The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Antibody-Dependent Cellular Cytotoxicity Is Associated with Control of Pandemic H1N1 Influenza Virus Infection of Macaques
Open accessAbstract
Emerging influenza viruses pose a serious risk to global human health. Recent studies in ferrets, macaques, and humans suggest that seasonal H1N1 (sH1N1) infection provides some cross-protection against 2009 pandemic influenza viruses (H1N1pdm), but the correlates of cross-protection are poorly understood. Here we show that seasonal infection of influenza-naïve Indian rhesus macaques ( Macaca mulatta ) with A/Kawasaki/173/2001 (sH1N1) virus induces antibodies capable of binding the hemagglutinin (HA) of both the homologous seasonal virus and the antigenically divergent A/California/04/2009 (H1N1pdm) strain in the absence of detectable H1N1pdm-specific neutralizing antibodies. These influenza virus-specific antibodies activated macaque NK cells to express both CD107a and gamma interferon (IFN-γ) in the presence of HA proteins from either sH1N1 or H1N1pdm viruses. Although influenza virus-specific antibody-dependent cellular cytotoxicity (ADCC)-mediated NK cell activation diminished in titer over time following sH1N1 infection, these cells expanded rapidly within 7 days following H1N1pdm exposure. Furthermore, we found that influenza virus-specific ADCC was present in bronchoalveolar lavage fluid and was able to activate lung NK cells. We concluded that infection with a seasonal influenza virus can induce antibodies that mediate ADCC capable of recognizing divergent influenza virus strains. Cross-reactive ADCC may provide a mechanism for reducing the severity of divergent influenza virus infections.
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DiLillo, D. J., Tan, G. S., Palese, P., & Ravetch, J. V. (2014) · Nature Medicine · doi:10.1038/nm.3443 · Cited by 749
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Metadata
- Authors
- Jegaskanda, S., Weinfurter, J. T., Friedrich, T. C., & Kent, S. J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2013-05-15
- Volume
- 87
- Issue
- 10
- Pages
- 5512-5522
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2032809145
- Cited by
- 183
- References
- 5
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jegaskanda, S., Weinfurter, J. T., Friedrich, T. C., & Kent, S. J. (2013). Antibody-Dependent Cellular Cytotoxicity Is Associated with Control of Pandemic H1N1 Influenza Virus Infection of Macaques. Journal of Virology. https://doi.org/10.1128/jvi.03030-12
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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