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Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins
Open accessAbstract
Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is determined predominantly by their dynamic adaptation capacities when confronted with different selective pressures in an endless cycle of coevolution with a widespread group of bacterial hosts. At the end of the infection cycle, progeny virions are confronted with a rigid cell wall that hinders their release into the environment and the opportunity to start a new infection cycle. Consequently, phages encode hydrolytic enzymes, called endolysins, to digest the peptidoglycan. In this work, we bring to light all phage endolysins found in completely sequenced double-stranded nucleic acid phage genomes and uncover clues that explain the phage-endolysin-host ecology that led phages to recruit unique and specialized endolysins.
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Cahill, J., & Young, R. (2019) · Advances in Virus Research · doi:10.1016/bs.aivir.2018.09.003 · Cited by 319
Zheng, W., Tan, M. F., Old, L. A., Paterson, I. C., Jakubovics, N. S., & Choo, S. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-02399-4 · Cited by 34
SPAED: harnessing AlphaFold output for accurate segmentation of phage endolysin domains
Boulay, A., Cremelie, E., Galiez, C., Briers, Y., Rousseau, E., & Vázquez, R. (2025) · Bioinformatics · doi:10.1093/bioinformatics/btaf531 · Cited by 4
Metadata
- Authors
- Oliveira, H., Melo, L. D. R., Santos, S. B., Nóbrega, F. L., Ferreira, E. C., Cerca, N., Azeredo, J., & Kluskens, L. D.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2013-04-15
- Volume
- 87
- Issue
- 8
- Pages
- 4558-4570
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2026292570
- Cited by
- 288
- References
- 80
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Oliveira, H., Melo, L. D. R., Santos, S. B., Nóbrega, F. L., Ferreira, E. C., Cerca, N., Azeredo, J., & Kluskens, L. D. (2013). Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins. Journal of Virology. https://doi.org/10.1128/jvi.03277-12
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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