A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
Open accessAbstract
Lipid nanoparticles containing mRNA encoding a human antibody for chikungunya virus protect against infection and arthritis.
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mRNA therapeutics encoding neutralizing monoclonal antibodies may have both prophylactic and therapeutic activity.
“Interestingly, these results suggest that mRNA therapeutics encoding neutralizing mAbs may have both prophylactic and therapeutic activity.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [158]
Moderna delivered mRNA encoding the monoclonal antibody CHKV-24 4 h after chikungunya virus inoculation and protected mice from chikungunya virus-induced arthritis.
“Using a similar approach, Moderna successfully delivered mRNA encoding the mAb CHKV-24, 4 h after chikungunya virus inoculation and protected mice from chikungunya virus-induced arthritis158.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [158]
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- Authors
- Kose, N., Fox, J. M., Sapparapu, G., Bombardi, R., Tennekoon, R. N., de Silva, A. D., Elbashir, S. M., Theisen, M. A., Humphris-Narayanan, E., Ciaramella, G., Himansu, S., Diamond, M. S., & Crowe, J. E.
- Affiliations
- Vanderbilt University Medical Center (US)
- Washington University in St. Louis (US)
- Genetech (Sri Lanka) (LK)
- Genetech Research Institute, Colombo, Sri Lanka.
- Moderna Therapeutics (United States) (US)
- Moderna Therapeutics, Cambridge, MA, USA.
- Corresponding author
- Crowe, James E.
- ORCID
- Venue
- Science Immunology
- Published
- 2019-05-24
- Volume
- 4
- Issue
- 35
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC6629435
- OpenAlex
- W2946690483
- Cited by
- 202
- References
- 52
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 24 · 2023: 25 · 2022: 32 · 2021: 43 · 2020: 40 · 2019: 4
- FWCI
- 27.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI114816)
- Defense Advanced Research Projects Agency (W911NF-13-1-0417)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- chikungunya virus, neutralizing monoclonal antibodies, mRNA vaccines, lipid nanoparticles, antibody therapy, viremia, macaque model, B cells, dose-response relationship
- MeSH terms
- Animals, Antibodies, Monoclonal, Antibodies, Viral, B-Lymphocytes, Cell Line, Chikungunya virus, Disease Models, Animal, Female, Cricetinae, Humans, Immunoglobulin G, Lipids, Macaca, Male, Mice, Inbred C57BL, RNA, Messenger, Mice, Nanocapsules, Antibodies, Neutralizing, Chikungunya Fever
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