The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex
Open accessAbstract
Human cytomegalovirus (HCMV) is a widely circulating pathogen that causes severe disease in immunocompromised patients and infected fetuses. By immortalizing memory B cells from HCMV-immune donors, we isolated a panel of human monoclonal antibodies that neutralized at extremely low concentrations (90% inhibitory concentration [IC 90 ] values ranging from 5 to 200 pM) HCMV infection of endothelial, epithelial, and myeloid cells. With the single exception of an antibody that bound to a conserved epitope in the UL128 gene product, all other antibodies bound to conformational epitopes that required expression of two or more proteins of the gH/gL/UL128-131A complex. Antibodies against gB, gH, or gM/gN were also isolated and, albeit less potent, were able to neutralize infection of both endothelial-epithelial cells and fibroblasts. This study describes unusually potent neutralizing antibodies against HCMV that might be used for passive immunotherapy and identifies, through the use of such antibodies, novel antigenic targets in HCMV for the design of immunogens capable of eliciting previously unknown neutralizing antibody responses.
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Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
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Self-citationIntegrin αvβ3 is a coreceptor for human cytomegalovirus
Wang, X., Huang, D. Y., Huong, S.-M., & Huang, E.-S. (2005) · Nature Medicine · doi:10.1038/nm1236 · Cited by 268
Gerna, G., Percivalle, E., Baldanti, F., Sozzani, S., Lanzarini, P., Genini, E., Lilleri, D., & Revello, M. G. (2000) · Journal of Virology · doi:10.1128/jvi.74.12.5629-5638.2000 · Cited by 171
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Cited by
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
Rappuoli, R., Bottomley, M. J., D’Oro, U., Finco, O., & De Gregorio, E. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151960 · Cited by 435
Antibodies to combat viral infections: development strategies and progress
Pantaleo, G., Correia, B., Fenwick, C., Joo, V. S., & Perez, L. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00495-3 · Cited by 279
John, S., Yuzhakov, O., Woods, A., Deterling, J., Hassett, K., Shaw, C. A., & Ciaramella, G. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.01.029 · Cited by 229
The history of vaccination against cytomegalovirus
Plotkin, S. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0388-z · Cited by 71
(2024) · doi:10.1073/pnas.2404250121 · Cited by 37
Metadata
- Authors
- Macagno, A., Bernasconi, N. L., Vanzetta, F., Dander, E., Sarasini, A., Revello, M. G., Gerna, G., Sallusto, F., & Lanzavecchia, A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2010-01-15
- Volume
- 84
- Issue
- 2
- Pages
- 1005-1013
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2127258151
- Cited by
- 326
- References
- 4
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Macagno, A., Bernasconi, N. L., Vanzetta, F., Dander, E., Sarasini, A., Revello, M. G., Gerna, G., Sallusto, F., & Lanzavecchia, A. (2010). Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex. Journal of Virology. https://doi.org/10.1128/jvi.01809-09
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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