The Vagus Nerve is One Route of Transneural Invasion for Intranasally Inoculated Influenza A Virus in Mice
Open accessAbstract
Intranasally inoculated neurotropic influenza viruses in mice infect not only the respiratory tract but also the central nervous system (CNS), mainly the brain stem. 26 , 34 Previous studies suggested that the route of invasion of virus into the CNS was via the peripheral nervous system, especially the vagus nerve. To evaluate the transvagal transmission of the virus, we intranasally inoculated unilaterally vagectomized mice with a virulent influenza virus (strain 24a5b) and examined the distribution of the viral protein and genome by immunohistochemistry and in situ hybridization over time. An asymmetric distribution of viral antigens was observed between vagal (nodose) ganglia: viral antigen was detected in the vagal ganglion of the vagectomized side 2 days later than in the vagal ganglion of the intact side. The virus was apparently transported from the respiratory mucosa to the CNS directly and decussately via the vagus nerve and centrifugally to the vagal ganglion of the vagectomized side. The results of this study, thus, demonstrate that neurotropic influenza virus travels to the CNS mainly via the vagus nerve.
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CNS viral invasion can occur through a vagus nerve mediated trans-synaptic route, through intranasal inoculation of the influenza virus.
“CNS viral invasion can occur through vagus nerve mediated trans-synaptic route, through intranasal inoculation of the influenza virus [177].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [177]
Partially vagotomized animals inoculated with the virus showed viral presence in the root ganglia, bilaterally.
“Partially (ipsilaterally) vagotomized animals inoculated with the virus showed viral presence in the root ganglia, bilaterally.”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [177]
Trans-synaptic routes have been reported in different coronaviruses, such as HEV67 and avian bronchitis virus.
“Trans-synaptic routes have been reported in different coronaviruses (CoVs), such as HEV67 [175, 176] and in the avian bronchitis virus [177, 178].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [177]
The virus reached the ganglion contralateral to the de-afferentation first, suggesting a less effective transport after vagus nerve injury.
“The virus reached the ganglion contralateral to the de-afferentation first, suggesting a less effective transport after vagus nerve injury.”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [177]
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- Authors
- Matsuda, K., Park, C. H., Sunden, Y., Kimura, T., Ochiai, K., Kida, H., & Umemura, T.
- Affiliations
- Hokkaido University (JP)
- Corresponding author
- Umemura, T.
- Venue
- Veterinary Pathology
- Publisher
- SAGE Publications
- Published
- 2004-03
- Volume
- 41
- Issue
- 2
- Pages
- 101-107
- ISSN
- 0300-9858 (ISSN-L)
- 1544-2217
- OpenAlex
- W2105165121
- Cited by
- 189
- References
- 42
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 12 · 2022: 18 · 2021: 39 · 2020: 71 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 5
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Veterinary Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- influenza A virus, vagus nerve, central nervous system infection, nodose ganglion, peripheral nervous system, viral dissemination, mouse model
- MeSH terms
- Animals, Brain Stem, Immunohistochemistry, Lung, Nodose Ganglion, Orthomyxoviridae Infections, Influenza A virus, Vagus Nerve, In Situ Hybridization, Respiratory Mucosa, Mice
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