Cited by 1,050Immunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

Chen, Lieping, Ashe, Stephanie, Brady, William A., Hellström, Ingegerd, Hellström, Karl Erik, Ledbetter, Jeffrey A., McGowan, Patrick, Linsley, Peter S.·1992·Cell

Abstract

Interaction of the B7 molecule on antigen-presenting cells with its receptors CD28 and CTLA-4 on T cells provides costimulatory signals for T cell activation. We have studied the effects of B7 on antitumor immunity to a murine melanoma that expresses a rejection antigen associated with the E7 gene product of human papillomavirus 16. While this E7+ tumor grows progressively in immunocompetent hosts, cotransfection of its cells with B7 led to tumor regression by a B7-dependent immune response mediated by CD8+ cytolytic T lymphocytes. The immune response induced by E7+B7+ tumor cells also caused regression of E7+B7- tumors at distant sites and was curative for established E7+B7- micrometastases. Our findings suggest that increasing T cell costimulation through the CD28 and CTLA-4 receptors may have therapeutic usefulness for generating immunity against tumors expressing viral antigens.

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Crossref · 10.1016/s0092-8674(05)80059-5

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52 of 52 references verified0 citation errors · 0 not checkable

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  • In animal models, introducing B7-1 into tumors or blocking inhibitory B7 family members reduces tumor growth or causes spontaneous tumor rejection.

    “Animal model studies have shown that introduction of B7-1 into tumors by transfection or blockade of inhibitory B7 family members can reduce tumor growth or result in spontaneous tumor rejection in vivo [7–13].”

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Authors
Chen, L., Ashe, S., Brady, W. A., Hellström, I., Hellström, K. E., Ledbetter, J. A., McGowan, P., & Linsley, P. S.
Affiliations
Bristol-Myers Squibb (United States) (US)
Venue
Cell
Publisher
Elsevier BV
Published
1992-12
Volume
71
Issue
7
Pages
1093-1102
ISSN
0092-8674 (ISSN-L)
OpenAlex
W1978416272
Cited by
1,050
References
52
Citations by year
2026: 2 · 2025: 3 · 2024: 10 · 2023: 10 · 2022: 7 · 2021: 2 · 2020: 15 · 2019: 18 · 2018: 13 · 2017: 12 · 2016: 5 · 2015: 17 · 2014: 9 · 2013: 13 · 2012: 8
FWCI
30.73
Type
journal article
Language
en
Open access
closed
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
B7 costimulation, CD28, CTLA-4, T cell costimulation, antitumor immunity, murine melanoma, tumor regression, micrometastases, antigen-presenting cells
MeSH terms
Abatacept, Animals, Antigens, Differentiation, Antigens, Differentiation, T-Lymphocyte, Antigens, Surface, Antigens, Viral, Cell Line, Female, Lymphocyte Activation, Mice, Inbred C3H, Neoplasm Regression, Spontaneous, Neoplasms, Experimental, T-Lymphocytes, Cytotoxic, Transfection, Antigens, CD, CD28 Antigens, Immunoconjugates, Mice, CTLA-4 Antigen

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