The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections
Open accessAbstract
Interferons (IFNs) are key mediators of the host innate antiviral immune response. To identify IFN-stimulated genes (ISGs) that instigate an antiviral state against two medically important flaviviruses, West Nile virus (WNV) and dengue virus (DENV), we tested 36 ISGs that are commonly induced by IFN-α for antiviral activity against the two viruses. We discovered that five ISGs efficiently suppressed WNV and/or DENV infection when they were individually expressed in HEK293 cells. Mechanistic analyses revealed that two structurally related cell plasma membrane proteins, IFITM2 and IFITM3, disrupted early steps (entry and/or uncoating) of the viral infection. In contrast, three IFN-induced cellular enzymes, viperin, ISG20, and double-stranded-RNA-activated protein kinase, inhibited steps in viral proteins and/or RNA biosynthesis. Our results thus imply that the antiviral activity of IFN-α is collectively mediated by a panel of ISGs that disrupt multiple steps of the DENV and WNV life cycles.
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Interferon-inducible antiviral effectors
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The Interferon-Inducible Protein Viperin Inhibits Influenza Virus Release by Perturbing Lipid Rafts
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Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus
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Cited by
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
Interferon-stimulated genes and their antiviral effector functions
Schoggins, J. W., & Rice, C. M. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.10.008 · Cited by 1,289
The broad-spectrum antiviral functions of IFIT and IFITM proteins
Diamond, M. S., & Farzan, M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3344 · Cited by 849
IFITM3 restricts the morbidity and mortality associated with influenza
The GenISIS Investigators, Everitt, A. R., The MOSAIC Investigators, Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., Chin, C. R., Feeley, E. M., et al. (2012) · Nature · doi:10.1038/nature10921 · Cited by 782
Decoding type I and III interferon signalling during viral infection
Mesev, E. V., LeDesma, R. A., & Ploss, A. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0421-x · Cited by 538
Metadata
- Authors
- Jiang, D., Weidner, J. M., Qing, M., Pan, X.-B., Guo, H., Xu, C., Zhang, X., Birk, A., Chang, J., Shi, P.-Y., Block, T. M., & Guo, J.-T.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2010-08-15
- Volume
- 84
- Issue
- 16
- Pages
- 8332-8341
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2107380548
- Cited by
- 337
- References
- 59
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Jiang, D., Weidner, J. M., Qing, M., Pan, X.-B., Guo, H., Xu, C., Zhang, X., Birk, A., Chang, J., Shi, P.-Y., Block, T. M., & Guo, J.-T. (2010). Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections. Journal of Virology. https://doi.org/10.1128/jvi.02199-09
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