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Cited by 218

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells

Open access
Chang, Jinhong, Guo, Ju-Tao, Jiang, Dong, Guo, Haitao, Taylor, John M., Block, Timothy M.·2008·Journal of Virology

Abstract

The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.

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Crossref · 10.1128/jvi.02575-07

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Metadata

Authors
Chang, J., Guo, J.-T., Jiang, D., Guo, H., Taylor, J. M., & Block, T. M.
Venue
Journal of Virology
Published
2008-08-15
Volume
82
Issue
16
Pages
8215-8223
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W2162449257
Cited by
218
References
6
FWCI
14.19
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells. https://app.cochat.ai/papers/10.1128/jvi.02575-07
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Chang, J., Guo, J.-T., Jiang, D., Guo, H., Taylor, J. M., & Block, T. M. (2008). Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells. Journal of Virology. https://doi.org/10.1128/jvi.02575-07

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.