Cited by 211HIV Research and TreatmentT-cell and Retrovirus StudiesHIV/AIDS drug development and treatment

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Requirement for an Intact T-Cell Actin and Tubulin Cytoskeleton for Efficient Assembly and Spread of Human Immunodeficiency Virus Type 1

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Jolly, Clare, Mitar, Ivonne, Sattentau, Quentin J.·2007·Journal of Virology

DOI 10.1128/jvi.01469-06PMC PMC1900271

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Abstract

Human immunodeficiency virus type 1 (HIV-1) infection of CD4 + T cells leads to the production of new virions that assemble at the plasma membrane. Gag and Env accumulate in the context of lipid rafts at the inner and outer leaflets of the plasma membrane, respectively, forming polarized domains from which HIV-1 buds. HIV-1 budding can result in either release of cell-free virions or direct cell-cell spread via a virological synapse (VS). The recruitment of Gag and Env to these plasma membrane caps in T cells is poorly understood but may require elements of the T-cell secretory apparatus coordinated by the cytoskeleton. Using fixed-cell immunofluorescence labeling and confocal microscopy, we observed a high percentage of HIV-1-infected T cells with polarized Env and Gag in capped, lipid raft-like assembly domains. Treatment of infected T cells with inhibitors of actin or tubulin remodeling disrupted Gag and Env compartmentalization within the polarized raft-like domains. Depolymerization of the actin cytoskeleton reduced Gag release and viral infectivity, and actin and tubulin inhibitors reduced Env incorporation into virions. Live- and fixed-cell confocal imaging and assay of de novo DNA synthesis by real-time PCR allowed quantification of HIV-1 cell-cell transfer. Inhibition of actin and tubulin remodeling in infected cells interfered with cell-cell spread across a VS and reduced new viral DNA synthesis. Based on these data, we propose that HIV-1 requires both actin and tubulin components of the T-cell cytoskeleton to direct its assembly and budding and to elaborate a functional VS.

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Self-citation
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Morita, E., & Sundquist, W. I. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.102350 · Cited by 594
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
Booth, A. M., Fang, Y., Fallon, J. K., Yang, J.-M., Hildreth, J. E. K., & Gould, S. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508014 · Cited by 562
Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane
Ono, A., Ablan, S. D., Lockett, S. J., Nagashima, K., & Freed, E. O. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405596101 · Cited by 553
Infectious HIV-1 assembles in late endosomes in primary macrophages
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Gouin, E., Welch, M. D., & Cossart, P. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.12.013 · Cited by 369
Evidence That HIV Budding in Primary Macrophages Occurs through the Exosome Release Pathway
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Microbial pathogenesis and cytoskeletal function
Gruenheid, S., & Finlay, B. B. (2003) · Nature · doi:10.1038/nature01603 · Cited by 296
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
Greene, W. C., & Peterlin, B. M. (2002) · Nature Medicine · doi:10.1038/nm0702-673 · Cited by 293
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Cell-Type-Dependent Targeting of Human Immunodeficiency Virus Type 1 Assembly to the Plasma Membrane and the Multivesicular Body
Ono, A., & Freed, E. O. (2004) · Journal of Virology · doi:10.1128/jvi.78.3.1552-1563.2004 · Cited by 275
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Bangham, C. R. M. (2003) · Journal of General Virology · doi:10.1099/vir.0.19334-0 · Cited by 262
Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1
Nydegger, S., Khurana, S., Krementsov, D. N., Foti, M., & Thali, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508165 · Cited by 257
Directed Egress of Animal Viruses Promotes Cell-to-Cell Spread
Johnson, D. C., & Huber, M. T. (2002) · Journal of Virology · doi:10.1128/jvi.76.1.1-8.2002 · Cited by 255
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Dong, X., Li, H., Derdowski, A., Ding, L., Burnett, A. S., Chen, X., Peters, T. R., Dermody, T. S., Woodruff, E. A., Wang, J.-J., et al. (2005) · Cell · doi:10.1016/j.cell.2004.12.023 · Cited by 245
Multimerization of Human Immunodeficiency Virus Type 1 Gag Promotes Its Localization to Barges, Raft-Like Membrane Microdomains
Lindwasser, O. W., & Resh, M. D. (2001) · Journal of Virology · doi:10.1128/jvi.75.17.7913-7924.2001 · Cited by 244
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Healey, D. G., Dianda, L., Moore, J. P., McDougal, J. S., Moore, M. J., Estess, P., Buck, D., Kwong, P. D., Beverley, P. C. L., & Sattentau, Q. J. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.4.1233 · Cited by 212
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Böge, M., Wyss, S., Bonifacino, J., & Thali, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15773 · Cited by 210
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Iyengar, S., Hildreth, J. E. K., & Schwartz, D. H. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.5251-5255.1998 · Cited by 203
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Frischknecht, F. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01871-7 · Cited by 197
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Serrador, J. M., Cabrero, J. R., Sancho, D., Mittelbrunn, M., Urzainqui, A., & Sánchez‐Madrid, F. (2004) · Immunity · doi:10.1016/s1074-7613(04)00078-0 · Cited by 193
Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity
Rousso, I. Y., Mixon, M. B., Chen, B. K., & Kim, P. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240459697 · Cited by 189
Cortical control of microtubule stability and polarization
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Nydegger, S., Foti, M., Derdowski, A., Spearman, P. W., & Thali, M. (2003) · Traffic · doi:10.1046/j.1600-0854.2003.00145.x · Cited by 185
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Phillips, D. M. (1994) · AIDS · doi:10.1097/00002030-199406000-00001 · Cited by 172
Assembly of Infectious HIV-1 in Human Epithelial and T-Lymphoblastic Cell Lines
Grigorov, B., Arcanger, F., Roingeard, P., Darlix, J., & Muriaux, D. M. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.04.017 · Cited by 161
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Perlman, M., & Resh, M. D. (2006) · Traffic · doi:10.1111/j.1398-9219.2006.00428.x · Cited by 160
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Self-citation
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Liu, B., Dai, R., Tian, C., Dawson, L., Gorelick, R. J., & Yu, X.-F. (1999) · Journal of Virology · doi:10.1128/jvi.73.4.2901-2908.1999 · Cited by 142
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Role of the cytoskeleton in cell-to-cell transmission of human immunodeficiency virus
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Myosin-actin interaction plays an important role in human immunodeficiency virus type 1 release from host cells.
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Deschambeault, J., Lalonde, J.-P., Cervantes-Acosta, G., Lodge, R., Cohen, É. A., & Lemay, G. (1999) · Journal of Virology · doi:10.1128/jvi.73.6.5010-5017.1999 · Cited by 111
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Fais, S., Capobianchi, M. R., Abbate, I., Castilletti, C., Gentile, M., Fei, P. C., Ameglio, F., & DIANZANI, F. (1995) · AIDS · doi:10.1097/00002030-199504000-00003 · Cited by 97
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Sancho, D., Vicente‐Manzanares, M., Mittelbrunn, M., Montoya, M. C., Gordón‐Alonso, M., Serrador, J. M., & Sánchez‐Madrid, F. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18908.x · Cited by 79
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Response of microtubules to the addition of colchicine and tubulin–colchicine: evaluation of models for the interaction of drugs with microtubules
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Authors: Jolly, C., Mitar, I., & Sattentau, Q. J.
Affiliations: University of Oxford (GB)
ORCID: Jolly, Clare
Sattentau, Quentin J.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2007-06
Volume: 81
Issue: 11
Pages: 5547-5560
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.01469-06
PMC: PMC1900271
OpenAlex: W2137870598
Cited by: 211
References: 66
Citations by year: 2025: 3 · 2024: 4 · 2023: 6 · 2022: 13 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 13 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 20 · 2013: 15 · 2012: 22
FWCI: 7.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institutes of Health
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: HIV-1, actin cytoskeleton, tubulin, virological synapse, cell-to-cell transmission, viral budding, Gag, Env, lipid rafts, actin depolymerization, tubulin polymerization inhibitors, CD4+ T cells, viral assembly
MeSH terms: Actins, Cell Communication, Cytoskeleton, Humans, T-Lymphocytes, Tubulin, HIV-1, HIV Infections, Virus Assembly, Jurkat Cells, Tubulin Modulators

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Requirement for an Intact T-Cell Actin and Tubulin Cytoskeleton for Efficient Assembly and Spread of Human Immunodeficiency Virus Type 1

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