The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein
Open accessAbstract
We present a novel mechanism by which viruses may inhibit the alpha/beta interferon (IFN-α/β) cascade. The double-stranded RNA (dsRNA) binding protein NS1 of influenza virus is shown to prevent the potent antiviral interferon response by inhibiting the activation of interferon regulatory factor 3 (IRF-3), a key regulator of IFN-α/β gene expression. IRF-3 activation and, as a consequence, IFN-β mRNA induction are inhibited in wild-type (PR8) influenza virus-infected cells but not in cells infected with an isogenic virus lacking the NS1 gene (delNS1 virus). Furthermore, NS1 is shown to be a general inhibitor of the interferon signaling pathway. Inhibition of IRF-3 activation can be achieved by the expression of wild-type NS1 in trans , not only in delNS1 virus-infected cells but also in cells infected with a heterologous RNA virus (Newcastle disease virus). We propose that inhibition of IRF-3 activation by a dsRNA binding protein significantly contributes to the virulence of influenza A viruses and possibly to that of other viruses.
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Cites
Lin, R., Heylbroeck, C., Pitha, P. M., & Hiscott, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2986 · Cited by 915 · cited 3×
“Several groups have demonstrated that a hallmark of IRF-3 activation in virus-infected cells is its nuclear accumulation (22, 38).”
BackgroundWathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80051-9 · Cited by 730
Cited by
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-06 · Cited by 818
The dsRNA protein kinase PKR: Virus and cell control
García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
Levy, D. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00027-7 · Cited by 428
Influenza virus targets the mRNA export machinery and the nuclear pore complex
Satterly, N., Tsai, P.-L., van Deursen, J., Nussenzveig, D. R., Wang, Y., Faria, P. A., Levay, A., Levy, D. E., & Fontoura, B. M. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610977104 · Cited by 286
Rajsbaum, R., Versteeg, G. A., Schmid, S., Maestre, A. M., Belicha-Villanueva, A., Martínez-Romero, C., Patel, J. R., Morrison, J., Pisanelli, G., Miorin, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.018 · Cited by 168
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Metadata
- Authors
- Talon, J., Horvath, C. M., Polley, R., Basler, C. F., Muster, T., Palese, P., & García-Sastre, A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-09
- Volume
- 74
- Issue
- 17
- Pages
- 7989-7996
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1977457899
- Cited by
- 577
- References
- 2
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Talon, J., Horvath, C. M., Polley, R., Basler, C. F., Muster, T., Palese, P., & García-Sastre, A. (2000). Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein. Journal of Virology. https://doi.org/10.1128/jvi.74.17.7989-7996.2000
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
