Cited by 202Mosquito-borne diseases and controlRNA Interference and Gene DeliverySARS-CoV-2 and COVID-19 Research

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

Open access
Kose, Nurgun, Fox, Julie M., Sapparapu, Gopal, Bombardi, Robin, Tennekoon, Rashika N., de Silva, A. Dharshan, Elbashir, Sayda M., Theisen, Matthew A. +5 more·2019·Science Immunology

Abstract

Lipid nanoparticles containing mRNA encoding a human antibody for chikungunya virus protect against infection and arthritis.

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Crossref · 10.1126/sciimmunol.aaw6647

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  • mRNA therapeutics encoding neutralizing monoclonal antibodies may have both prophylactic and therapeutic activity.

    “Interestingly, these results suggest that mRNA therapeutics encoding neutralizing mAbs may have both prophylactic and therapeutic activity.”
  • Moderna delivered mRNA encoding the monoclonal antibody CHKV-24 4 h after chikungunya virus inoculation and protected mice from chikungunya virus-induced arthritis.

    “Using a similar approach, Moderna successfully delivered mRNA encoding the mAb CHKV-24, 4 h after chikungunya virus inoculation and protected mice from chikungunya virus-induced arthritis158.”

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Authors
Kose, N., Fox, J. M., Sapparapu, G., Bombardi, R., Tennekoon, R. N., de Silva, A. D., Elbashir, S. M., Theisen, M. A., Humphris-Narayanan, E., Ciaramella, G., Himansu, S., Diamond, M. S., & Crowe, J. E.
Affiliations
  • Vanderbilt University Medical Center (US)
  • Washington University in St. Louis (US)
  • Genetech (Sri Lanka) (LK)
  • Genetech Research Institute, Colombo, Sri Lanka.
  • Moderna Therapeutics (United States) (US)
  • Moderna Therapeutics, Cambridge, MA, USA.
Corresponding author
Crowe, James E.
Venue
Science Immunology
Published
2019-05-24
Volume
4
Issue
35
ISSN
2470-9468 (ISSN-L)
OpenAlex
W2946690483
Cited by
202
References
52
Citations by year
2026: 15 · 2025: 19 · 2024: 24 · 2023: 25 · 2022: 32 · 2021: 43 · 2020: 40 · 2019: 4
FWCI
27.39
Type
journal article
Language
en
Open access
Locations
  • Science Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (R01 AI114816)
  • Defense Advanced Research Projects Agency (W911NF-13-1-0417)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
chikungunya virus, neutralizing monoclonal antibodies, mRNA vaccines, lipid nanoparticles, antibody therapy, viremia, macaque model, B cells, dose-response relationship
MeSH terms
Animals, Antibodies, Monoclonal, Antibodies, Viral, B-Lymphocytes, Cell Line, Chikungunya virus, Disease Models, Animal, Female, Cricetinae, Humans, Immunoglobulin G, Lipids, Macaca, Male, Mice, Inbred C57BL, RNA, Messenger, Mice, Nanocapsules, Antibodies, Neutralizing, Chikungunya Fever

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