in Emerging Infectious Disease Outbreaks
Sridhar, S., To, K., Chan, J., Lau, S., Woo, P. C. Y., & Yuen, K. Y. (2015) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2014.12.002 · Cited by 42
New astrovirus in human feces from Burkina Faso
Phan, T., Nordgren, J., Ouermi, D., Simporé, J., Nitiéma, L., Deng, X.-T., & Delwart, E. (2014) · Journal of Clinical Virology · doi:10.1016/j.jcv.2014.03.024 · Cited by 42 · see citing works
“The fourth human astrovirus species (mamastrovirus 9), also described in 2009, includes strains VA1 [5], VA3 [6], HMO-B and HMO-C [4].”
BackgroundPorcine astrovirus viremia and high genetic variability in pigs on large holdings in Croatia.
Brnić, D., Prpić, J., Keros, T., Roić, B., Starešina, V., & Jemeršić, L. (2013) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.12.027 · Cited by 42 · see citing works
Identification of a second encephalitis-associated astrovirus in cattle
Seuberlich, T., Wüthrich, D., Selimovic-Hamza, S., Drögemüller, C., Oevermann, A., Bruggmann, R., & Bouzalas, I. (2016) · Emerging Microbes and Infections · doi:10.1038/emi.2016.5 · Cited by 40 · see citing works
Martella, V., Pinto, P., Tummolo, F., Grazia, S. D., Giammanco, G., Medici, M., Ganesh, B., L'Homme, Y., Farkas, T., Jakab, F., et al. (2014) · Archives of Virology · doi:10.1007/s00705-014-2153-9 · Cited by 40 · see citing works
“A number of unusual HAstVs discovered recently are genetically more closely related to animal AstVs than to ‘‘canonical’’ HAstVs [3, 16, 17, 26, 28, 39].”
BackgroundPativada, M., Nataraju, S. M., Ganesh, B., Rajendran, K., Ramamurthy, T., Ganguly, S., Bhattacharya, M., Ghosh, M., Kobayashi, N., & Krishnan, T. (2012) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.07.018 · Cited by 38 · see citing works
Novel Astroviruses in Children, Egypt
Ahmed, S. F., Sebeny, P., Klena, J., Pimentel, G., Mansour, A., Naguib, A., Bruton, J., Young, S. Y., Holtz, L. R., & Wang, D. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1712.110909 · Cited by 38 · see citing works
Self-citationHata, A., Kitajima, M., Haramoto, E., Lee, S., Ihara, M., Gerba, C., & Tanaka, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-30217-y · Cited by 37
Khamrin, P., Thongprachum, A., Okitsu, S., Hayakawa, S., Maneekarn, N., & Ushijima, H. (2016) · Journal of Medical Virology · doi:10.1002/jmv.24337 · Cited by 37 · see citing works
“After the discovery of novel astroviruses MLB and VA clades, the viruses have been reported as occurring in acute gastroenteritis pediatric patients globally, including several countries in Asia [Finkbeiner et al., 2008b, 2009b; Matsumoto et al., 2013].”
BackgroundMethodResultInfluentialHigh evolutionary rate of human astrovirus.
Babkin, I., Tikunov, A., Zhirakovskaia, E., Netesov, S., & Tikunova, N. (2012) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.01.019 · Cited by 37 · see citing works
Isolation and phylogenetic characterization of bat astroviruses in southern China
Xiao, J.-P., Li, J., Hu, G., Chen, Z., Wu, Y., Chen, Y., Chen, Z., Liao, Y., Zhou, J., Ke, X., et al. (2011) · Archives of Virology · doi:10.1007/s00705-011-1011-2 · Cited by 37 · see citing works
“Recently, two new astroviruses, astrovirus MLB1 and astrovirus VA1, were detected in patients with diarrhea [7, 8].”
BackgroundThe Expanding Field of Mammalian Astroviruses: Opportunities and Challenges in Clinical Virology.
Boujon, C. L., Koch, M., & Seuberlich, T. (2017) · Advances in Virus Research · doi:10.1016/bs.aivir.2017.07.002 · Cited by 37 · see citing works
Cordey, S., Brito, F., Vu, D., Turin, L., Kilowoko, M., Kyungu, E., Genton, B., Zdobnov, E., D'Acremont, V., & Kaiser, L. (2016) · Emerging Microbes and Infections · doi:10.1038/emi.2016.98 · Cited by 35
Update on SARS research and other possibly zoonotic coronaviruses
Anderson, L., & Tong, S. (2010) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2010.06.016 · Cited by 34
“Various other molecular tools have been developed and applied to samples from humans, and a number of novel viruses have been detected, including novel coronaviruses [54] [55] [56] , parvoviruses [57, 58] , polyomaviruses [59, 60] , astroviruses [61] and rhinoviruses [62] .”
BackgroundSelf-citationSurveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus
Xavier, M. D. P. T. P., Costa, F. A. C., Rocha, M., de Andrade, J. D. S. R., Diniz, F. B., de Andrade, T. R., Miagostovich, M., Leite, J. P., & Volotão, E. D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135687 · Cited by 33
From orphan virus to pathogen: the path to the clinical lab
Li, L., & Delwart, E. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.07.006 · Cited by 29 · see citing works
“Viral metagenomics was initially used to analyze environmental samples using Sanger shotgun sequencing [4], and has rapidly expanded to include samples such as human and animal feces [5–11], blood [12,13], tissues [14–17] and respiratory secretions [18–20] often using next generation sequencing.”
MethodBeyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses
Janowski, A. B. (2021) · Viruses · doi:10.3390/v13050732 · Cited by 35 · see citing works
Kumthip, K., Khamrin, P., Ushijima, H., & Maneekarn, N. (2018) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2018.08.024 · Cited by 32 · see citing works
Astrovirus infection in hospitalized children: Molecular, clinical and epidemiological features.
Siqueira, J. A., Oliveira, D. D. S., Carvalho, T. C. D. D., Portal, T. M., Justino, M. C., da Silva, L. D., Resque, H. R., & Gabbay, Y. (2017) · Journal of Clinical Virology · doi:10.1016/j.jcv.2017.07.014 · Cited by 32
The diversity of human RNA viruses
Woolhouse, M., & Adair, K. (2013) · Future Virology · doi:10.2217/fvl.12.129 · Cited by 32 · see citing works
Full-genome based molecular characterization of encephalitis-associated bovine astroviruses.
Bouzalas, I., Wüthrich, D., Selimovic-Hamza, S., Drögemüller, C., Bruggmann, R., & Seuberlich, T. (2016) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2016.06.052 · Cited by 31 · see citing works
“Some of them, such as HAstV MLB (MAstV 6), HAstV HMO-A (MAstV 8) and HAstV VA1 (MAstV 9) are novel genotype species and form previously unknown phylogenetic clades (Finkbeiner et al., 2008; Finkbeiner et al., 2009).”
BackgroundHata, A., Katayama, H., Kitajima, M., & Furumai, H. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.00563-15 · Cited by 31 · see citing works
“On the basis of the background presented above, we performed the present study to investigate the occurrence and genetic diversity of classic HAstVs as well as novel AstVs in wastewater in Japan.”
BackgroundInfluentialA Novel Astrovirus-Like RNA Virus Detected in Human Stool
Munnink, B. O., Cotten, M., Canuti, M., Deijs, M., Jebbink, M., van Hemert, F. V., Phan, M. V. T., Bakker, M., Farsani, S. M. J., Kellam, P., et al. (2016) · Virus Evolution · doi:10.1093/ve/vew005 · Cited by 29 · see citing works
“Two new clades of astroviruses have been described in stool samples from patients with diarrhoea (Finkbeiner, Kirkwood, and Wang 2008; Finkbeiner et al. 2009b).”
BackgroundA novel astrovirus from dromedaries in the Middle East.
Woo, P. C. Y., Lau, S., Teng, J. L. L., Tsang, A. K. L., Joseph, S., Xie, J., Jose, S., Fan, R. Y. Y., Wernery, U., & Yuen, K. Y. (2015) · Journal of General Virology · doi:10.1099/jgv.0.000233 · Cited by 29 · see citing works
“Novel human and animal AstVs have been discovered in recent years (Atkins et al., 2009; Chu et al., 2010; Finkbeiner et al., 2008, 2009; Hu et al., 2014; Kapoor et al., 2009; Luo et al., 2011; Martella et al., 2011a, b; Rivera et al., 2010; Smits et al., 2010; Stenglein et al., 2012).”
BackgroundDefining the Etiology of Diarrhea: Novel Approaches
Operario, D., & Houpt, E. (2011) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32834aa13a · Cited by 29 · see citing works
Zhao, G.-Y., Droit, L., Tesh, R., Popov, V., Little, N. S., Upton, C., Virgin, H., & Wang, D. (2011) · Journal of Virology · doi:10.1128/jvi.00637-11 · Cited by 29
Self-citationAfrad, M. H., Karmakar, P. C., Das, S., Matthijnssens, J., Ahmed, F., Nahar, S., Faruque, A. G., Rahman, M. Z., Rahman, M., & Azim, T. (2013) · Journal of Clinical Virology · doi:10.1016/j.jcv.2013.09.028 · Cited by 28
Environmental assessment reveals the presence of MLB‐1 human astrovirus in Uruguay
Lizasoain, A., Tort, L., García, M., Gómez, M. M., Leite, J. P. G., Miagostovich, M., Cristina, J., Colina, R., & Victoria, M. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12856 · Cited by 27 · see citing works
“Screening of the recently identified HAstV was carried out amplifying a 409 bp segment of the ORF1b region of the AstV genome with primers SF0073 and SF0076 designed with a bias for the detection of highly divergent HAstV (MLB and VA) (Finkbeiner et al. 2009c).”
BackgroundMethodInfluentialFirth, A., & Atkins, J. (2010) · Virology Journal · doi:10.1186/1743-422x-7-17 · Cited by 27 · see citing works
“[11] [12] [13] [14] for recent phylogenetic trees).”
Health conditions in rural areas with high livestock density: Analysis of seven consecutive years.
van Dijk, C. V., Zock, J., Baliatsas, C., Smit, L., Borlée, F., Spreeuwenberg, P., Heederik, D., & Yzermans, C. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2016.12.023 · Cited by 26 · see citing works
Advanced techniques for detection and identification of microbial agents of gastroenteritis.
Dunbar, S., Zhang, H., & Tang, Y.-W. (2013) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2013.03.003 · Cited by 26 · see citing works
Recently Identified Novel Human Astroviruses in Children with Diarrhea, China
Wang, Y.-X., Li, Y., Jin, Y., Li, D.-D., Li, X., & Duan, Z. (2013) · Emerging Infectious Diseases · doi:10.3201/eid1908.121863 · Cited by 26
Self-citationPhylogenetically diverse TT virus viremia among pregnant women.
Bzhalava, D., Ekström, J., Lysholm, F., Hultin, E., Faust, H., Persson, B., Lehtinen, M., de Villiers, E., & Dillner, J. (2012) · Virology · doi:10.1016/j.virol.2012.06.022 · Cited by 26
Neurotropic Astroviruses in Animals
Wildi, N., & Seuberlich, T. (2021) · Viruses · doi:10.3390/v13071201 · Cited by 25 · see citing works
“The HMO clade originally contained newly discovered astrovirus strains from humans (HuAstV VA1) [58] and mink feces samples (MiAstV, MAstV 10), which showed genetic similarity to OvAstV 1 (MAstV 13).”
BackgroundInfluentialYuan, X.-Y., Meng, K., Zhang, Y.-X., Qi, L.-H., Ai, W., & Wang, Y.-L. (2018) · Msphere · doi:10.1128/msphere.00380-18 · Cited by 23 · see citing works
- Authors
- Finkbeiner, S. R., Li, Y., Ruone, S., Conrardy, C., Gregoricus, N., Toney, D., Virgin, H. W., Anderson, L. J., Vinjé, J., Wang, D., & Tong, S.
- Affiliations
- Washington University in St. Louis (US)
- Centers for Disease Control and Prevention (US)
- Commonwealth of Virginia (US)
- Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
- Corresponding author
- Wang, David
- Tong, Suxiang
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2009-10-15
- Volume
- 83
- Issue
- 20
- Pages
- 10836-10839
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC2753140
- OpenAlex
- W2117058366
- Cited by
- 224
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 14 · 2018: 13 · 2017: 14 · 2016: 19 · 2015: 20 · 2014: 14 · 2013: 12 · 2012: 26
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- National Institutes of Health (AI057160)
- Centers for Disease Control and Prevention
- National Institute of Allergy and Infectious Diseases (U54AI057160)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- astrovirus, acute gastroenteritis, gastroenteritis outbreak, daycare centers, viral etiology, viral genome, phylogenetic analysis, fecal samples, RNA viruses
- MeSH terms
- Adult, Animals, Mamastrovirus, Child Day Care Centers, Child, Preschool, Disease Outbreaks, Feces, Female, Gastroenteritis, Genotype, Humans, Infant, Male, Molecular Sequence Data, Phylogeny, Species Specificity, Polymerase Chain Reaction, Sequence Analysis, DNA, Astroviridae Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
