Diversity of oxytocin neurones: Beyond magno‐ and parvocellular cell types?
Abstract
The hypothalamic neuropeptide oxytocin ( OT ), which is evolutionarily conserved among different species throughout the animal kingdom, is a key modulator of a variety of socio‐emotional behaviours such as fear, trust and empathy. OT cells in the mammalian hypothalamus have been traditionally divided into two distinct types: agnocellular (magn OT ) and parvocellular (parv OT ) or preautonomic neurones. This distinction is based on OT cell sizes and shapes, projections, electrophysiological activity and functions. Indeed, although neuroendocrine magn OT neurones are known to primarily project their axons to the posterior pituitary and to a number of forebrain regions, non‐neuroendocrine parv OT neurones have been seen as the main source of OT innervation of the brainstem and spinal cord to control autonomic functions and pain perception. However, very recent findings have demonstrated distinct genetic profiles in OT neurones, allowing the discrimination of at least four types of cells expressing OT . Furthermore, unexpected axonal projections of parv OT neurones to the forebrain and magn OT neurones to the midbrain have been newly reported. In this review, we focus on the detailed analysis of methods of distinction between OT cell types, in‐ and output sites, and morphology, as well as on the direct connectivity between OT neurones and its physiological significance. Finally, we propose a hypothesis suggesting that the central OT system is composed of more than just two OT cell types, which needs to be confirmed by the application of available genetic and anatomical techniques.
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Suckling triggers the release of oxytocin.
“Suckling triggers the release of oxytocin, but other sensory cues—specifically, infant cries—can increase the levels of oxytocin in new human mothers7”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [1]
Oxytocin is important for maternal physiology and childcare, including parturition and milk ejection during nursing.
“Oxytocin is a neuropeptide that is important for maternal physiology and childcare, including parturition and milk ejection during nursing1–6.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [1]
Oxytocin is produced mainly in the paraventricular nucleus and supraoptic nucleus of the hypothalamus.
“oxytocin, a nine-amino-acid peptide that is produced mainly in the paraventricular nucleus (PVN) and supraoptic nucleus of the hypothalamus1–4”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [1]
Parvocellular neurons can directly activate magnocellular neurons and have been proposed to operate as master cells that control the activity of magnocellular cells and gate oxytocin release.
“Parvocellular neurons can also directly activate magnocellular neurons and have been proposed to operate as ‘master cells’ that control the activity of magnocellular cells and gate oxytocin release1,13.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [1]
Cites
Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991 · see citing works
Swanson, L. W., & Kuypers, H. G. J. M. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901940306 · Cited by 1,413 · see citing works
The Central Nervous System of Vertebrates
Nieuwenhuys, R., ten Donkelaar, H. J., & Nicholson, C. (1998) · doi:10.1007/978-3-642-18262-4 · Cited by 1,249 · see citing works
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049 · see citing works
Self-citationOxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
Paraventricular Nucleus:A Site for the Integration of Neuroendocrine and Autonomic Mechanisms
Swanson, L. W., & Sawchenko, P. E. (2008) · Neuroendocrinology · doi:10.1159/000123111 · Cited by 1,001 · see citing works
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine
Gomez, J. L., Bonaventura, J., Lesniak, W., Mathews, W. B., Sysa-Shah, P., Rodriguez, L. A., Ellis, R. J., Richie, C. T., Harvey, B. K., Dannals, R. F., et al. (2017) · Science · doi:10.1126/science.aan2475 · Cited by 980 · see citing works
Deconstruction of a neural circuit for hunger
Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
Fluoro-gold: a new fluorescent retrograde axonal tracer with numerous unique properties
Schmued, L. C., & Fallon, J. H. (1986) · Brain Research · doi:10.1016/0006-8993(86)91199-6 · Cited by 887 · see citing works
Synthesis, transport, and release of posterior pituitary hormones
Brownstein, M. J., Russell, J. T., & Gainer, H. (1980) · Science · doi:10.1126/science.6153132 · Cited by 838 · see citing works
Locus coeruleus and dopaminergic consolidation of everyday memory
Takeuchi, T., Duszkiewicz, A. J., Sonneborn, A., Spooner, P. A., Yamasaki, M., Watanabe, M., Smith, C. C., Fernández, G., Deisseroth, K., Greene, R. W., et al. (2016) · Nature · doi:10.1038/nature19325 · Cited by 827 · see citing works
Oxytocin enables maternal behaviour by balancing cortical inhibition
Marlin, B. J., Mitre, M., D’amour, J. A., Chao, M. V., & Froemke, R. C. (2015) · Nature · doi:10.1038/nature14402 · Cited by 744 · see citing works
Neuroendocrine control of food intake
Valassi, E., Scacchi, M., & Cavagnini, F. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.06.004 · Cited by 649 · see citing works
Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L. J., Onaka, T., & Nishimori, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5593-08.2009 · Cited by 608 · see citing works
Katz, L. C., Burkhalter, A., & Dreyer, W. J. (1984) · Nature · doi:10.1038/310498a0 · Cited by 605 · see citing works
Gating of social reward by oxytocin in the ventral tegmental area
Hung, L. W., Neuner, S., Polepalli, J. S., Beier, K. T., Wright, M., Walsh, J. J., Lewis, E. M., Luo, L., Deisseroth, K., Dölen, G., et al. (2017) · Science · doi:10.1126/science.aan4994 · Cited by 578 · see citing works
Rhodes, C. H., Morriell, J. I., & Pfaff, D. W. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980106 · Cited by 536 · see citing works
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov, R. A., Zeisel, A., Bakker, J., Girach, F., Hellysaz, A., Tomer, R., Alpár, A., Mulder, J., Clotman, F., Keimpema, E., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4462 · Cited by 502 · see citing works
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439 · see citing works
Eliava, M., Melchior, M., Knobloch-Bollmann, H. S., Wahis, J., da Silva Gouveia, M., Tang, Y., Ciobanu, A. C., Triana del Rio, R., Roth, L. C., Althammer, F., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.041 · Cited by 409 · see citing works
Self-citationMorphology of vasopressin and oxytocin neurones and their central and vascular projections
Sofroniew, M. V. (1983) · Progress in Brain Research · doi:10.1016/s0079-6123(08)64378-2 · Cited by 370 · see citing works
Oxytocin–dopamine interactions mediate variations in maternal behavior in the rat
Shahrokh, D. K., Zhang, T.-Y., Diorio, J., Gratton, A., & Meaney, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-1271 · Cited by 366 · see citing works
Oxytocin enhances social recognition by modulating cortical control of early olfactory processing
Oettl, L.-L., Ravi, N., Schneider, M., Scheller, M. F., Schneider, P., Mitre, M., da Silva Gouveia, M., Froemke, R. C., Chao, M. V., Young, W. S., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.033 · Cited by 359 · see citing works
Self-citationGene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System
Burbach, J. P. H., Luckman, S. M., Murphy, D., & Gainer, H. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1197 · Cited by 338 · see citing works
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332 · see citing works
Lafon, M. (2005) · Journal of NeuroVirology · doi:10.1080/13550280590900427 · Cited by 328 · see citing works
Physiological pathways regulating the activity of magnocellular neurosecretory cells
Leng, G., Brown, C. H., & Russell, J. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00072-0 · Cited by 312 · see citing works
Kovacs, K., & Sawchenko, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00262.1996 · Cited by 310 · see citing works
Assembling the puzzle: pathways of oxytocin signaling in the brain
Grinevich, V., Knobloch-Bollmann, H. S., Eliava, M., Busnelli, M., & Chini, B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.013 · Cited by 309 · see citing works
Characterization of the oxytocin system regulating affiliative behavior in female prairie voles
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.055 · Cited by 309 · see citing works
Interaction of the Rabies Virus P Protein with the LC8 Dynein Light Chain
Raux, H., Flamand, A., & Blondel, D. (2000) · Journal of Virology · doi:10.1128/jvi.74.21.10212-10216.2000 · Cited by 297 · see citing works
Biased Oxytocinergic Modulation of Midbrain Dopamine Systems
Xiao, L., Priest, M. F., Nasenbeny, J., Lu, T., & Kozorovitskiy, Y. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.003 · Cited by 292 · see citing works
Vandesande, F., Dierickx, K., & Mey, J. D. (1977) · Cell and Tissue Research · doi:10.1007/bf00220167 · Cited by 270 · see citing works
中井, 茂., Kawano, H., Yudate, T., Nishi, M., Kuno, J., Nagata, A., Jishage, K., Hamada, H., Fujii, H., & Kawamura, K. (1995) · Genes & Development · doi:10.1101/gad.9.24.3109 · Cited by 263 · see citing works
Evolution of oxytocin pathways in the brain of vertebrates
Knobloch, H. S., & Grinevich, V. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00031 · Cited by 259 · see citing works
Self-citationMorphological and electrophysiological classification of hypothalamic supraoptic neurons
Armstrong, W. E. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)80005-s · Cited by 246 · see citing works
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 240 · see citing works
Tasker, J. G., & Dudek, F. E. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018469 · Cited by 233 · see citing works
Emergent Synchronous Bursting of Oxytocin Neuronal Network
Rossoni, E., Feng, J., Tirozzi, B., Brown, D., Leng, G., & Moos, F. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000123 · Cited by 207 · see citing works
Pagani, J. H., Zhao, M., Cui, Z., Williams Avram, S. K., Caruana, D. A., Dudek, S. M., & Young, W. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.47 · Cited by 204 · see citing works
NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation
Riddle, D. R., Lo, D. C., & Katz, L. C. (1995) · Nature · doi:10.1038/378189a0 · Cited by 200 · see citing works
Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain
Meddle, S. L., Bishop, V. R., Gkoumassi, E., van Leeuwen, F. W., & Douglas, A. J. (2007) · Endocrinology · doi:10.1210/en.2007-0615 · Cited by 195 · see citing works
Fliers, E., Swaab, D. F., W. Pool, C., & Verwer, R. W. H. (1985) · Brain Research · doi:10.1016/0006-8993(85)91351-4 · Cited by 190 · see citing works
Oxytocin-induced penile erection and yawning: site of action in the brain
Melis, M. R., Argiolas, A., & Gessa, G. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)91485-x · Cited by 190 · see citing works
Brain oxytocin in social fear conditioning and its extinction: involvement of the lateral septum
Zoicas, I., Slattery, D. A., & Neumann, I. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.156 · Cited by 189 · see citing works
Vasopressin and oxytocin—their role in neurotransmission
Buijs, R. M. (1983) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(83)90056-6 · Cited by 189 · see citing works
Human pigmentation genetics: the difference is only skin deep
Sturm, R. A., Box, N. F., & Ramsay, M. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199809)20:9 · Cited by 188 · see citing works
Oxytocin and Pain: A Systematic Review and Synthesis of Findings
Rash, J. A., Aguirre-Camacho, A., & Campbell, T. S. (2014) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31829f57df · Cited by 175 · see citing works
Development of the neuroendocrine hypothalamus
Markakis, E. A. (2002) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00003-1 · Cited by 174 · see citing works
Stern, J. E. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0161k.x · Cited by 173 · see citing works
Emotional Stress Triggers Intrahypothalamic But Not Peripheral Release of Oxytocin in Male Rats
Engelmann, Ebner, Landgraf, Holsboer, & Wotjak (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00403.x · Cited by 170 · see citing works
Neurotransmitters and peptides: Whispered secrets and public announcements
Leng, G., & Ludwig, M. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159103 · Cited by 168 · see citing works
ten Donkelaar, H. J. (2011) · Springer eBooks · doi:10.1007/978-3-642-19134-3 · Cited by 162 · see citing works
Novel designer receptors to probe GPCR signaling and physiology
Wess, J., Nakajima, K., & Jain, S. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.006 · Cited by 158 · see citing works
Herget, U., Wolf, A., Wullimann, M. F., & Ryu, S. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23480 · Cited by 158 · see citing works
Nassi, J. J., Cepko, C. L., Born, R. T., & Beier, K. T. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00080 · Cited by 156 · see citing works
Freeman, S. M., Walum, H., Inoue, K., Smith, A. L., Goodman, M. M., Bales, K. L., & Young, L. J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.055 · Cited by 153 · see citing works
Dierickx, K., & Vandesande, F. (1977) · Cell and Tissue Research · doi:10.1007/bf00220524 · Cited by 150 · see citing works
Oxytocin, feeding, and satiety
Sabatier, N., Leng, G., & Menzies, J. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00035 · Cited by 149 · see citing works
Chapter 22 Cardiovascular effects of oxytocin
Petersson, M. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39024-1 · Cited by 147 · see citing works
The action radius of oxytocin release in the mammalian CNS: from single vesicles to behavior
Chini, B., Verhage, M., & Grinevich, V. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.08.005 · Cited by 141 · see citing works
Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus
Peters, J. H., McDougall, S. J., Kellett, D. O., Jordan, D., Llewellyn-Smith, I. J., & Andresen, M. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3419-08.2008 · Cited by 135 · see citing works
Paraventricular oxytocin neurons are involved in neural modulation of breathing
Mack, S. O., Kc, P., Wu, M., Coleman, B. R., Tolentino-Silva, F. P., & Haxhiu, M. A. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00839.2001 · Cited by 132 · see citing works
<scp>O</scp>xytocin modulation of neural circuits for social behavior
Marlin, B. J., & Froemke, R. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22452 · Cited by 130 · see citing works
Distinct preoptic‐BST nuclei dissociate paternal and infanticidal behavior in mice
Tsuneoka, Y., Tokita, K., Yoshihara, C., Amano, T., Esposito, G., Huang, A. J. Y., Yu, L. M. Y., Odaka, Y. S., Shinozuka, K., McHugh, T. J., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591942 · Cited by 129 · see citing works
The orgasmic history of oxytocin: Love, lust, and labor
Magon, N., & Kalra, S. (2011) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.84851 · Cited by 127 · see citing works
Putative isotocin distributions in sonic fish: Relation to vasotocin and vocal–acoustic circuitry
Goodson, J. L., Evans, A. K., & Bass, A. H. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10679 · Cited by 126 · see citing works
Fink, G., Robinson, I. C., & Tannahill, L. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017165 · Cited by 121 · see citing works
Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders
Grinevich, V., Desarménien, M. G., Chini, B., Tauber, M., & Muscatelli, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00164 · Cited by 121 · see citing works
Self-citationJourdain, P., Israël, J.-M., Dupouy, B., Oliet, S. H. R., Michèle Allard, A., Vitiello, S., Theodosis, D. T., & Poulain, D. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06641.1998 · Cited by 118 · see citing works
Nawaratne, V., Leach, K., Suratman, N., Loiacono, R. E., Felder, C. C., Armbruster, B. N., Roth, B. L., Sexton, P. M., & Christopoulos, A. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.049353 · Cited by 112 · see citing works
Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development
Mathieu, J., Barth, A., Rosa, F., Wilson, S. W., & Peyriéras, N. (2002) · Development · doi:10.1242/dev.129.13.3055 · Cited by 104 · see citing works
Venkatesh, B., Si-Hoe, S. L., Murphy, D., & Brenner, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12462 · Cited by 103 · see citing works
Distribution of oxytocin in the brain of a eusocial rodent
Rosen, G. J., de Vries, G. J., Goldman, S. L., Goldman, B. D., & Forger, N. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.039 · Cited by 102 · see citing works
Lechan, R. M., Nestler, J. L., Jacobson, S., et al. (1980) · Brain Research · doi:10.1016/0006-8993(80)90862-8 · Cited by 101 · see citing works
Juif, P.-E., & Poisbeau, P. (2013) · Pain · doi:10.1016/j.pain.2013.05.003 · Cited by 101 · see citing works
Calcium-channel subtypes in the somata and axon terminals of magnocellular neurosecretory cells
Fisher, T. E. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10034-5 · Cited by 95 · see citing works
Interactions between dopamine and oxytocin in the control of sexual behaviour
Baskerville, T., & Douglas, A. S. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00423-8 · Cited by 93 · see citing works
Wierda, M., Goudsmit, E., Van Der Woude, P. F., Purba, J. S., Hofman, M. A., Bogte, H., & Swaab, D. F. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90081-t · Cited by 92 · see citing works
Calcagnoli, F., de Boer, S. F., Beiderbeck, D. I., Althaus, M., Koolhaas, J. M., & Neumann, I. D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.050 · Cited by 84 · see citing works
Differential projections of dorsal raphe nucleus neurons to the lateral septum and striatum
Waselus, M., Galvez, J. P., Valentino, R. J., & Bockstaele, E. J. V. (2006) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2006.01.007 · Cited by 83 · see citing works
Silencing Synapses with DREADDs
Zhu, H., & Roth, B. L. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.002 · Cited by 77 · see citing works
Tribollet, E., Barberis, C., & Arsenijévic, Y. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00591-x · Cited by 76 · see citing works
Naumann, T., Härtig, W., & Frotscher, M. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00292-2 · Cited by 76 · see citing works
Ho, J. M., Anekonda, V. T., Thompson, B. W., Zhu, M., Curry, R. W., Hwang, B. H., Morton, G. J., Schwartz, M. W., Baskin, D. G., Appleyard, S. M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1148 · Cited by 74 · see citing works
Tobin, V. A., Leng, G., & Ludwig, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00261 · Cited by 70 · see citing works
Calcium-channel subtypes in the somata and axon terminals of magnocellular neurosecretory cells
Fisher, T. E. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10034-5 · Cited by 68 · see citing works
Gutnick, A., Blechman, J., Kaslin, J., Herwig, L., Belting, H., Affolter, M., Bonkowsky, J. L., & Levkowitz, G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.004 · Cited by 67 · see citing works
No vasopressin cell loss in the human hypothalamus in aging and Alzheimer's disease
Woude, P. F. V. D., Goudsmit, E., Wierda, M., Purba, J. S., Hofman, M. A., Bogte, H., & Swaab, D. F. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)80003-a · Cited by 63 · see citing works
Pathways of Cell Infection by Parvoviruses and Adeno-Associated Viruses
Vihinen‐Ranta, M., Suikkanen, S., & Parrish, C. R. (2004) · Journal of Virology · doi:10.1128/jvi.78.13.6709-6714.2004 · Cited by 60 · see citing works
Wircer, E., Blechman, J., Borodovsky, N., Tsoory, M., Nunes, A. R., Oliveira, R. F., & Levkowitz, G. (2017) · eLife · doi:10.7554/elife.22170 · Cited by 60 · see citing works
Juif, P., Breton, J., Rajalu, M., Charlet, A., Goumon, Y., & Poisbeau, P. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3084-12.2013 · Cited by 58 · see citing works
Temporal progression of hypothalamic patterning by a dual action of BMP
Ohyama, K., Das, R. M., & Placzek, M. (2008) · Development · doi:10.1242/dev.027078 · Cited by 55 · see citing works
Kita, I., Yoshida, Y., & Nishino, S. (2006) · Neuroscience Research · doi:10.1016/j.neures.2005.12.005 · Cited by 53 · see citing works
Electrical properties of oxytocin neurons in organotypic cultures from postnatal rat hypothalamus
Jourdain, P., Poulain, D. A., Theodosis, D. T., & Israël, J.-M. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.4.2772 · Cited by 53 · see citing works
Morton, A. (1969) · The Journal of Comparative Neurology · doi:10.1002/cne.901360203 · Cited by 50 · see citing works
Muscatelli, F., Desarménien, M. G., Matarazzo, V. A., & Grinevich, V. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_16 · Cited by 46 · see citing works
Self-citationJiang, Q. B., & Wakerley, J. B. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020806 · Cited by 42 · see citing works
Vasopressin and oxytocin gene expression in the human hypothalamus
Sukhov, R. R., Walker, L. C., Rance, N. E., Price, D. L., & Young, W. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903370210 · Cited by 39 · see citing works
Generation of Oxtr cDNAHA‐Ires‐Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner
Hidema, S., Fukuda, T., Hiraoka, Y., Mizukami, H., Hayashi, R., Otsuka, A., Suzuki, S., Miyazaki, S., & Nishimori, K. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25393 · Cited by 38 · see citing works
Motojima, Y., Kawasaki, M., Matsuura, T., Saito, R., Yoshimura, M., Hashimoto, H., Ueno, H., Maruyama, T., Suzuki, H., Ohnishi, H., et al. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.02.005 · Cited by 36 · see citing works
Maturation of Human Hypothalamic Neurosecretion
Rinne, U. K., Kivalo, E., & Talanti, S. (2009) · Biologia Neonatorum · doi:10.1159/000239845 · Cited by 35 · see citing works
Wrobel, L. J., Reymond, I., Dupré, A., & Raggenbass, M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.001 · Cited by 31 · see citing works
Gilligan, P., Brenner, S., & Venkatesh, B. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01090.x · Cited by 27 · see citing works
Oxytocin Mobilizes Midbrain Dopamine toward Sociality
Charlet, A., & Grinevich, V. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.002 · Cited by 25 · see citing works
Self-citationCondés‐Lara, M., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., Diez-Martínez, D. C., & Rodríguez-Jiménez, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.02.032 · Cited by 23 · see citing works
Electrophysiological Studies of Oxytocin Neurons in Organotypic Slice Cultures
Jourdain, P., Dupouy, B., Bonhomme, R., Theodosis, D. T., Poulain, D. A., & Israël, J.-M. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_16 · Cited by 17 · see citing works
Plasticity of Nonapeptidergic Neurosecretory Cells in Fish Hypothalamus and Neurohypophysis
Garlov, P. E. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)45005-6 · Cited by 15 · see citing works
Bowyer, J. F., Tranter, K. M., Sarkar, S., et al. (2014) · Current Neurovascular Research · doi:10.2174/1567202610666131124235011 · Cited by 9 · see citing works
Grinevich, V., & Polenov, A. L. (1995) · PubMed · Cited by 8 · see citing works
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Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons
Tang, Y., Benusiglio, D., Lefevre, A., Hilfiger, L., Althammer, F., Bludau, A., Hagiwara, D., Baudon, A., Darbon, P., Schimmer, J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0674-y · Cited by 249 · see citing works
Self-citationOxytocin signaling in the lateral septum prevents social fear during lactation
Menon, R., Grund, T., Zoicas, I., Althammer, F., Fiedler, D., Biermeier, V., Bosch, O. J., Hiraoka, Y., Nishimori, K., Eliava, M., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.044 · Cited by 211 · see citing works
Self-citationInterplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors
Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139 · see citing works
Self-citationNeural circuitry for maternal oxytocin release induced by infant cries
Valtcheva, S., Issa, H. A., Bair-Marshall, C. J., Martin, K. A., Jung, K., Zhang, Y., Kwon, H.-B., & Froemke, R. C. (2023) · Nature · doi:10.1038/s41586-023-06540-4 · Cited by 115 · see citing works
Parallel social information processing circuits are differentially impacted in autism
Lewis, E. M., Stein-O’Brien, G. L., Patino, A. V., Nardou, R., Grossman, C. D., Brown, M., Bangamwabo, B., Ndiaye, N., Giovinazzo, D., Dardani, I., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.10.002 · Cited by 72 · see citing works
Thalamic integration of social stimuli regulating parental behavior and the oxytocin system
Dobolyi, A., Cservenák, M., & Young, L. J. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.05.002 · Cited by 64 · see citing works
Neural functions of hypothalamic oxytocin and its regulation
Wang, P., Wang, S. C., Liu, X., Jia, S., Wang, X., Li, T., Yu, J., Parpura, V., & Wang, Y.-F. (2022) · ASN Neuro · doi:10.1177/17590914221100706 · Cited by 59 · see citing works
Neuromodulation of maternal circuits by oxytocin
Valtcheva, S., & Froemke, R. C. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-2883-1 · Cited by 54 · see citing works
Inoue, K., Ford, C. L., Horie, K., & Young, L. J. (2022) · Journal of Comparative Neurology · doi:10.1002/cne.25382 · Cited by 45 · see citing works
Diversity of central oxytocinergic projections
Jirikowski, G. F. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-2960-5 · Cited by 27 · see citing works
- Authors
- Althammer, F., & Grinevich, V.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Grinevich, V.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2018-08
- Volume
- 30
- Issue
- 8
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2760991324
- Cited by
- 138
- References
- 111
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 15 · 2023: 17 · 2022: 19 · 2021: 18 · 2020: 14 · 2019: 15 · 2018: 15
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (GR 3619/701)
- Fritz Thyssen Stiftung
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin neurons, hypothalamus, magnocellular neurons, parvocellular neurons, axonal projections, neuronal connectivity, oxytocinergic system, social-emotional behavior, pain perception, autonomic regulation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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