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Identification of a transforming gene of human papillomavirus type 16
Abstract
Previously, we observed sequential two-step alteration, growth stimulation, and progression to a more malignant state in NIH 3T3 cells transfected by human papillomavirus type 16 (HPV-16) DNA. In this study, we prepared a cDNA library from RNA extracted from cells transfected with the HPV-16 DNA and isolated cDNA clones which had growth-stimulating activity. Analysis of these cDNA clones indicated that the E7 open reading frame alone is responsible for inducing both steps of this cell transformation.
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“subsequently, E7 was recognized as the major transforming protein of high-risk HPVs, using mutational analyses in transformation assays [52,79,80,81,82,83,84]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [81]
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Research works printed but not linked: 8
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Cited by
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Tanaka, A., Noda, T., Yajima, H., Hatanaka, M., & Ito, Y.
- Affiliations
- Institute for Virus Research, Kyoto University, Japan.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1989-03
- Volume
- 63
- Issue
- 3
- Pages
- 1465-1469
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 58
- References
- 0
- Language
- en
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- Tanaka, A., Noda, T., Yajima, H., Hatanaka, M., & Ito, Y. (1989). Identification of a transforming gene of human papillomavirus type 16. Journal of Virology. https://doi.org/10.1128/jvi.63.3.1465-1469.1989
